SLC6A12 and LIN7A

Number of citations: 40 (PubMedID 10228153)
Data Source: HPRD (in vivo, in vitro)

		SLC6A12	LIN7A
Name		solute carrier family 6 member 12	lin-7 cell polarity scaffold A
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Basolateral Plasma Membrane Cell Projection Presynapse	Plasma Membrane Cell-cell Junction Bicellular Tight Junction Membrane Basolateral Plasma Membrane Synapse Postsynaptic Membrane Extracellular Exosome Anchoring Junction MPP7-DLG1-LIN7 Complex Presynapse Postsynaptic Density Membrane
	Molecular Function	Gamma-aminobutyric Acid:sodium:chloride Symporter Activity Protein Binding Monocarboxylic Acid Transmembrane Transporter Activity Amino Acid Transmembrane Transporter Activity Symporter Activity Transmembrane Transporter Activity	Protein Binding Protein-macromolecule Adaptor Activity L27 Domain Binding
	Biological Process	Amino Acid Transmembrane Transport Neurotransmitter Transport Amino Acid Transport Monocarboxylic Acid Transport Gamma-aminobutyric Acid Transport Glycine Betaine Transport Sodium Ion Transmembrane Transport Gamma-aminobutyric Acid Reuptake	Exocytosis Neurotransmitter Secretion Regulation Of Synaptic Assembly At Neuromuscular Junction Protein Transport Synaptic Vesicle Transport Inner Ear Development Protein-containing Complex Assembly
Pathways		Amino acid transport across the plasma membrane Creatine metabolism Reuptake of GABA	Dopamine Neurotransmitter Release Cycle Neurexins and neuroligins Assembly and cell surface presentation of NMDA receptors
Drugs		Guvacine	None
GWAS		Chronic kidney disease ( 20383146 ) Diisocyanate-induced asthma ( 25918132 ) Metabolite levels ( 23378610 23823483 ) Serum metabolite levels ( 33031748 )	Age-related cataracts (age at onset) ( 25352737 ) Dental caries ( 23259602 )
Interacting Genes		4 interacting genes: CD79A ERBIN LIN7A REL	25 interacting genes: ABCA1 ADGRB1 APP BAIAP2 CASK CHRD DLG2 DLG3 DLG4 DNAJC5 ECM1 FAM9B GOLGA2 GRIN2B KCNJ12 MDFI MPP2 MPP3 MPP7 NOTCH2NLA PALS1 PALS2 SLC6A12 VANGL2 ZYX
Entrez ID		6539	8825
HPRD ID		04358	04542
Ensembl ID		ENSG00000111181	ENSG00000111052
Uniprot IDs		P48065	O14910
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		IgM B Cell Receptor Complex B Cell Receptor Complex NF-kappaB Complex L27 Domain Binding Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway ErbB-2 Class Receptor Binding Basal Protein Localization MPP7-DLG1-LIN7 Complex Basolateral Plasma Membrane Negative Regulation Of Monocyte Chemotactic Protein-1 Production Negative Regulation Of Cytokine Production Regulation Of Synaptic Assembly At Neuromuscular Junction Hemidesmosome Postsynaptic Specialization Negative Regulation Of Interferon-beta Production Anchoring Junction Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway	Cell-cell Junction Adherens Junction Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Establishment Or Maintenance Of Cell Polarity Positive Regulation Of Excitatory Postsynaptic Potential Protein Localization To Cell Junction Plasma Membrane Regulation Of Synaptic Plasticity Postsynaptic Density Membrane Modulation Of Excitatory Postsynaptic Potential Basolateral Plasma Membrane Postsynaptic Density Protein Localization To Synapse Synaptic Membrane Dendritic Spine Modulation Of Chemical Synaptic Transmission Neuromuscular Junction PDZ Domain Binding Cellular Component Assembly Neuron Projection Protein Tetramerization Ionotropic Glutamate Receptor Signaling Pathway Ionotropic Glutamate Receptor Binding Presynapse Organelle Cell Adhesion Regulation Of Nervous System Process Dendritic Shaft Protein Complex Oligomerization Ligand-gated Ion Channel Signaling Pathway NMDA Selective Glutamate Receptor Signaling Pathway Cell Projection Receptor Localization To Synapse Receptor Clustering Glutamate Receptor Signaling Pathway Positive Regulation Of Synaptic Transmission Regulation Of Synapse Organization GMP Kinase Activity Regulation Of Cell Communication Regulation Of Signaling Regulation Of Neuronal Synaptic Plasticity Chemical Synaptic Transmission Intracellular Protein Localization Trans-synaptic Signaling GDP Metabolic Process Synaptic Signaling Juxtaparanode Region Of Axon Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Acetylcholine Receptor Binding