PAGE1 and DDX49

Number of citations: 97 (PubMedID 33961781)
Data Source: BioGRID (two hybrid, affinity chromatography technology)

		PAGE1	DDX49
Name		PAGE family member 1	DEAD-box helicase 49
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	None	Nucleus Nucleoplasm Nucleolus
	Molecular Function	Protein Binding	Nucleotide Binding Nucleic Acid Binding RNA Binding RNA Helicase Activity Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity
	Biological Process	None	RRNA Processing Positive Regulation Of Cell Growth Regulation Of RRNA Stability
Pathways		None	rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol
GWAS		No GWAS studies recorded	Cerebrospinal fluid p-Tau181p:AB1-42 ratio ( 26252872 ) Cerebrospinal P-tau181p levels ( 26252872 )
Interacting Genes		12 interacting genes: CMTM7 DDX49 FAM9B MGST3 PLPP4 SLC1A1 SLC2A5 TFRC TMEM14B TMEM254 TMEM60 TNF	12 interacting genes: APP CEBPA HAP1 MIR1-2 MIR138-2 MIR140 MIR15A MIR199A1 MIR214 PAGE1 PSMB2 STX1A
Entrez ID		8712	54555
HPRD ID		02240	10864
Ensembl ID		ENSG00000068985	ENSG00000105671
Uniprot IDs		O75459	Q9Y6V7
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Response To Fructose Identical Protein Binding Response To Xenobiotic Stimulus Transport Across Blood-brain Barrier Recycling Endosome Vascular Process In Circulatory System Distal Dendrite D-aspartate Transmembrane Transporter Activity Perisynaptic Space Circulatory System Process Response To Decreased Oxygen Levels Fructose Import Across Plasma Membrane Positive Regulation Of Immunoglobulin Mediated Immune Response Transferrin Receptor Activity Positive Regulation Of Immunoglobulin Production Osteoclast Differentiation Regulation Of Immunoglobulin Production Negative Regulation Of Bile Acid Secretion Positive Regulation Of Translational Initiation By Iron Positive Regulation Of Interleukin-33 Production Chronic Inflammatory Response To Antigenic Stimulus Response To Gram-negative Bacterium Positive Regulation Of Chronic Inflammatory Response To Antigenic Stimulus Negative Regulation Of L-glutamate Import Across Plasma Membrane Positive Regulation Of Fractalkine Production Negative Regulation Of Branching Involved In Lung Morphogenesis Positive Regulation Of Blood Microparticle Formation Response To Gold Nanoparticle Positive Regulation Of Vitamin D Biosynthetic Process Regulation Of RRNA Stability B-1a B Cell Differentiation Response To Oxygen Levels Cysteine Transmembrane Transport Cysteine Transmembrane Transporter Activity Cellular Response To Mercury Ion Leukocyte Differentiation Response To 3,3',5-triiodo-L-thyronine Positive Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell Positive Regulation Of Neutrophil Activation Response To Transition Metal Nanoparticle Diacylglycerol Diphosphate Phosphatase Activity Recycling Endosome Membrane Membrane Cysteine Transport Cellular Response To Ammonium Ion Cellular Response To Bisphenol A Regulation Of Heart Rate Cellular Response To Fructose Stimulus Intestinal Hexose Absorption Response To Retinoic Acid	RISC Complex MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing Post-transcriptional Regulation Of Gene Expression MRNA Base-pairing Post-transcriptional Repressor Activity Negative Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Smooth Muscle Cell Migration MRNA 3'-UTR Binding Negative Regulation Of Gene Expression Negative Regulation Of Cell Population Proliferation Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Macromolecule Metabolic Process Regulation Of Amyloid Precursor Protein Catabolic Process Negative Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Metabolic Process Regulation Of Smooth Muscle Cell Migration Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Connective Tissue Replacement Negative Regulation Of Biosynthetic Process Regulation Of Chemokine Production Regulation Of Connective Tissue Replacement Negative Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Cell Migration Regulation Of BMP Signaling Pathway Negative Regulation Of Multicellular Organismal Process Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Cytokine Production Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Negative Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Positive Regulation Of Tissue Remodeling Positive Regulation Of Synaptic Transmission Positive Regulation Of Developmental Process Regulation Of Osteoblast Differentiation Myosin Binding Negative Regulation Of Amyloid-beta Formation Regulation Of Smooth Muscle Cell Proliferation Regulation Of Inflammatory Response Regulation Of Cytokine Production Regulation Of Defense Response Negative Regulation Of Amyloid Precursor Protein Catabolic Process Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of SMAD Protein Signal Transduction