CTSF

Description		cathepsin F
Image
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Lysosome Endoplasmic Reticulum Plasma Membrane Endomembrane System Extracellular Matrix Lysosomal Lumen Intracellular Organelle Lumen Extracellular Exosome Extracellular Vesicle
	Molecular Function	Cysteine-type Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity
	Biological Process	Immune System Process Proteolysis Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Proteolysis Involved In Protein Catabolic Process
Pathways		MHC class II antigen presentation
Drugs		[1-(1-Methyl-4,5-Dioxo-Pent-2-Enylcarbamoyl)-2-Phenyl-Ethyl]-Carbamic Acid Benzyl Ester [1-(1-Benzyl-3-Hydroxy-2-Oxo-Propylcarbamoyl)-2-Phenyl-Ethyl]-Carbamic Acid Benzyl Ester 4-Morpholin-4-Yl-Piperidine-1-Carboxylic Acid [1-(3-Benzenesulfonyl-1-Propyl-Allylcarbamoyl)-2-Phenylethyl]-Amide Benzyl N-[(2S)-5-(diaminomethylamino)-1-[[(2S)-4-fluoro-3-oxobutan-2-yl]amino]-1-oxopentan-2-yl]carbamate WRR-99 WRR-112 HOMOPHENYLALANINYLMETHANE Benzoyl-tyrosine-alanine-fluoro-methyl ketone
Diseases
GWAS		Airway imaging phenotypes ( 26030696) Bipolar disorder ( 21926972) Blood protein levels ( 30072576) Chronotype ( 30696823)
Interacting Genes		2 interacting genes: CD74 TRIM55
Entrez ID		8722
HPRD ID		04643
Ensembl ID		ENSG00000174080
Uniprot IDs		Q9UBX1
PDB IDs		1M6D
Enriched GO Terms of Interacting Partners?		MHC Class II Protein Binding, Via Antigen Binding Groove NOS2-CD74 Complex Macrophage Migration Inhibitory Factor Signaling Pathway Macrophage Migration Inhibitory Factor Binding Positive Regulation Of Macrophage Migration Inhibitory Factor Signaling Pathway Macrophage Migration Inhibitory Factor Receptor Complex Regulation Of Macrophage Migration Inhibitory Factor Signaling Pathway Vacuole Nitric-oxide Synthase Binding Innate Immune Response Positive Thymic T Cell Selection Positive Regulation Of Type 2 Immune Response Positive Regulation Of Monocyte Differentiation Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Negative Thymic T Cell Selection Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Mature B Cell Apoptotic Process Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Defense Response To Symbiont Positive T Cell Selection Defense Response To Other Organism MHC Class II Protein Binding Positive Regulation Of Prostaglandin Biosynthetic Process Regulation Of Monocyte Differentiation Prostaglandin Biosynthetic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of B Cell Apoptotic Process MHC Class II Protein Complex Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator CD4 Receptor Binding Protein Trimerization Regulation Of Prostaglandin Biosynthetic Process Prostanoid Biosynthetic Process Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Positive Regulation Of Unsaturated Fatty Acid Biosynthetic Process Positive Regulation Of Viral Entry Into Host Cell Negative T Cell Selection Leukocyte Migration Involved In Inflammatory Response Diapedesis Regulation Of Antigen Processing And Presentation Positive Regulation Of Fatty Acid Biosynthetic Process Positive Regulation Of Macrophage Cytokine Production Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Host-mediated Suppression Of Symbiont Invasion Positive Regulation Of Neutrophil Chemotaxis Regulation Of Viral Entry Into Host Cell Regulation Of B Cell Apoptotic Process Thymic T Cell Selection Macrophage Migration Positive Regulation Of Viral Life Cycle
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