TNFRSF6B and TNFSF15

Number of citations of the paper that reports this interaction (PubMedID 11911831)
0

Data Source:
HPRD (in vivo)

		TNFRSF6B	TNFSF15
Description		TNF receptor superfamily member 6b	TNF superfamily member 15
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Region Extracellular Space Plasma Membrane Membrane
	Molecular Function	Protein Binding Signaling Receptor Activity	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding
	Biological Process	Apoptotic Process Negative Regulation Of Apoptotic Process	Immune Response Cell Communication Signal Transduction Cell Surface Receptor Signaling Pathway Activation Of NF-kappaB-inducing Kinase Activity Signaling Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		TNFs bind their physiological receptors	TNFs bind their physiological receptors
Drugs
Diseases		Autoimmune lymphoproliferative syndromes (ALPS), including the following five diseases: CD95 (Fas) defect, ALPS type 1a; CD95L (Fas ligand) defect, ALPS type 1b; Caspase 10 defect, ALPS type 2a; Caspase 8 defext, ALPS type 2b; Activaing N-Ras defect, N-Ras ALPS	Crohn's disease
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31361310 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 26482879 25574825 23727859) Blood protein levels ( 30072576) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Glioma ( 22886559) Inflammatory bowel disease ( 28067908 23128233 18758464) Pediatric autoimmune diseases ( 26301688) Prostate cancer ( 23535732) Refractive error ( 32231278) Ulcerative colitis ( 28067908 21297633)	Asthma ( 32296059) Asthma (childhood onset) ( 34022066) Behcet's disease ( 33393726) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 18587394 21102463 32581322 30500874 23266558 26891255) Inflammatory bowel disease ( 18758464 27569725 23128233) Leprosy ( 25642632 20018961) Metabolite levels ( 23823483) Pediatric autoimmune diseases ( 26301688) Primary biliary cholangitis ( 28062665 28425483 23000144 30643196) Ulcerative colitis ( 21297633 20848476) Ulcerative colitis or Crohn's disease ( 21699788)
Interacting Genes		6 interacting genes: FASLG KRTAP10-3 KRTAP10-9 PPP1R7 TNFSF14 TNFSF15	2 interacting genes: TNFRSF25 TNFRSF6B
Entrez ID		8771	9966
HPRD ID		04527	04956
Ensembl ID		ENSG00000243509	ENSG00000181634
Uniprot IDs		O95407	A0A0U5JA19 O95150
PDB IDs		3K51 3MHD 3MI8 4J6G 4KGG 4KGQ 4MSV 5L36	2O0O 2QE3 2RE9 2RJK 2RJL 3K51 3MI8
Enriched GO Terms of Interacting Partners?		Tumor Necrosis Factor Receptor Binding Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Cytokine Activity Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Signaling Receptor Binding Regulation Of Apoptotic Signaling Pathway Keratin Filament Positive Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Process Positive Regulation Of Phosphatidylserine Exposure On Apoptotic Cell Surface Signaling Cell Communication Retinal Cell Programmed Cell Death Intermediate Filament Cytoplasmic Vesicle Lumen Positive Regulation Of Phospholipid Translocation Inflammatory Cell Apoptotic Process Necroptotic Signaling Pathway Intracellular Chloride Ion Homeostasis Activation Of NF-kappaB-inducing Kinase Activity Release Of Sequestered Calcium Ion Into Cytosol By Endoplasmic Reticulum Regulation Of Plasma Membrane Organization Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Phospholipid Transport Endosomal Lumen Acidification Necroptotic Process T Cell Chemotaxis Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Positive Regulation Of T Cell Chemotaxis Regulation Of T Cell Chemotaxis Positive Regulation Of Myoblast Fusion Immune Response Death Receptor Binding	L-arginine Catabolic Process To L-glutamate Ornithine Aminotransferase Activity L-arginine Catabolic Process To Proline Via Ornithine
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