ADAM21

Description		ADAM metallopeptidase domain 21
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane Axon Neuron Projection Neuronal Cell Body Sperm Head Plasma Membrane
	Molecular Function	Metalloendopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Hydrolase Activity Metal Ion Binding
	Biological Process	Proteolysis Single Fertilization Male Gonad Development
Pathways		Interaction With Cumulus Cells And The Zona Pellucida
Drugs
Diseases
GWAS		Motor coordination ( 34177493) Plasma estrone levels in resected estrogen-receptor positive breast cancer ( 28429243)
Interacting Genes		2 interacting genes: CNR2 SGTA
Entrez ID		8747
HPRD ID		04755
Ensembl ID		ENSG00000139985
Uniprot IDs		Q9UKJ8
PDB IDs
Enriched GO Terms of Interacting Partners?		Cannabinoid Receptor Activity Negative Regulation Of Action Potential Trans-synaptic Signaling By Endocannabinoid, Modulating Synaptic Transmission Cannabinoid Signaling Pathway Negative Regulation Of Synaptic Transmission, GABAergic TRC Complex BAT3 Complex Binding Negative Regulation Of ERAD Pathway Negative Regulation Of Mast Cell Activation Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Trans-synaptic Signaling, Modulating Synaptic Transmission Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Tail-anchored Membrane Protein Insertion Into ER Membrane Regulation Of Mast Cell Activation Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Response To Amphetamine Protein Insertion Into ER Membrane Protein Targeting To ER Regulation Of Synaptic Transmission, GABAergic Establishment Of Protein Localization To Endoplasmic Reticulum Negative Regulation Of Synaptic Transmission Positive Regulation Of Response To Endoplasmic Reticulum Stress Response To Amine Negative Regulation Of Response To Endoplasmic Reticulum Stress G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Action Potential Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Protein Targeting To Membrane Protein Insertion Into Membrane Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Response To Endoplasmic Reticulum Stress ERAD Pathway
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