SLC6A12 and LIN7A

Number of citations of the paper that reports this interaction (PMID 10228153)
20

Data Source:
HPRD (in vitro, in vivo)

		SLC6A12	LIN7A
Gene Name		solute carrier family 6 (neurotransmitter transporter), member 12	lin-7 homolog A (C. elegans)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane	Cell-cell Junction Tight Junction Postsynaptic Density Basolateral Plasma Membrane Neuron Projection Synapse Postsynaptic Membrane Extracellular Vesicular Exosome MPP7-DLG1-LIN7 Complex
	Molecular Function	Neurotransmitter:sodium Symporter Activity Gamma-aminobutyric Acid:sodium Symporter Activity	Protein Binding PDZ Domain Binding L27 Domain Binding
	Biological Process	Transport Ion Transport Amino Acid Transport Synaptic Transmission Neurotransmitter Secretion Cellular Water Homeostasis Response To Organic Substance Gamma-aminobutyric Acid Transport Transmembrane Transport Cellular Hyperosmotic Response	Protein Complex Assembly Exocytosis Neurotransmitter Secretion Asymmetric Protein Localization Protein Transport Maintenance Of Epithelial Cell Apical/basal Polarity Synaptic Vesicle Transport Inner Ear Development Protein Localization To Basolateral Plasma Membrane
Pathways		Na+/Cl- dependent neurotransmitter transporters Transport of inorganic cations/anions and amino acids/oligopeptides Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds GABA synthesis, release, reuptake and degradation SLC-mediated transmembrane transport Metabolism of amino acids and derivatives Reuptake of GABA Neurotransmitter Release Cycle Amino acid transport across the plasma membrane Creatine metabolism Transmission across Chemical Synapses
Drugs
Diseases
GWAS		Chronic kidney disease ( 20383146) Metabolite levels ( 23378610)	Dental caries ( 23259602)
Protein-Protein Interactions		3 interactors: ERBB2IP LIN7A REL	19 interactors: ABCA1 APP BAI1 BAIAP2 CASK DLG2 DLG3 DLG4 FAM9B GOLGA2 GRIN2B KCNJ12 MPP2 MPP3 MPP5 MPP6 NOTCH2NL SLC6A12 ZYX
Entrez ID		6539	8825
HPRD ID		04358	04542
Ensembl ID		ENSG00000111181	ENSG00000111052
Uniprot IDs		P48065	O14910
PDB IDs
Enriched GO Terms of Interacting Partners?		Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Asymmetric Protein Localization Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Cell Polarity Basal Protein Localization Protein Localization To Basolateral Plasma Membrane Maintenance Of Epithelial Cell Apical/basal Polarity Maintenance Of Apical/basal Cell Polarity Positive Regulation Of Interleukin-12 Biosynthetic Process Maintenance Of Cell Polarity Regulation Of Interleukin-12 Biosynthetic Process	Nucleotide Phosphorylation Receptor Localization To Synapse Protein Localization To Synapse Axonogenesis Signaling Cell-cell Signaling Cell Communication Nucleotide Metabolic Process Axon Development Cell Morphogenesis Involved In Neuron Differentiation Synaptic Transmission Neuron Projection Morphogenesis Nucleobase-containing Small Molecule Metabolic Process Receptor Clustering Cell Morphogenesis Involved In Differentiation Neuron Projection Development Cell Projection Morphogenesis Membrane Organization Cell Part Morphogenesis Cellular Component Assembly Neuron Development Signal Transduction Organophosphate Metabolic Process Secretion Cell Morphogenesis Cellular Response To Stimulus Neuron Differentiation Neurogenesis Neuromuscular Process Nervous System Development Suckling Behavior Cell Projection Organization Protein Localization To Membrane Dendrite Development Multicellular Organismal Development Small Molecule Metabolic Process Learning Axon Guidance Anatomical Structure Morphogenesis Establishment Or Maintenance Of Apical/basal Cell Polarity Cell Development Regulation Of Synaptic Plasticity Phosphorylation System Development Cell Differentiation Secretion By Cell Ionotropic Glutamate Receptor Signaling Pathway Developmental Process Generation Of Neurons Protein Localization To Myelin Sheath Abaxonal Region
Tagcloud ?			adherens associates cadherin carboxyl changing compartment deleted dimer dimerizes dlg1 guanylate homology insoluble junctions l27 lin7c localizes maguk members mpp7 pdz redistributes requiring stabilizes stabilizing stardust tripartite uncharacterized
Tagcloud (Difference) ?			adherens associates cadherin carboxyl changing compartment deleted dimer dimerizes dlg1 guanylate homology insoluble junctions l27 lin7c localizes maguk members mpp7 pdz redistributes requiring stabilizes stabilizing stardust tripartite uncharacterized
Tagcloud (Intersection) ?