IL18RAP and IL18

Number of citations of the paper that reports this interaction (PubMedID 9792649)
0

Data Source:
HPRD (in vivo)

		IL18RAP	IL18
Description		interleukin 18 receptor accessory protein	interleukin 18
Image
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane Interleukin-18 Receptor Complex	Extracellular Region Extracellular Space Cytoplasm Cytosol
	Molecular Function	Protein Binding Coreceptor Activity Hydrolase Activity Signaling Receptor Activity Interleukin-18 Receptor Activity NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating	Cytokine Activity Protein Binding Interleukin-18 Receptor Binding Receptor Ligand Activity
	Biological Process	Adaptive Immune Response Immune System Process Inflammatory Response Immune Response Signal Transduction Cell Population Proliferation Interleukin-18-mediated Signaling Pathway Neutrophil Activation Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of NF-kappaB Transcription Factor Activity Cellular Response To Hydrogen Peroxide Cellular Response To Cytokine Stimulus Cellular Response To Interleukin-18	Angiogenesis Inflammatory Response Immune Response Cell Surface Receptor Signaling Pathway Cell-cell Signaling Cell Population Proliferation Positive Regulation Of Gene Expression Positive Regulation Of Macrophage Derived Foam Cell Differentiation Cytokine-mediated Signaling Pathway Natural Killer Cell Activation Regulation Of Cell Adhesion Sleep Positive Regulation Of Chemokine Production Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-13 Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Tissue Remodeling Interleukin-18-mediated Signaling Pathway T-helper 1 Type Immune Response Type 2 Immune Response Positive Regulation Of Activated T Cell Proliferation Neutrophil Activation Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Cholesterol Homeostasis Positive Regulation Of T-helper 2 Cell Differentiation Negative Regulation Of Myoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Inflammatory Response Defense Response To Gram-positive Bacterium Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of NK T Cell Proliferation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Establishment Of Skin Barrier Triglyceride Homeostasis Cellular Response To Lipopolysaccharide Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Neuroinflammatory Response Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of T-helper 1 Cell Cytokine Production
Pathways		Interleukin-18 signaling	Interleukin-1 processing Pyroptosis Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Interleukin-18 signaling Purinergic signaling in leishmaniasis infection CASP4-mediated substrate cleavage CASP5-mediated substrate cleavage
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011) Allergic sensitization ( 23817571) Asthma ( 31959851 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 23042114 26482879) Basophil percentage of white cells ( 32888494) Blood protein levels ( 30072576) Celiac disease ( 20190752 22057235 18311140) Crohn's disease ( 28067908 21102463) Delirium ( 29631748) Extranodal natural killer T-cell lymphoma (nasal type) ( 31879220) Inflammatory bowel disease ( 28067908 23128233) Leprosy ( 25642632) Liver fibrosis in pediatric non-alcoholic fatty acid liver disease ( 28918882) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 27863252) Primary biliary cholangitis ( 26394269) Serum protein levels (sST2) ( 23999434) Systemic lupus erythematosus ( 28714469)	Blood protein levels in cardiovascular risk ( 28369058) Inflammatory biomarkers ( 24182552) Interleukin-18 levels ( 27989323 31584380) Protein quantitative trait loci ( 18464913)
Interacting Genes		4 interacting genes: APP CD48 IL18 TRIM54	9 interacting genes: ADIRF CASK CASP1 CASP3 CASP4 IL18BP IL18R1 IL18RAP IL1RL2
Entrez ID		8807	3606
HPRD ID		05147	02976
Ensembl ID		ENSG00000115607	ENSG00000150782
Uniprot IDs		O95256	Q14116
PDB IDs		3WO4 6KN9 7FCH	1J0S 2VXT 3F62 3WO2 3WO3 3WO4 4EEE 4EKX 4HJJ 4R6U 4XFS 4XFT 4XFU 7AL7 8J6K 8SPB 8SV1 8URV
Enriched GO Terms of Interacting Partners?		Receptor Ligand Activity Amyloid-beta Complex Immune Response Growth Cone Lamellipodium Positive Regulation Of Chemokine Production Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Chemokine Production Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Defense Response Positive Regulation Of Type II Interferon Production Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Leukocyte Activation Natural Killer Cell Activation Interleukin-18 Receptor Binding Acetylcholine Receptor Activator Activity PTB Domain Binding Innate Immune Response Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Defense Response To Symbiont Defense Response To Other Organism Regulation Of Type II Interferon Production Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Defense Response To Gram-positive Bacterium Lipoprotein Particle Myeloid Leukocyte Activation Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Cell Activation Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Immune System Process Positive Regulation Of Inflammatory Response Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Membrane Raft Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Regulation Of Spontaneous Synaptic Transmission	Interleukin-18-mediated Signaling Pathway Cytokine-mediated Signaling Pathway NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating Inflammatory Response Interleukin-18 Receptor Complex Interleukin-18 Receptor Activity Interleukin-18 Binding Pyroptotic Inflammatory Response NLRP1 Inflammasome Complex Interleukin-1 Receptor Activity Cysteine-type Endopeptidase Activity Immune System Process Cellular Response To Chemical Stress Defense Response Response To Hydrogen Peroxide Canonical Inflammasome Complex Regulation Of Defense Response CARD Domain Binding Pyroptotic Cell Death Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Cysteine-type Peptidase Activity Protein Poly-ADP-ribosylation Regulation Of Inflammatory Response Hydrolase Activity Protein Autoprocessing Positive Regulation Of Defense Response Response To Reactive Oxygen Species Positive Regulation Of Inflammatory Response Interleukin-1-mediated Signaling Pathway Protein Processing Response To Cytokine Response To Peptide Cell Surface Receptor Signaling Pathway Immune Response Response To Stress Response To External Biotic Stimulus Cellular Response To Osmotic Stress Signaling Receptor Activity Adaptive Immune Response Response To Lipopolysaccharide Protein Maturation Positive Regulation Of Cytokine-mediated Signaling Pathway Regulation Of Cytokine Production Response To Molecule Of Bacterial Origin Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Response To Cytokine Stimulus Positive Regulation Of Neuron Apoptotic Process Non-canonical Inflammasome Complex Cellular Response To Interleukin-18 Cellular Response To Hydrogen Peroxide
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