CTSF and CD74

Number of citations of the paper that reports this interaction (PMID 10748235)
29

Data Source:
HPRD (in vivo, in vitro)

		CTSF	CD74
Gene Name		cathepsin F	CD74 molecule, major histocompatibility complex, class II invariant chain
Image
Gene Ontology Annotations	Cellular Component	Lysosome Vesicle Lysosomal Lumen Extracellular Vesicular Exosome	Golgi Membrane Intracellular Lysosomal Membrane Multivesicular Body Vacuole Plasma Membrane External Side Of Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Membrane Integral Component Of Membrane Transport Vesicle Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Trans-Golgi Network Membrane Macrophage Migration Inhibitory Factor Receptor Complex NOS2-CD74 Complex MHC Class II Protein Complex Lysosomal Lumen Extracellular Vesicular Exosome Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
	Molecular Function	Cysteine-type Endopeptidase Activity	Beta-amyloid Binding Cytokine Receptor Activity Protein Binding Cytokine Binding MHC Class II Protein Complex Binding Macrophage Migration Inhibitory Factor Binding MHC Class II Protein Binding MHC Class II Protein Binding, Via Antigen Binding Groove Identical Protein Binding Protein Binding Involved In Protein Folding Nitric-oxide Synthase Binding
	Biological Process	Proteolysis Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II	Activation Of MAPK Activity Prostaglandin Biosynthetic Process Positive Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Negative Regulation Of Peptide Secretion Positive Regulation Of Type 2 Immune Response Negative Regulation Of Mature B Cell Apoptotic Process Protein Complex Assembly Intracellular Protein Transport Defense Response Signal Transduction Cell Proliferation Immunoglobulin Mediated Immune Response Antigen Processing And Presentation Of Endogenous Antigen Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Positive Regulation Of B Cell Proliferation Macrophage Migration Inhibitory Factor Signaling Pathway Regulation Of Macrophage Activation Negative Regulation Of Apoptotic Process Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator T Cell Selection Positive Thymic T Cell Selection Negative Thymic T Cell Selection Negative Regulation Of T Cell Differentiation Positive Regulation Of T Cell Differentiation Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Chaperone Mediated Protein Folding Requiring Cofactor Positive Regulation Of Macrophage Cytokine Production Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Neutrophil Chemotaxis Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production
Pathways		MHC class II antigen presentation Adaptive Immune System	MHC class II antigen presentation Adaptive Immune System
Drugs		[1-(1-Methyl-4,5-Dioxo-Pent-2-Enylcarbamoyl)-2-Phenyl-Ethyl]-Carbamic Acid Benzyl Ester [1-(1-Benzyl-3-Hydroxy-2-Oxo-Propylcarbamoyl)-2-Phenyl-Ethyl]-Carbamic Acid Benzyl Ester 4-Morpholin-4-Yl-Piperidine-1-Carboxylic Acid [1-(3-Benzenesulfonyl-1-Propyl-Allylcarbamoyl)-2-Phenylethyl]-Amide Benzoyl-Arginine-Alanine-Methyl Ketone WRR-99 WRR-112 HOMOPHENYLALANINYLMETHANE BENZOYL-TYROSINE-ALANINE-METHYL KETONE
Diseases
GWAS		Bipolar disorder ( 21926972)
Protein-Protein Interactions		1 interactors: CD74	14 interactors: APP CD1D CD44 CTSF CTSL HADHA HLA-DMA HLA-DMB HLA-DPA1 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRA MIF
Entrez ID		8722	972
HPRD ID		04643	00825
Ensembl ID		ENSG00000174080	ENSG00000019582
Uniprot IDs		Q9UBX1	P04233
PDB IDs		1D5U 1M6D	1A6A 1ICF 1IIE 1L3H 1MUJ 3PDO 3PGC 3PGD 3QXA 3QXD 4AEN 4AH2
Enriched GO Terms of Interacting Partners?		Macrophage Migration Inhibitory Factor Signaling Pathway Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Negative Regulation Of Mature B Cell Apoptotic Process Positive Thymic T Cell Selection Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Negative Regulation Of B Cell Apoptotic Process Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Thymic T Cell Selection Negative T Cell Selection Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Antigen Processing And Presentation Of Endogenous Antigen Regulation Of B Cell Apoptotic Process Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Thymic T Cell Selection Positive Regulation Of Macrophage Cytokine Production Prostaglandin Biosynthetic Process Positive Regulation Of Neutrophil Chemotaxis Negative Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Myeloid Leukocyte Cytokine Production Involved In Immune Response Regulation Of Macrophage Activation Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Granulocyte Chemotaxis Positive Regulation Of Type 2 Immune Response Chaperone Mediated Protein Folding Requiring Cofactor Positive T Cell Selection Positive Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Response To Cytokine Stimulus Regulation Of Neutrophil Chemotaxis Prostaglandin Metabolic Process Regulation Of Neutrophil Migration Negative Regulation Of T Cell Differentiation Regulation Of Granulocyte Chemotaxis Positive Regulation Of B Cell Proliferation T Cell Selection Positive Regulation Of Chemokine Production Negative Regulation Of Peptide Secretion Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Type 2 Immune Response Icosanoid Biosynthetic Process Negative Regulation Of Lymphocyte Differentiation Positive Regulation Of Cytokine Production Involved In Immune Response Unsaturated Fatty Acid Biosynthetic Process Negative Regulation Of Leukocyte Apoptotic Process Regulation Of Chemokine Production 'de Novo' Posttranslational Protein Folding Regulation Of B Cell Proliferation 'de Novo' Protein Folding Regulation Of Lymphocyte Apoptotic Process	Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Antigen Processing And Presentation Positive Regulation Of Homotypic Cell-cell Adhesion Antigen Processing And Presentation Of Peptide Antigen Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Activation Immune Response Positive Regulation Of T Cell Activation Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Lymphocyte Activation Positive Regulation Of Immune Response Immune System Process Regulation Of Cell Activation Regulation Of T Cell Activation Innate Immune Response Regulation Of Immune Response Positive Regulation Of Immune System Process Regulation Of Cell Adhesion Interferon-gamma-mediated Signaling Pathway Cellular Response To Interferon-gamma Regulation Of Immune System Process Defense Response Response To Interferon-gamma T Cell Costimulation Peptide Antigen Assembly With MHC Class II Protein Complex MHC Class II Protein Complex Assembly T Cell Receptor Signaling Pathway Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Antigen Receptor-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Immune Response-regulating Signaling Pathway Positive Regulation Of T Cell Proliferation Immune Response-activating Cell Surface Receptor Signaling Pathway Cellular Response To Cytokine Stimulus Regulation Of T Cell Proliferation Immune Response-regulating Cell Surface Receptor Signaling Pathway Response To Cytokine Response To Organic Substance Response To Stress Response To Stimulus Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Cellular Response To Organic Substance Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Cell Proliferation
Tagcloud ?		0e 1426a 219g 3072g abhd16a abhd5 acp2 alms1 apoa2 atp1a2 bft col14a1 dars decr1 ghrl intron3 mc4r mttp nfkbia nt5e pfp plat ppp2r5d rfc2 rragd sdhd serpinf1 tbc1d1 ube2h	actionable adenocarcinomas akt1 alk braf capture ccdc6 clip4 deemed driver fusions g719a genomic introns kif5b map2k1 nccn ngs nras pack pik3ca profiling rearranged ret ros1 socs5 targetable uniform v600e
Tagcloud (Difference) ?		0e 1426a 219g 3072g abhd16a abhd5 acp2 alms1 apoa2 atp1a2 bft col14a1 dars decr1 ghrl intron3 mc4r mttp nfkbia nt5e pfp plat ppp2r5d rfc2 rragd sdhd serpinf1 tbc1d1 ube2h	actionable adenocarcinomas akt1 alk braf capture ccdc6 clip4 deemed driver fusions g719a genomic introns kif5b map2k1 nccn ngs nras pack pik3ca profiling rearranged ret ros1 socs5 targetable uniform v600e
Tagcloud (Intersection) ?