GPR143

Description		G protein-coupled receptor 143
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Lysosome Lysosomal Membrane Golgi Apparatus Plasma Membrane Membrane Apical Plasma Membrane Nuclear Body Cell Junction Melanosome Membrane Melanosome
	Molecular Function	G Protein-coupled Receptor Activity Protein Binding Dopamine Binding L-DOPA Receptor Activity L-DOPA Binding L-tyrosine Binding
	Biological Process	Eye Pigment Biosynthetic Process Signal Transduction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Visual Perception Melanosome Localization Melanosome Transport Melanosome Organization Regulation Of Melanosome Transport Regulation Of Melanosome Organization
Pathways		Amine ligand-binding receptors G alpha (q) signalling events Regulation of MITF-M-dependent genes involved in pigmentation
Drugs
Diseases		Ocular albinism; Ocular albinism, type I (OA1); Waardenburg syndrome, type II (WS2-OA) Congenital motor nystagmus (CMN); Idiopathic congenital nystagmus (ICN)
GWAS		Prostate cancer ( 23535732)
Interacting Genes		2 interacting genes: GNAI1 SUCLG2
Entrez ID		4935
HPRD ID		02355
Ensembl ID		ENSG00000101850
Uniprot IDs		P51810
PDB IDs
Enriched GO Terms of Interacting Partners?		GDP Binding D2 Dopamine Receptor Binding Magnesium Ion Binding Adenylate Cyclase Inhibitor Activity Positive Regulation Of Relaxation Of Smooth Muscle GTP Binding Adenylate Cyclase Regulator Activity G Protein-coupled Serotonin Receptor Binding Succinate-CoA Ligase (ADP-forming) Activity Succinate-CoA Ligase Complex Succinate-CoA Ligase Complex (GDP-forming) Succinate-CoA Ligase (GDP-forming) Activity Succinyl-CoA Catabolic Process Positive Regulation Of Protein Localization To Cell Cortex Succinate Metabolic Process Regulation Of Protein Localization To Cell Cortex Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Succinyl-CoA Metabolic Process Cellular Response To Forskolin Guanyl Nucleotide Binding Response To Forskolin Regulation Of Relaxation Of Muscle Positive Regulation Of Cholesterol Biosynthetic Process G-protein Beta/gamma-subunit Complex Binding G Protein-coupled Serotonin Receptor Signaling Pathway Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Steroid Biosynthetic Process Response To Prostaglandin E Positive Regulation Of Cholesterol Metabolic Process T Cell Migration Heterotrimeric G-protein Complex Tricarboxylic Acid Cycle Negative Regulation Of Insulin Secretion Regulation Of Mitotic Spindle Organization Positive Regulation Of Steroid Metabolic Process Negative Regulation Of Peptide Secretion Regulation Of Cholesterol Metabolic Process Lymphocyte Migration Negative Regulation Of Hormone Secretion G Protein Activity G Protein-coupled Receptor Binding Negative Regulation Of Protein Secretion Positive Regulation Of Protein Localization To Cell Periphery Chemokine-mediated Signaling Pathway Regulation Of Steroid Biosynthetic Process Nucleotide Binding Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Acyl-CoA Metabolic Process Dicarboxylic Acid Metabolic Process Neuropeptide Signaling Pathway
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