ADAM21 and CNR2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ADAM21	CNR2
Description		ADAM metallopeptidase domain 21	cannabinoid receptor 2
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane Axon Neuron Projection Neuronal Cell Body Sperm Head Plasma Membrane	Cytoplasm Endoplasmic Reticulum Plasma Membrane Membrane Dendrite Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Cell Projection Neuronal Cell Body Perikaryon Postsynaptic Membrane
	Molecular Function	Metalloendopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Hydrolase Activity Metal Ion Binding	G Protein-coupled Receptor Activity Cannabinoid Receptor Activity Protein Binding
	Biological Process	Proteolysis Single Fertilization Male Gonad Development	Response To Amphetamine Inflammatory Response Immune Response Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Leukocyte Chemotaxis Negative Regulation Of Synaptic Transmission, GABAergic Response To Lipopolysaccharide Negative Regulation Of Mast Cell Activation Cannabinoid Signaling Pathway Negative Regulation Of Action Potential Trans-synaptic Signaling By Endocannabinoid, Modulating Synaptic Transmission
Pathways		Interaction With Cumulus Cells And The Zona Pellucida	Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events
Drugs			Dronabinol Nabilone Ricinoleic acid Lasofoxifene Cannabidiol Tetrahydrocannabivarin Medical Cannabis Nabiximols S-777469
Diseases
GWAS		Motor coordination ( 34177493) Plasma estrone levels in resected estrogen-receptor positive breast cancer ( 28429243)	Eosinophil count ( 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular volume ( 32888494) Multiple sclerosis ( 31604244) Psychotic experience (distressing) ( 31553412)
Interacting Genes		2 interacting genes: CNR2 SGTA	24 interacting genes: ADAM21 ADIPOQ AGPAT4 CCL4 COMT FXYD3 GNA15 MUC15 NRM PEDS1-UBE2V1 RFT1 SELENOK SLC35E4 SLC39A2 TMEM19 TMEM203 TMEM242 TMEM60 TMEM86A TMPPE TSPO2 YIPF1 YIPF4 YIPF6
Entrez ID		8747	1269
HPRD ID		04755	05444
Ensembl ID		ENSG00000139985	ENSG00000188822
Uniprot IDs		Q9UKJ8	P34972
PDB IDs			2KI9 5ZTY 6KPC 6KPF 6PT0 8GUQ 8GUR 8GUS 8GUT 8X3L
Enriched GO Terms of Interacting Partners?		Cannabinoid Receptor Activity Negative Regulation Of Action Potential Trans-synaptic Signaling By Endocannabinoid, Modulating Synaptic Transmission Cannabinoid Signaling Pathway Negative Regulation Of Synaptic Transmission, GABAergic TRC Complex BAT3 Complex Binding Negative Regulation Of ERAD Pathway Negative Regulation Of Mast Cell Activation Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Trans-synaptic Signaling, Modulating Synaptic Transmission Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Tail-anchored Membrane Protein Insertion Into ER Membrane Regulation Of Mast Cell Activation Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Response To Amphetamine Protein Insertion Into ER Membrane Protein Targeting To ER Regulation Of Synaptic Transmission, GABAergic Establishment Of Protein Localization To Endoplasmic Reticulum Negative Regulation Of Synaptic Transmission Positive Regulation Of Response To Endoplasmic Reticulum Stress Response To Amine Negative Regulation Of Response To Endoplasmic Reticulum Stress G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Action Potential Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Protein Targeting To Membrane Protein Insertion Into Membrane Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Response To Endoplasmic Reticulum Stress ERAD Pathway	Membrane Golgi Trans Cisterna Golgi Medial Cisterna Endoplasmic Reticulum Positive Regulation Of Monocyte Chemotactic Protein-1 Production
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