ATP1B1 and NDRG2

Number of citations: 53 (PubMedID 21771789)
Data Source: BioGRID (two hybrid, affinity chromatography technology)

		ATP1B1	NDRG2
Name		ATPase Na+/K+ transporting subunit beta 1	NDRG family member 2
Structure
GO Annotations	Cellular Component	Plasma Membrane Sodium:potassium-exchanging ATPase Complex Caveola Intercalated Disc Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane T-tubule Organelle Membrane Sperm Flagellum Sarcolemma Extracellular Exosome Extracellular Vesicle	Nucleus Cytoplasm Golgi Apparatus Cytosol Growth Cone Cell Projection Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	ATPase Activator Activity P-type Sodium:potassium-exchanging Transporter Activity Protein Binding Protein Kinase Binding MHC Class II Protein Complex Binding Protein-macromolecule Adaptor Activity Protein Heterodimerization Activity ATPase Binding Transporter Activator Activity	Protein Binding
	Biological Process	Response To Hypoxia Immune System Process Monoatomic Ion Transport Potassium Ion Transport Sodium Ion Transport Intracellular Calcium Ion Homeostasis Intracellular Sodium Ion Homeostasis Cell Adhesion Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Regulation Of Gene Expression Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Metal Ion Transport Intracellular Potassium Ion Homeostasis Sodium Ion Transmembrane Transport Sodium Ion Export Across Plasma Membrane Protein Transport Into Plasma Membrane Raft Innate Immune Response ATP Metabolic Process Protein Stabilization Relaxation Of Cardiac Muscle Cardiac Muscle Contraction Protein Localization To Plasma Membrane Membrane Repolarization Membrane Repolarization During Cardiac Muscle Cell Action Potential Cell Communication By Electrical Coupling Involved In Cardiac Conduction Proton Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transport Positive Regulation Of Sodium Ion Export Across Plasma Membrane Positive Regulation Of Potassium Ion Import Across Plasma Membrane Potassium Ion Import Across Plasma Membrane	Negative Regulation Of Cytokine Production Signal Transduction Nervous System Development Regulation Of Vascular Endothelial Growth Factor Production Wnt Signaling Pathway Substantia Nigra Development Cell Differentiation Negative Regulation Of ERK1 And ERK2 Cascade Regulation Of Platelet-derived Growth Factor Production Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Vascular Associated Smooth Muscle Cell Proliferation
Pathways		Basigin interactions Ion homeostasis Ion transport by P-type ATPases Potential therapeutics for SARS	None
Drugs		Bisacodyl Tegoprazan	None
GWAS		Coronary artery disease ( 29212778 33020668 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Electrocardiographic traits ( 25055868 ) Electrocardiographic traits (multivariate) ( 32602732 ) Fuchs's corneal dystrophy ( 28358029 ) Haemorrhoidal disease ( 33888516 ) Keratoconus ( 33649486 ) Mitochondrial DNA levels ( 25240745 ) QT interval ( 19305409 23166209 24952745 29213071 29874175 ) Rosacea symptom severity ( 29771307 )	Heart rate response to exercise ( 29769521 ) Hip circumference adjusted for BMI ( 28552196 ) Resting heart rate ( 27798624 )
Novel Interactors		7 novel interactors: CD84 CREG1 HCRTR1 PRRX1 SERPINC1 THOC1 TM4SF1	None recorded
Interacting Genes		23 interacting genes: AGTR1 BACE1 BARD1 BRCA1 CRIP2 DDAH2 EGFR EZH2 FXYD1 FXYD7 GCH1 HTR2B KMT2B LRIF1 NDRG2 OGT PAXIP1 PSME1 TMEM132D TRIM14 TRMT2A TSC22D2 USP4	8 interacting genes: AGTR1 ATP1B1 CCR4 CLN8 CTDP1 MOB2 RABAC1 TRIM32
Entrez ID		481	57447
HPRD ID		01663	17630
Ensembl ID		ENSG00000143153	ENSG00000165795
Uniprot IDs		A3KLL5 P05026	Q9UN36
PDB IDs		7E1Z 7E20 7E21 8D3U 8D3V 8D3W 8D3X 8D3Y 8ZYJ	2XMQ 2XMR 2XMS
GO Terms Enriched among Interactors		Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex BRCA1-B Complex Nuclear Ubiquitin Ligase Complex BRCA1-C Complex BRCA1-A Complex Ubiquitin-modified Histone Reader Activity Positive Regulation Of Sodium Ion Export Across Plasma Membrane Ion Channel Regulator Activity Regulation Of Metabolic Process Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition DNA Strand Resection Involved In Replication Fork Processing Regulation Of Primary Metabolic Process Positive Regulation Of Sodium Ion Transmembrane Transport Chromatin Organization Angiotensin Type I Receptor Activity Protein K6-linked Ubiquitination Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of Metabolic Process Regulation Of DNA Damage Checkpoint Chromatin Remodeling Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of MRNA 3'-end Processing Regulation Of Protein Metabolic Process Sex-chromosome Dosage Compensation Dosage Compensation By Inactivation Of X Chromosome Regulation Of ERK1 And ERK2 Cascade Regulation Of Protein Modification Process Multivesicular Body, Internal Vesicle Lumen Hepatocyte Homeostasis Cardiac Muscle Hypertrophy Muscle Hypertrophy GTP Cyclohydrolase I Activity Negative Regulation Of Protein Glutathionylation Sodium Channel Regulator Activity Positive Regulation Of Sodium Ion Transport Adenosine Receptor Binding Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Negative Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Histone Methyltransferase Complex Nuclear Matrix Golgi-associated Vesicle Lumen C-methyltransferase Activity Regulation Of Reactive Oxygen Species Metabolic Process	Tat Protein Binding Calcium-mediated Signaling Regulation Of Cell Growth Angiotensin Type I Receptor Activity Bradykinin Receptor Binding Protein Transport Into Plasma Membrane Raft Somatic Motor Neuron Differentiation Glutamate Reuptake Retinal Rod Cell Apoptotic Process Regulation Of Striated Muscle Cell Differentiation TFIIF-class Transcription Factor Complex Binding Protein Localization To Phagocytic Vesicle Positive Regulation Of Interleukin-17-mediated Signaling Pathway Actin Ubiquitination Positive Regulation Of Chemokine (C-C Motif) Ligand 20 Production Positive Regulation Of Cytosolic Calcium Ion Concentration Defense Response Regulation Of Growth Angiotensin Type II Receptor Activity Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Regulation Of System Process Phospholipase C-activating Angiotensin-activated Signaling Pathway Renin-angiotensin Regulation Of Aldosterone Production Import Across Plasma Membrane Positive Regulation Of Potassium Ion Import Across Plasma Membrane Protein Localization To Plasma Membrane Raft Protein Transport Into Membrane Raft Homeostatic Process Regulation Of Muscle Cell Differentiation Actin Modification Striated Muscle Myosin Thick Filament