TNFRSF18 and AKR1C1

Data Source: HiPPIP (Novel)

		TNFRSF18	AKR1C1
Name		TNF receptor superfamily member 18	aldo-keto reductase family 1 member C1
Structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Membrane	Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Tumor Necrosis Factor Receptor Activity Protein Binding	Aldose Reductase (NADPH) Activity Estradiol 17-beta-dehydrogenase [NAD(P)+] Activity Protein Binding Alcohol Dehydrogenase (NADP+) Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On NAD(P)H, Quinone Or Similar Compound As Acceptor Carboxylic Acid Binding Bile Acid Binding 3-beta-hydroxy-5-beta-steroid Dehydrogenase (NADP+) Activity Steroid Dehydrogenase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor 17-alpha,20-alpha-dihydroxypregn-4-en-3-one Dehydrogenase [NAD(P)+] Activity Androsterone Dehydrogenase [NAD(P)+] Activity 5-alpha-androstane-3-beta,17-beta-diol Dehydrogenase (NADP+) Activity Androstan-3-alpha,17-beta-diol Dehydrogenase (NAD+) Activity Testosterone Dehydrogenase (NADP+) Activity Ketosteroid Monooxygenase Activity Trans-1,2-dihydrobenzene-1,2-diol Dehydrogenase Activity Indanol Dehydrogenase Activity 3-alpha-hydroxysteroid 3-dehydrogenase [NAD(P)+] Activity
	Biological Process	Positive Regulation Of Leukocyte Migration Apoptotic Process Signal Transduction Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Apoptotic Process Positive Regulation Of Cell Adhesion	Retinoid Metabolic Process Alcohol Metabolic Process Lipid Metabolic Process Prostaglandin Metabolic Process Xenobiotic Metabolic Process Digestion Steroid Metabolic Process Bile Acid Metabolic Process Bile Acid And Bile Salt Transport Intestinal Cholesterol Absorption Epithelial Cell Differentiation Monocarboxylic Acid Metabolic Process Hormone Metabolic Process Progesterone Metabolic Process Retinal Metabolic Process Cholesterol Homeostasis Daunorubicin Metabolic Process Doxorubicin Metabolic Process Cellular Response To Jasmonic Acid Stimulus Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		TNFs bind their physiological receptors RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Synthesis of bile acids and bile salts via 24-hydroxycholesterol Synthesis of bile acids and bile salts via 27-hydroxycholesterol Retinoid metabolism and transport Prednisone ADME
Drugs		None	NADH Salicylic acid Acetylsalicylic acid Nicotinamide adenine dinucleotide phosphate Naringenin 2-HYDROXY-3,5-DIIODOBENZOIC ACID Epitestosterone Hexestrol
GWAS		Inflammatory bowel disease ( 23128233 )	Economic and political preferences (immigration/crime) ( 22566634 ) Height ( 25282103 ) Hip index ( 34021172 ) Hypopharyngeal or laryngeal cancer ( 32276964 ) Lung cancer ( 28604730 ) Metabolite levels ( 23823483 ) Squamous cell lung carcinoma ( 28604730 ) Waist circumference adjusted for body mass index ( 34021172 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )
Novel Interactors		7 novel interactors: AKR1C1 ARHGEF16 BTK DZIP3 KCNAB2 LGALS8 WRAP73	2 novel interactors: SUFU TNFRSF18
Interacting Genes		6 interacting genes: LNX1 TNFSF18 TRAF1 TRAF2 TRAF3 UBQLN2	3 interacting genes: COMMD8 MAPK3 PTPN3
Entrez ID		8784	1645
HPRD ID		04879	07194
Ensembl ID		ENSG00000186891	ENSG00000187134
Uniprot IDs		A0A0R7FDM1 Q9Y5U5	Q04828
PDB IDs		7KHD 7LAW	1MRQ 3C3U 3GUG 3NTY 4YVP 6A7A 6IJX 8JP2
GO Terms Enriched among Interactors		Tumor Necrosis Factor Receptor Binding Thioesterase Binding Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of DNA-binding Transcription Factor Activity Tumor Necrosis Factor Receptor Superfamily Binding Signaling Adaptor Activity CD40 Receptor Complex Ubiquitin-protein Transferase Activity Alcohol Dehydrogenase (NADP+) Activity Cytoplasmic Side Of Plasma Membrane Regulation Of Canonical NF-kappaB Signal Transduction Identical Protein Binding Ubiquitin Protein Ligase Activity Cytoplasm Cytokine-mediated Signaling Pathway Lymphocyte Activation Polyubiquitin Modification-dependent Protein Binding Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Positive Regulation Of Immune System Process Regulation Of B Cell Cytokine Production Monocyte Proliferation Positive Regulation Of Interleukin-17A Production Toll-like Receptor Signaling Pathway Leukocyte Activation Regulation Of Adaptive Immune Response Steroid Dehydrogenase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor 3-alpha-hydroxysteroid 3-dehydrogenase [NAD(P)+] Activity TORC2 Complex Disassembly Pinceau Fiber MWP Complex Positive Regulation Of Type I Hypersensitivity Cell Activation B Cell Affinity Maturation 17-alpha,20-alpha-dihydroxypregn-4-en-3-one Dehydrogenase [NAD(P)+] Activity 3-beta-hydroxy-5-beta-steroid Dehydrogenase (NADP+) Activity Trans-1,2-dihydrobenzene-1,2-diol Dehydrogenase Activity Ubiquitin Protein Ligase Binding TRAF2-GSTP1 Complex TORC1 Complex Assembly CD40 Receptor Binding Methylglyoxal Reductase (NADPH) (acetol Producing) Activity Negative Regulation Of G Protein-coupled Receptor Internalization Regulation Of Immunoglobulin Production Zinc Ion Binding PDZ Domain Binding Eosinophil Homeostasis Positive Regulation Of Type III Hypersensitivity Positive Regulation Of Type I Interferon Production	Negative Regulation Of Proteolysis Phosphotyrosine Residue Binding Regulation Of Proteolysis Negative Regulation Of Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Protein Metabolic Process Regulation Of Cellular Response To Drug Positive Regulation Of Cellular Response To Drug Negative Regulation Of Protein Metabolic Process Negative Regulation Of Protein Catabolic Process Smoothened Signaling Pathway Involved In Spinal Cord Motor Neuron Cell Fate Specification Positive Regulation Of Response To Drug Interleukin-34-mediated Signaling Pathway Positive Regulation Of Leukocyte Migration Smoothened Signaling Pathway Involved In Ventral Spinal Cord Interneuron Specification Signal Transduction Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Golgi Inheritance GLI-SUFU Complex Positive Regulation Of Xenophagy Regulation Of Leukocyte Migration Cardiac Neural Crest Cell Development Involved In Heart Development Caveolin-mediated Endocytosis MAPK Cascade Xenophagy Positive Regulation Of Macrophage Proliferation Trachea Formation Regulation Of Intracellular Transport Negative Regulation Of Membrane Protein Ectodomain Proteolysis Regulation Of Membrane Depolarization During Action Potential Regulation Of Response To Drug Spinal Cord Dorsal/ventral Patterning Outer Ear Morphogenesis Peptidyl-tyrosine Autophosphorylation ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Bergmann Glial Cell Differentiation Tumor Necrosis Factor Receptor Activity Negative Regulation Of T Cell Mediated Immune Response To Tumor Cell Negative Regulation Of Cholesterol Efflux Negative Regulation Of Immune Response To Tumor Cell Cytokine-mediated Signaling Pathway Negative Regulation Of Cholesterol Transport Positive Regulation Of Neuroinflammatory Response Regulation Of Golgi Organization Regulation Of T Cell Mediated Immune Response To Tumor Cell MAP Kinase Activity Negative Regulation Of Signaling Negative Regulation Of Signal Transduction