TNFRSF6B

Description		TNF receptor superfamily member 6b
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space
	Molecular Function	Protein Binding Signaling Receptor Activity
	Biological Process	Apoptotic Process Negative Regulation Of Apoptotic Process
Pathways		TNFs bind their physiological receptors
Drugs
Diseases		Autoimmune lymphoproliferative syndromes (ALPS), including the following five diseases: CD95 (Fas) defect, ALPS type 1a; CD95L (Fas ligand) defect, ALPS type 1b; Caspase 10 defect, ALPS type 2a; Caspase 8 defext, ALPS type 2b; Activaing N-Ras defect, N-Ras ALPS
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31361310 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 26482879 25574825 23727859) Blood protein levels ( 30072576) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Glioma ( 22886559) Inflammatory bowel disease ( 28067908 23128233 18758464) Pediatric autoimmune diseases ( 26301688) Prostate cancer ( 23535732) Refractive error ( 32231278) Ulcerative colitis ( 28067908 21297633)
Interacting Genes		6 interacting genes: FASLG KRTAP10-3 KRTAP10-9 PPP1R7 TNFSF14 TNFSF15
Entrez ID		8771
HPRD ID		04527
Ensembl ID		ENSG00000243509
Uniprot IDs		O95407
PDB IDs		3K51 3MHD 3MI8 4J6G 4KGG 4KGQ 4MSV 5L36
Enriched GO Terms of Interacting Partners?		Tumor Necrosis Factor Receptor Binding Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Cytokine Activity Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Signaling Receptor Binding Regulation Of Apoptotic Signaling Pathway Keratin Filament Positive Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Process Positive Regulation Of Phosphatidylserine Exposure On Apoptotic Cell Surface Signaling Cell Communication Retinal Cell Programmed Cell Death Intermediate Filament Cytoplasmic Vesicle Lumen Positive Regulation Of Phospholipid Translocation Inflammatory Cell Apoptotic Process Necroptotic Signaling Pathway Intracellular Chloride Ion Homeostasis Activation Of NF-kappaB-inducing Kinase Activity Release Of Sequestered Calcium Ion Into Cytosol By Endoplasmic Reticulum Regulation Of Plasma Membrane Organization Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Phospholipid Transport Endosomal Lumen Acidification Necroptotic Process T Cell Chemotaxis Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Positive Regulation Of T Cell Chemotaxis Regulation Of T Cell Chemotaxis Positive Regulation Of Myoblast Fusion Immune Response Death Receptor Binding
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