TNFRSF18 and KCNAB2

		TNFRSF18	KCNAB2
Description		TNF receptor superfamily member 18	potassium voltage-gated channel subfamily A regulatory beta subunit 2
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GO Annotations	Cellular Component	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Membrane	Cytoplasm Cytosol Cytoskeleton Microtubule Plasma Membrane Voltage-gated Potassium Channel Complex Cytoplasmic Side Of Plasma Membrane Membrane Axon Specific Granule Membrane Cell Projection Neuron Projection Juxtaparanode Region Of Axon Synapse Tertiary Granule Membrane Pinceau Fiber
	Molecular Function	Tumor Necrosis Factor Receptor Activity Protein Binding	Voltage-gated Potassium Channel Activity Protein Binding Alcohol Dehydrogenase (NADP+) Activity Potassium Channel Regulator Activity Oxidoreductase Activity Transmembrane Transporter Binding Methylglyoxal Reductase (NADPH) (acetol Producing) Activity
	Biological Process	Positive Regulation Of Leukocyte Migration Apoptotic Process Signal Transduction Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Apoptotic Process Positive Regulation Of Cell Adhesion	Monoatomic Ion Transport Potassium Ion Transport Potassium Ion Transmembrane Transport Regulation Of Potassium Ion Transmembrane Transport Regulation Of Protein Localization To Cell Surface
Pathways		TNFs bind their physiological receptors RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	Voltage gated Potassium channels Neutrophil degranulation
Drugs			Enflurane Promethazine Miconazole
Diseases
GWAS		Inflammatory bowel disease ( 23128233)	Metabolite levels ( 23823483)
Interacting Genes		6 interacting genes: LNX1 TNFSF18 TRAF1 TRAF2 TRAF3 UBQLN2	10 interacting genes: ATXN1 CD4 CEBPA KCNA2 LCOR NEDD4 NEDD4L SLC39A1 SLC39A2 SQSTM1
Entrez ID		8784	8514
HPRD ID		04879	03090
Ensembl ID		ENSG00000186891	ENSG00000069424
Uniprot IDs		A0A0R7FDM1 Q9Y5U5	B2R776 Q13303
PDB IDs		7KHD 7LAW	1ZSX 7EJ1 7EJ2 7WF3 7WF4
Enriched GO Terms of Interacting Partners?		Tumor Necrosis Factor Receptor Binding Thioesterase Binding Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of DNA-binding Transcription Factor Activity Tumor Necrosis Factor Receptor Superfamily Binding Signaling Adaptor Activity CD40 Receptor Complex Ubiquitin-protein Transferase Activity Alcohol Dehydrogenase (NADP+) Activity Cytoplasmic Side Of Plasma Membrane Regulation Of Canonical NF-kappaB Signal Transduction Identical Protein Binding Ubiquitin Protein Ligase Activity Cytoplasm Cytokine-mediated Signaling Pathway Lymphocyte Activation Polyubiquitin Modification-dependent Protein Binding Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Positive Regulation Of Immune System Process Regulation Of B Cell Cytokine Production Monocyte Proliferation Positive Regulation Of Interleukin-17A Production Toll-like Receptor Signaling Pathway Leukocyte Activation Regulation Of Adaptive Immune Response Steroid Dehydrogenase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor 3-alpha-hydroxysteroid 3-dehydrogenase [NAD(P)+] Activity TORC2 Complex Disassembly Pinceau Fiber MWP Complex Positive Regulation Of Type I Hypersensitivity Cell Activation B Cell Affinity Maturation 17-alpha,20-alpha-dihydroxypregn-4-en-3-one Dehydrogenase [NAD(P)+] Activity 3-beta-hydroxy-5-beta-steroid Dehydrogenase (NADP+) Activity Trans-1,2-dihydrobenzene-1,2-diol Dehydrogenase Activity Ubiquitin Protein Ligase Binding TRAF2-GSTP1 Complex TORC1 Complex Assembly CD40 Receptor Binding Methylglyoxal Reductase (NADPH) (acetol Producing) Activity Negative Regulation Of G Protein-coupled Receptor Internalization Regulation Of Immunoglobulin Production Zinc Ion Binding PDZ Domain Binding Eosinophil Homeostasis Positive Regulation Of Type III Hypersensitivity Positive Regulation Of Type I Interferon Production	Fat Cell Proliferation Sodium Channel Inhibitor Activity Negative Regulation Of Potassium Ion Export Across Plasma Membrane Potassium Channel Inhibitor Activity Metal Ion Transport Regulation Of Potassium Ion Export Across Plasma Membrane Negative Regulation Of Sodium Ion Transport Monoatomic Cation Transport Receptor Catabolic Process Negative Regulation Of Potassium Ion Transmembrane Transport Metal Ion Transmembrane Transporter Activity Zinc Ion Transmembrane Transporter Activity Positive Regulation Of Protein Metabolic Process DNA-templated Transcription Zinc Ion Transport Zinc Ion Transmembrane Transport Regulation Of Membrane Potential Ionotropic Glutamate Receptor Binding Negative Regulation Of Potassium Ion Transport Monoatomic Ion Transport Regulation Of Protein Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Neuromuscular Junction Development Positive Regulation Of Protein Catabolic Process Macrophage Differentiation Positive Regulation Of Catabolic Process Receptor Metabolic Process Interleukin-16 Binding Regulation Of Biological Quality Interleukin-16 Receptor Activity Helper T Cell Enhancement Of Adaptive Immune Response Regulation Of Monoatomic Cation Transmembrane Transport RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Protein Targeting To Vacuole Protein Monoubiquitination Formation Of Structure Involved In A Symbiotic Process Protein Polyubiquitination Regulation Of Dendrite Morphogenesis Establishment Of Protein Localization To Vacuole Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Potassium Ion Transmembrane Transport Transcription By RNA Polymerase II Inorganic Ion Transmembrane Transport Energy Homeostasis Negative Regulation Of Cation Transmembrane Transport Regulation Of Sodium Ion Transport Receptor Internalization Response To Methamphetamine Hydrochloride
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