TNFSF15 and TNFRSF25

Number of citations of the paper that reports this interaction (PMID 11911831)
105

Data Source:
HPRD (in vivo)

		TNFSF15	TNFRSF25
Gene Name		tumor necrosis factor (ligand) superfamily, member 15	tumor necrosis factor receptor superfamily, member 25
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane	Extracellular Region Cytosol Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Receptor Binding Death Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding	Receptor Activity Tumor Necrosis Factor-activated Receptor Activity
	Biological Process	Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Immune Response Signal Transduction Activation Of NF-kappaB-inducing Kinase Activity Cytokine Metabolic Process Positive Regulation Of Cytokine Secretion	Apoptotic Process Signal Transduction Cell Surface Receptor Signaling Pathway Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Apoptotic Process Apoptotic Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Crohn's disease ( 18587394 21102463 23266558) Inflammatory bowel disease ( 18758464 23128233 21699788) Leprosy ( 20018961) Primary biliary cirrhosis ( 23000144) Ulcerative colitis ( 20848476 21297633)
Protein-Protein Interactions		2 interactors: TNFRSF25 TNFRSF6B	8 interactors: BAG4 DAP3 MAPK1 TNFRSF1A TNFSF12 TNFSF15 TRADD TRAF2
Entrez ID		9966	8718
HPRD ID		04956	04532
Ensembl ID		ENSG00000181634	ENSG00000215788
Uniprot IDs		O95150	Q93038
PDB IDs		2O0O 2QE3 2RE9 2RJK 2RJL 3K51 3MI8
Enriched GO Terms of Interacting Partners?		Apoptotic Process Programmed Cell Death Cell Death Death Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Apoptotic Process Regulation Of Cell Death Cellular Response To Tumor Necrosis Factor Response To Tumor Necrosis Factor	Apoptotic Process Programmed Cell Death Cell Death Death Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Cellular Response To Tumor Necrosis Factor Positive Regulation Of Intracellular Signal Transduction Response To Tumor Necrosis Factor Protein Heterooligomerization Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Cellular Response To Cytokine Stimulus Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Response To Cytokine Positive Regulation Of Protein Phosphorylation Regulation Of Apoptotic Process Regulation Of Cell Death Regulation Of Signal Transduction Apoptotic Signaling Pathway Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Phosphorylation Activation Of Cysteine-type Endopeptidase Activity Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Modification Process Regulation Of Signaling Zymogen Activation Signal Transduction Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Protein Oligomerization Positive Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Phosphorylation Positive Regulation Of Metabolic Process Positive Regulation Of Endopeptidase Activity Signaling Cell Communication Positive Regulation Of Peptidase Activity Regulation Of Phosphorylation Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of NF-kappaB-inducing Kinase Activity Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Cellular Metabolic Process Cellular Response To Stimulus Response To Epidermal Growth Factor Regulation Of Phosphorus Metabolic Process
Tagcloud ?		5httlpr 7alpha ba cholesten colonic constipation ct48 fdr fecal fgf19 fgfr4 gpbar1 ibs insert irritable klb multifaceted pathobiological pathobiology predisposing reuptake rs11554825 rs17618244 rs351855 rs4263839 rs4795541 sensation slc6a4 transit	asp bel7404 carboxy cip1 cited2 clonogenicity glu granzyme hccs hep3b ink4b kip1 lo2 maspin metallopeptidase nontumor oligonucleotide ontology p15 peroxisome ppargamma proapoptotic proinvasion proliferator rosiglitazone suppressive transactivator wat1
Tagcloud (Difference) ?		5httlpr 7alpha ba cholesten colonic constipation ct48 fdr fecal fgf19 fgfr4 gpbar1 ibs insert irritable klb multifaceted pathobiological pathobiology predisposing reuptake rs11554825 rs17618244 rs351855 rs4263839 rs4795541 sensation slc6a4 transit	asp bel7404 carboxy cip1 cited2 clonogenicity glu granzyme hccs hep3b ink4b kip1 lo2 maspin metallopeptidase nontumor oligonucleotide ontology p15 peroxisome ppargamma proapoptotic proinvasion proliferator rosiglitazone suppressive transactivator wat1
Tagcloud (Intersection) ?