NRG1 and KCNK4

Data Source: HiPPIP (Novel)

		NRG1	KCNK4
Name		neuregulin 1	potassium two pore domain channel subfamily K member 4
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Nucleoplasm Plasma Membrane Membrane Apical Plasma Membrane Glutamatergic Synapse	Plasma Membrane Membrane Axon Node Of Ranvier Monoatomic Ion Channel Complex Potassium Channel Complex Cell Projection
	Molecular Function	Transcription Coregulator Activity Signaling Receptor Binding Cytokine Activity Integrin Binding Protein Binding Growth Factor Activity Zinc Ion Binding Nickel Cation Binding Protein Tyrosine Kinase Activator Activity Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Receptor Tyrosine Kinase Binding ErbB-3 Class Receptor Binding Chemorepellent Activity Receptor Ligand Activity	Potassium Channel Activity Protein Binding Outward Rectifier Potassium Channel Activity Potassium Ion Leak Channel Activity Identical Protein Binding Metal Ion Binding Temperature-gated Cation Channel Activity Mechanosensitive Potassium Channel Activity
	Biological Process	Ventricular Trabecula Myocardium Morphogenesis Cell Communication Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Brain Development Peripheral Nervous System Development Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Regulation Of Cell Communication Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Neural Crest Cell Development Regulation Of Signaling Cell Differentiation Positive Regulation Of Cell Growth Mammary Gland Development Positive Regulation Of Protein-containing Complex Assembly Activation Of Protein Kinase B Activity Intracellular Signal Transduction ERBB Signaling Pathway ERBB2 Signaling Pathway ERBB3 Signaling Pathway ERBB4 Signaling Pathway ERBB2-ERBB3 Signaling Pathway ERBB2-ERBB4 Signaling Pathway ERBB4-ERBB4 Signaling Pathway Wound Healing Positive Regulation Of Cell Adhesion Negative Regulation Of DNA-templated Transcription Negative Chemotaxis Negative Regulation Of Secretion Positive Regulation Of Developmental Process Positive Regulation Of Striated Muscle Cell Differentiation Cardiac Muscle Cell Differentiation Ventricular Cardiac Muscle Cell Differentiation Positive Regulation Of Cardiac Muscle Cell Proliferation Cardiac Muscle Cell Myoblast Differentiation Endocardial Cell Differentiation Regulation Of Biological Quality Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Positive Regulation Of Peptidyl-tyrosine Autophosphorylation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Monoatomic Ion Transport Potassium Ion Transport Memory Response To Mechanical Stimulus Neuronal Action Potential Sensory Perception Of Pain Monoatomic Ion Transmembrane Transport Sensory Perception Of Temperature Stimulus Detection Of Mechanical Stimulus Involved In Sensory Perception Of Touch Cellular Response To Mechanical Stimulus Cellular Response To Fatty Acid Cellular Response To Acidic PH Cellular Response To Alkaline PH Cellular Response To Temperature Stimulus Potassium Ion Transmembrane Transport Cellular Response To Arachidonate Response To Ultrasound
Pathways		Signaling by ERBB2 Signaling by ERBB4 SHC1 events in ERBB2 signaling SHC1 events in ERBB2 signaling PI3K events in ERBB4 signaling SHC1 events in ERBB4 signaling Nuclear signaling by ERBB4 PIP3 activates AKT signaling GRB7 events in ERBB2 signaling Downregulation of ERBB2:ERBB3 signaling GRB2 events in ERBB2 signaling PI3K events in ERBB2 signaling Constitutive Signaling by Aberrant PI3K in Cancer RAF/MAP kinase cascade ERBB2 Regulates Cell Motility PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling ERBB2 Activates PTK6 Signaling Downregulation of ERBB2 signaling Long-term potentiation Signaling by ERBB2 KD Mutants Signaling by ERBB2 TMD/JMD mutants	TWIK related potassium channel (TREK) Phase 4 - resting membrane potential
GWAS		Bone mineral density (hip) ( 30172743 ) Cardiac Troponin-T levels ( 23247143 ) Cerebrospinal P-tau181p levels ( 28247064 ) Cerebrospinal T-tau levels ( 28247064 ) Chin dimples ( 27182965 ) Chronotype ( 30696823 ) Cognitive function ( 25644384 ) Coronary artery calcification ( 23870195 ) Dialysis-related mortality ( 21546767 ) Differentiated thyroid cancer ( 28703219 ) Diffusing capacity of carbon monoxide ( 30694715 ) Emphysema imaging phenotypes ( 26030696 ) Estimated glomerular filtration rate ( 31152163 30604766 ) Gut microbiota alpha diversity (PD_whole_tree index) ( 33208821 ) Hematocrit ( 32888494 ) Hemoglobin ( 32888494 ) Hip geometry ( 17903296 ) Hirschsprung disease ( 19196962 27702942 25310821 ) Hypothyroidism ( 27182965 ) Logical memory (delayed recall) in mild cognitive impairment ( 29274321 ) Logical memory (immediate recall) in mild cognitive impairment ( 29274321 ) Lung adenocarcinoma ( 28604730 ) Lung cancer ( 28604730 ) Major depressive disorder ( 29317602 ) Malaria ( 31844061 ) Metabolite levels (X-11787) ( 23934736 ) Morning person ( 30696823 ) Non-small cell lung cancer ( 31326317 ) Obstructive sleep apnea ( 25325441 ) Papillary thyroid cancer ( 28703219 ) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245 ) Pulse pressure ( 27841878 ) Refractive astigmatism ( 25367360 ) Response to serotonin reuptake inhibitors in major depressive disorder ( 25897834 ) Rheumatic heart disease ( 34106200 ) Serum thyroid-stimulating hormone levels ( 25436638 ) Thyroid cancer ( 22267200 ) Thyroid hormone levels ( 23408906 ) Thyroid stimulating hormone levels ( 32769997 ) Urate levels ( 31578528 ) Weight ( 28552196 )	Crohn's disease ( 28067908 ) Sarcoidosis ( 22837380 ) Vitiligo ( 27723757 )
Novel Interactors		8 novel interactors: ADGRA2 CEBPD DKK4 EIF4EBP1 FGFR1 ISG20 KCNK4 LIPF	1 novel interactors: NRG1
Interacting Genes		15 interacting genes: ADAM19 ASGR2 CD72 EGF EGFR ERBB2 ERBB3 ERBB4 IKZF4 JAGN1 LAPTM4B LIMK1 MS4A4A PLP1 TMEM54	3 interacting genes: DIDO1 ORMDL1 RPL14
Entrez ID		3084	50801
HPRD ID		00802	12037
Ensembl ID		ENSG00000157168	ENSG00000182450
Uniprot IDs		A0A024QY88 A0A494C0K4 A0A494C0L9 A0A494C0Q4 A0A494C114 A0A494C1B5 A0A494C1F5 A0A494C1F8 A5YAK6 A5YAK8 A6MW54 A6MW55 A6MW56 B0FWZ3 B0FYA7 B0FYA8 B0FYA9 B7Z1D7 B7Z1E3 E3SFM9 E5RHP6 Q02297 Q6PK61 Q7RTW3 Q7RTW5	Q2YDA1 Q9NYG8
PDB IDs		1HAE 1HAF 1HRE 1HRF 3U7U 7MN5 7MN6 7MN8 7SJL 8U4I 8U4L	3UM7 4I9W 4RUE 4RUF 4WFE 4WFF 4WFG 4WFH 7LJ4 7LJ5 7LJA 7LJB
GO Terms Enriched among Interactors		ERBB2 Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway ERBB2-EGFR Signaling Pathway Positive Regulation Of Epithelial Cell Proliferation Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Tyrosine Kinase Activity Basal Plasma Membrane ERBB3:ERBB2 Complex Receptor Complex Epidermal Growth Factor Receptor Activity Neuregulin Receptor Activity Regulation Of Epithelial Cell Proliferation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Transmembrane Signaling Receptor Activity Positive Regulation Of Protein Phosphorylation Cell Surface Receptor Signaling Pathway Positive Regulation Of Phosphorylation Positive Regulation Of Growth ErbB-3 Class Receptor Binding ERBB2-ERBB4 Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of MAPK Cascade Cellular Response To Epidermal Growth Factor Stimulus Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Kinase Activity Peptidyl-tyrosine Phosphorylation Response To Epidermal Growth Factor Positive Regulation Of Phosphate Metabolic Process ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway ERBB4 Signaling Pathway Salivary Gland Morphogenesis Glial Cell Development Intracellular Signaling Cassette Positive Regulation Of Protein Modification Process Kinase Activity Regulation Of Protein Phosphorylation Enzyme-linked Receptor Protein Signaling Pathway Regulation Of MAPK Cascade Protein Tyrosine Kinase Activator Activity Regulation Of Phosphorylation Mammary Gland Alveolus Development Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction System Development Basolateral Plasma Membrane Schwann Cell Development Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Myelination Axon Ensheathment	Activation Of Protein Kinase B Activity Ventricular Cardiac Muscle Cell Differentiation ErbB-3 Class Receptor Binding Positive Regulation Of Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Protein Autophosphorylation ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway ERBB2-ERBB4 Signaling Pathway Endocardial Cell Differentiation ERBB4 Signaling Pathway Nickel Cation Binding ERBB4-ERBB4 Signaling Pathway Intracellular Sphingolipid Homeostasis Serine Palmitoyltransferase Complex Negative Regulation Of Ceramide Biosynthetic Process Negative Regulation Of Sphingolipid Biosynthetic Process Cardiac Muscle Cell Myoblast Differentiation Sphingomyelin Biosynthetic Process Ventricular Trabecula Myocardium Morphogenesis Cardioblast Differentiation Regulation Of Protein Autophosphorylation Regulation Of Ceramide Biosynthetic Process Regulation Of Sphingolipid Biosynthetic Process Protein Tyrosine Kinase Activator Activity Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Large Ribosomal Subunit Sphingomyelin Metabolic Process Regulation Of Membrane Lipid Metabolic Process Heart Trabecula Morphogenesis