TNFRSF6B and KRTAP10-9

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		TNFRSF6B	KRTAP10-9
Description		TNF receptor superfamily member 6b	keratin associated protein 10-9
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Cytosol Intermediate Filament Keratin Filament
	Molecular Function	Protein Binding Signaling Receptor Activity	Protein Binding
	Biological Process	Apoptotic Process Negative Regulation Of Apoptotic Process
Pathways		TNFs bind their physiological receptors	Keratinization
Drugs
Diseases		Autoimmune lymphoproliferative syndromes (ALPS), including the following five diseases: CD95 (Fas) defect, ALPS type 1a; CD95L (Fas ligand) defect, ALPS type 1b; Caspase 10 defect, ALPS type 2a; Caspase 8 defext, ALPS type 2b; Activaing N-Ras defect, N-Ras ALPS
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31361310 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 26482879 25574825 23727859) Blood protein levels ( 30072576) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Glioma ( 22886559) Inflammatory bowel disease ( 28067908 23128233 18758464) Pediatric autoimmune diseases ( 26301688) Prostate cancer ( 23535732) Refractive error ( 32231278) Ulcerative colitis ( 28067908 21297633)
Interacting Genes		6 interacting genes: FASLG KRTAP10-3 KRTAP10-9 PPP1R7 TNFSF14 TNFSF15	239 interacting genes: ADAMTSL4 ALDH3B1 ALPI ANKS1A ARFGAP1 ATXN7L1 AVPI1 BCL6B BMP7 BRME1 C10orf62 C11orf87 C22orf39 CATIP CATSPER1 CBX2 CCDC26 CD300LG CDKL3 CHIC2 CHRD CHRNG CKS1B CLK4 CNNM3 CRCT1 CREB5 CST9L CXCL16 CYSRT1 DHRS1 DHX57 DMRT3 DOCK2 EIF4E2 EZH2 FAM124B FAM161A FAM74A4 FAM76B FARS2 FBXW5 GABARAPL1 GABARAPL2 GATA2 GLIDR GLP1R GLRX3 GNE GPATCH2L GSTP1 GUCD1 HBG1 HBZ HCK HES6 HOXA1 HOXB9 HOXC8 HPCAL1 HSBP1 HSD3B7 IGSF8 INPP5D IQUB ITGB4 ITGB5 KAT5 KIAA0040 KIF9 KLHL38 KRT20 KRT83 KRTAP1-1 KRTAP1-3 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP12-1 KRTAP12-3 KRTAP26-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-7 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-4 KRTAP9-8 LCE1A LCE1B LCE1C LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE2D LCE3A LCE3B LCE3C LCE3D LCE3E LCE4A LCE5A LUZP4 MAB21L3 MAPKBP1 MAZ MED30 MEOX2 MOBP MT1DP MXI1 MYPOP NAXD NBPF19 NECTIN3 NKD1 NOTCH2NLA NPBWR2 NPDC1 NPPB NR1D2 NUFIP2 OTX1 PCSK5 PDE9A PDGFRB PGAP2 PGLS PIGS PIN1 PLSCR1 POU4F2 PRKAA2 PRKAB2 PRPF31 PTGER3 PTPMT1 PVR RAB7A RASD1 RHNO1 RSPO2 SCARB1 SCNM1 SEMA3B SHFL SLC23A1 SLC6A20 SMARCE1 SMCP SPACA9 SPATA3 SPATA31J1 SPATA8 SPG7 SPRY1 SPRY2 STK16 TBC1D16 TBC1D23 TBC1D26 TEDC2 TGOLN2 THAP10 TLE5 TNFRSF6B TNP2 TRIM41 TRIM42 TXNDC5 TYMSOS TYRO3 UTP23 VGLL3 WNT11 WT1 WT1-AS XCL2 YIPF3 YY1 ZBTB24 ZBTB38 ZBTB9 ZFYVE26 ZNF124 ZNF155 ZNF165 ZNF20 ZNF251 ZNF264 ZNF275 ZNF286A ZNF317 ZNF319 ZNF417 ZNF433 ZNF439 ZNF440 ZNF473 ZNF490 ZNF491 ZNF497 ZNF524 ZNF564 ZNF572 ZNF578 ZNF581 ZNF587 ZNF599 ZNF625 ZNF688 ZNF696 ZNF697 ZNF699 ZNF764 ZNF774 ZNF777 ZNF792 ZNF80 ZNF837 ZNF844 ZNF860 ZSCAN21 ZSCAN26
Entrez ID		8771	386676
HPRD ID		04527	11195
Ensembl ID		ENSG00000243509	ENSG00000221837
Uniprot IDs		O95407	P60411
PDB IDs		3K51 3MHD 3MI8 4J6G 4KGG 4KGQ 4MSV 5L36
Enriched GO Terms of Interacting Partners?		Tumor Necrosis Factor Receptor Binding Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Cytokine Activity Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Signaling Receptor Binding Regulation Of Apoptotic Signaling Pathway Keratin Filament Positive Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Process Positive Regulation Of Phosphatidylserine Exposure On Apoptotic Cell Surface Signaling Cell Communication Retinal Cell Programmed Cell Death Intermediate Filament Cytoplasmic Vesicle Lumen Positive Regulation Of Phospholipid Translocation Inflammatory Cell Apoptotic Process Necroptotic Signaling Pathway Intracellular Chloride Ion Homeostasis Activation Of NF-kappaB-inducing Kinase Activity Release Of Sequestered Calcium Ion Into Cytosol By Endoplasmic Reticulum Regulation Of Plasma Membrane Organization Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Phospholipid Transport Endosomal Lumen Acidification Necroptotic Process T Cell Chemotaxis Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Positive Regulation Of T Cell Chemotaxis Regulation Of T Cell Chemotaxis Positive Regulation Of Myoblast Fusion Immune Response Death Receptor Binding	Intermediate Filament Keratin Filament Keratinization Epidermis Development DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Transcription By RNA Polymerase II Zinc Ion Binding DNA Binding Hair Cycle Tissue Development Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity Lung Growth
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