PAGE1 and SLC1A1

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		PAGE1	SLC1A1
Name		PAGE family member 1	solute carrier family 1 member 1
Structure		No pdb structure
GO Annotations	Cellular Component	None	Cytoplasm Endosome Plasma Membrane Cell Surface Membrane Apical Plasma Membrane Axon Dendrite Early Endosome Membrane Late Endosome Membrane Vesicle Asymmetric Synapse Neuron Projection Neuronal Cell Body Synaptic Cleft Dendritic Spine Dendritic Shaft Perikaryon Axon Terminus Membrane Raft Synapse Recycling Endosome Recycling Endosome Membrane Extracellular Exosome Cell Periphery Glial Cell Projection Apical Dendrite Schaffer Collateral - CA1 Synapse Presynapse Perisynaptic Space Distal Dendrite Proximal Dendrite
	Molecular Function	Protein Binding	Monoatomic Anion Channel Activity L-glutamate Transmembrane Transporter Activity High-affinity L-glutamate Transmembrane Transporter Activity Protein Binding Chloride Transmembrane Transporter Activity L-aspartate Transmembrane Transporter Activity Symporter Activity Glutamate:sodium Symporter Activity Cysteine Transmembrane Transporter Activity Identical Protein Binding Metal Ion Binding D-aspartate Transmembrane Transporter Activity
	Biological Process	None	Behavioral Fear Response Response To Amphetamine Regulation Of Heart Rate Glutathione Metabolic Process Glutathione Biosynthetic Process Superoxide Metabolic Process Monoatomic Ion Transport Neurotransmitter Transport Amino Acid Transport Intracellular Zinc Ion Homeostasis G Protein-coupled Dopamine Receptor Signaling Pathway Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Brain Development Learning Or Memory Memory Grooming Behavior Locomotory Behavior Response To Xenobiotic Stimulus Positive Regulation Of Heart Rate Gene Expression Retina Layer Formation L-glutamate Transmembrane Transport Cytokine-mediated Signaling Pathway Neurogenesis Adult Behavior Cellular Response To Oxidative Stress Maintenance Of Blood-brain Barrier Response To Decreased Oxygen Levels Dopamine Metabolic Process Cysteine Transport Response To Morphine Negative Regulation Of Neuron Apoptotic Process Establishment Of Protein Localization Blood Vessel Morphogenesis Response To Axon Injury Synapse Organization Neuron Apoptotic Process L-glutamate Import Righting Reflex Retina Development In Camera-type Eye Heart Contraction Long-term Synaptic Potentiation Motor Behavior Transepithelial Transport D-aspartate Transmembrane Transport L-aspartate Transmembrane Transport D-aspartate Import Across Plasma Membrane Cellular Response To Ammonium Ion Cellular Response To Mercury Ion Cellular Response To Cocaine Zinc Ion Transmembrane Transport Response To Anesthetic Regulation Of Protein Targeting To Membrane Intracellular Glutamate Homeostasis Motor Neuron Apoptotic Process Import Into Cell L-glutamate Import Across Plasma Membrane Neurotransmitter Receptor Transport To Plasma Membrane Postsynaptic Modulation Of Chemical Synaptic Transmission L-aspartate Import Across Plasma Membrane Transport Across Blood-brain Barrier Chloride Transmembrane Transport Cysteine Transmembrane Transport Cellular Response To Bisphenol A Conditioned Place Preference
Pathways		None	Glutamate Neurotransmitter Release Cycle Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA) SLC-mediated transport of amino acids
Drugs		None	Aspartic acid Glutamic acid
Diseases		None	Dicarboxylic aminoaciduria
GWAS		No GWAS studies recorded	Coronary artery calcification ( 23870195 ) Metabolite levels ( 23823483 ) Pancreatic cancer ( 22158540 ) Response to antipsychotic treatment in schizophrenia ( 29503163 ) Response to risperidone in schizophrenia ( 29503163 ) Squamous cell lung carcinoma ( 28604730 )
Interacting Genes		12 interacting genes: CMTM7 DDX49 FAM9B MGST3 PLPP4 SLC1A1 SLC2A5 TFRC TMEM14B TMEM254 TMEM60 TNF	16 interacting genes: APP ARL6IP5 C1GALT1 ERGIC3 EWSR1 FAM209A FCER1G FXYD3 LDLRAD1 LMNA PAGE1 PRKCA RNF5 SLC35A1 SYNPR TMEM179B
Entrez ID		8712	6505
HPRD ID		02240	00597
Ensembl ID		ENSG00000068985	ENSG00000106688
Uniprot IDs		O75459	P43005
PDB IDs		Not available	6S3Q 6X2L 6X2Z 6X3E 6X3F 7NSG 8CTC 8CTD 8CUA 8CUD 8CUI 8CUJ 8CV2 8CV3 9D66 9D67 9D68 9D69 9D6A
GO Terms Enriched among Interactors		Response To Fructose Identical Protein Binding Response To Xenobiotic Stimulus Transport Across Blood-brain Barrier Recycling Endosome Vascular Process In Circulatory System Distal Dendrite D-aspartate Transmembrane Transporter Activity Perisynaptic Space Circulatory System Process Response To Decreased Oxygen Levels Fructose Import Across Plasma Membrane Positive Regulation Of Immunoglobulin Mediated Immune Response Transferrin Receptor Activity Positive Regulation Of Immunoglobulin Production Osteoclast Differentiation Regulation Of Immunoglobulin Production Negative Regulation Of Bile Acid Secretion Positive Regulation Of Translational Initiation By Iron Positive Regulation Of Interleukin-33 Production Chronic Inflammatory Response To Antigenic Stimulus Response To Gram-negative Bacterium Positive Regulation Of Chronic Inflammatory Response To Antigenic Stimulus Negative Regulation Of L-glutamate Import Across Plasma Membrane Positive Regulation Of Fractalkine Production Negative Regulation Of Branching Involved In Lung Morphogenesis Positive Regulation Of Blood Microparticle Formation Response To Gold Nanoparticle Positive Regulation Of Vitamin D Biosynthetic Process Regulation Of RRNA Stability B-1a B Cell Differentiation Response To Oxygen Levels Cysteine Transmembrane Transport Cysteine Transmembrane Transporter Activity Cellular Response To Mercury Ion Leukocyte Differentiation Response To 3,3',5-triiodo-L-thyronine Positive Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell Positive Regulation Of Neutrophil Activation Response To Transition Metal Nanoparticle Diacylglycerol Diphosphate Phosphatase Activity Recycling Endosome Membrane Membrane Cysteine Transport Cellular Response To Ammonium Ion Cellular Response To Bisphenol A Regulation Of Heart Rate Cellular Response To Fructose Stimulus Intestinal Hexose Absorption Response To Retinoic Acid	None