ATP1B1 and HCRTR1

		ATP1B1	HCRTR1
Description		ATPase Na+/K+ transporting subunit beta 1	hypocretin receptor 1
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GO Annotations	Cellular Component	Plasma Membrane Sodium:potassium-exchanging ATPase Complex Caveola Intercalated Disc Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane T-tubule Organelle Membrane Sperm Flagellum Sarcolemma Extracellular Exosome Extracellular Vesicle	Plasma Membrane Membrane Synapse
	Molecular Function	ATPase Activator Activity P-type Sodium:potassium-exchanging Transporter Activity Protein Binding Protein Kinase Binding MHC Class II Protein Complex Binding Protein-macromolecule Adaptor Activity Protein Heterodimerization Activity ATPase Binding Transporter Activator Activity	G Protein-coupled Receptor Activity Protein Binding Orexin Receptor Activity Peptide Hormone Binding
	Biological Process	Response To Hypoxia Immune System Process Monoatomic Ion Transport Potassium Ion Transport Sodium Ion Transport Intracellular Calcium Ion Homeostasis Intracellular Sodium Ion Homeostasis Cell Adhesion Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Regulation Of Gene Expression Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Metal Ion Transport Intracellular Potassium Ion Homeostasis Sodium Ion Transmembrane Transport Sodium Ion Export Across Plasma Membrane Protein Transport Into Plasma Membrane Raft Innate Immune Response ATP Metabolic Process Protein Stabilization Relaxation Of Cardiac Muscle Cardiac Muscle Contraction Protein Localization To Plasma Membrane Membrane Repolarization Membrane Repolarization During Cardiac Muscle Cell Action Potential Cell Communication By Electrical Coupling Involved In Cardiac Conduction Proton Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transport Positive Regulation Of Sodium Ion Export Across Plasma Membrane Positive Regulation Of Potassium Ion Import Across Plasma Membrane Potassium Ion Import Across Plasma Membrane	Signal Transduction G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Chemical Synaptic Transmission Feeding Behavior Cellular Response To Hormone Stimulus Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of ERK1 And ERK2 Cascade
Pathways		Basigin interactions Ion homeostasis Ion transport by P-type ATPases Potential therapeutics for SARS	Orexin and neuropeptides FF and QRFP bind to their respective receptors G alpha (q) signalling events
Drugs		Bisacodyl Tegoprazan	Suvorexant Lemborexant Daridorexant
Diseases
GWAS		Coronary artery disease ( 29212778 33020668) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits ( 25055868) Electrocardiographic traits (multivariate) ( 32602732) Fuchs's corneal dystrophy ( 28358029) Haemorrhoidal disease ( 33888516) Keratoconus ( 33649486) Mitochondrial DNA levels ( 25240745) QT interval ( 19305409 23166209 24952745 29213071 29874175) Rosacea symptom severity ( 29771307)	Adiponectin levels ( 33562295) Asthma ( 31959851) Body mass index ( 26426971) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Daytime nap ( 33568662) General cognitive ability ( 29844566) Hypoalbuminemia ( 34050200)
Interacting Genes		23 interacting genes: AGTR1 BACE1 BARD1 BRCA1 CRIP2 DDAH2 EGFR EZH2 FXYD1 FXYD7 GCH1 HTR2B KMT2B LRIF1 NDRG2 OGT PAXIP1 PSME1 TMEM132D TRIM14 TRMT2A TSC22D2 USP4	4 interacting genes: ARRB1 ARRB2 CNR1 HCRT
Entrez ID		481	3061
HPRD ID		01663	03863
Ensembl ID		ENSG00000143153	ENSG00000121764
Uniprot IDs		A3KLL5 P05026	A6NMV7 O43613
PDB IDs		7E1Z 7E20 7E21 8D3U 8D3V 8D3W 8D3X 8D3Y 8ZYJ	4ZJ8 4ZJC 6TO7 6TOD 6TOS 6TOT 6TP3 6TP4 6TP6 6TQ4 6TQ6 6TQ7 6TQ9 6V9S
Enriched GO Terms of Interacting Partners?		Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex BRCA1-B Complex Nuclear Ubiquitin Ligase Complex BRCA1-C Complex BRCA1-A Complex Ubiquitin-modified Histone Reader Activity Positive Regulation Of Sodium Ion Export Across Plasma Membrane Ion Channel Regulator Activity Regulation Of Metabolic Process Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition DNA Strand Resection Involved In Replication Fork Processing Regulation Of Primary Metabolic Process Positive Regulation Of Sodium Ion Transmembrane Transport Chromatin Organization Angiotensin Type I Receptor Activity Protein K6-linked Ubiquitination Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of Metabolic Process Regulation Of DNA Damage Checkpoint Chromatin Remodeling Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of MRNA 3'-end Processing Regulation Of Protein Metabolic Process Sex-chromosome Dosage Compensation Dosage Compensation By Inactivation Of X Chromosome Regulation Of ERK1 And ERK2 Cascade Regulation Of Protein Modification Process Multivesicular Body, Internal Vesicle Lumen Hepatocyte Homeostasis Cardiac Muscle Hypertrophy Muscle Hypertrophy GTP Cyclohydrolase I Activity Negative Regulation Of Protein Glutathionylation Sodium Channel Regulator Activity Positive Regulation Of Sodium Ion Transport Adenosine Receptor Binding Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Negative Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Histone Methyltransferase Complex Nuclear Matrix Golgi-associated Vesicle Lumen C-methyltransferase Activity Regulation Of Reactive Oxygen Species Metabolic Process	Angiotensin Receptor Binding Negative Adaptation Of Signaling Pathway Desensitization Of G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Internalization Regulation Of System Process Positive Regulation Of Receptor Internalization Positive Regulation Of Cardiac Muscle Hypertrophy Regulation Of Muscle System Process Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Interleukin-6 Production Positive Regulation Of Transport Cytoplasmic Vesicle Positive Regulation Of Receptor-mediated Endocytosis Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Endocytic Vesicle Membrane Receptor Internalization Regulation Of Receptor Internalization G Protein-coupled Receptor Binding Negative Regulation Of DNA-binding Transcription Factor Activity Clathrin-coated Pit Negative Regulation Of Protein Ubiquitination Regulation Of Cardiac Muscle Hypertrophy Excitatory Postsynaptic Potential Type 1 Orexin Receptor Binding Type 2 Orexin Receptor Binding Regulation Of Membrane Potential Regulation Of Potassium Ion Transport Negative Regulation Of Post-translational Protein Modification Regulation Of Postsynaptic Membrane Potential Protein Transport Into Plasma Membrane Raft Cannabinoid Receptor Activity Type II Interferon Receptor Activity Poly(C) RNA Binding Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Synaptic Transmission, Dopaminergic Cannabinoid Signaling Pathway Retrograde Trans-synaptic Signaling By Endocannabinoid Signal Transduction Import Into Cell Regulation Of Interleukin-6 Production Regulation Of G Protein-coupled Receptor Signaling Pathway Protein Transport Into Membrane Raft Positive Regulation Of Endocytosis Regulation Of Transport Cytoplasmic Vesicle Membrane Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Positive Regulation Of Potassium Ion Import Across Plasma Membrane Cell Communication Protein Localization To Plasma Membrane Raft Neuronal Dense Core Vesicle Lumen
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