S1PR4 and TNFSF14

Data Source: HiPPIP (Novel)

		S1PR4	TNFSF14
Name		sphingosine-1-phosphate receptor 4	TNF superfamily member 14
Structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Plasma Membrane Membrane Presynapse	Extracellular Region Extracellular Space Cytoplasm Plasma Membrane Membrane
	Molecular Function	G Protein-coupled Receptor Activity Protein Binding Lipid Binding Sphingosine-1-phosphate Receptor Activity	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding Identical Protein Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
	Biological Process	Sphingosine-1-phosphate Receptor Signaling Pathway Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway	Apoptotic Process Immune Response Cell Communication Signal Transduction Cell Surface Receptor Signaling Pathway T Cell Chemotaxis Positive Regulation Of T Cell Chemotaxis Signaling T Cell Costimulation T Cell Proliferation T Cell Activation T Cell Homeostasis Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Myoblast Differentiation Cellular Response To Mechanical Stimulus Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Myoblast Fusion Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		G alpha (i) signalling events Lysosphingolipid and LPA receptors	TNFR2 non-canonical NF-kB pathway TNFs bind their physiological receptors TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
Drugs		Fingolimod	None
GWAS		Asthma ( 31959851 ) Basophil percentage of granulocytes ( 27863252 ) Eosinophil count ( 27863252 32888494 ) Eosinophil percentage of granulocytes ( 27863252 ) Eosinophil percentage of white cells ( 27863252 32888494 ) Granulocyte count ( 27863252 ) Granulocyte percentage of myeloid white cells ( 27863252 ) High light scatter reticulocyte count ( 32888494 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Immature fraction of reticulocytes ( 32888494 ) Lymphocyte count ( 32888494 ) Lymphocyte percentage of white cells ( 27863252 ) Mean platelet volume ( 32888494 ) Monocyte count ( 32888494 27863252 ) Monocyte percentage of white cells ( 32888494 27863252 ) Myeloid white cell count ( 27863252 ) Neutrophil count ( 27863252 ) Neutrophil percentage of granulocytes ( 27863252 ) Neutrophil percentage of white cells ( 32888494 27863252 ) Plateletcrit ( 32888494 ) Reticulocyte fraction of red cells ( 32888494 ) Sum basophil neutrophil counts ( 27863252 ) Sum eosinophil basophil counts ( 27863252 ) Sum neutrophil eosinophil counts ( 27863252 ) White blood cell count ( 32888494 29403010 27863252 )	Blood protein levels ( 30072576 ) Blood protein levels in cardiovascular risk ( 28369058 ) Granulocyte percentage of myeloid white cells ( 27863252 ) Monocyte count ( 29403010 ) Monocyte percentage of white cells ( 27863252 ) Multiple sclerosis ( 21833088 24076602 31604244 )
Novel Interactors		1 novel interactors: TNFSF14	3 novel interactors: S1PR4 SLC38A3 TCF3
Interacting Genes		4 interacting genes: GEMIN4 GNA12 GNA13 GNAI1	22 interacting genes: ADAM33 ADIPOQ APP BMP10 CLDN11 CLDN19 CXCL9 JAGN1 LHFPL3 LTB LTBR MAL OLFM4 PLLP PTTG1IP SEC22A SEC23A SYS1 TMEM11 TNFRSF14 TNFRSF6B UPK2
Entrez ID		8698	8740
HPRD ID		04779	05157
Ensembl ID		ENSG00000125910	ENSG00000125735
Uniprot IDs		O95977	O43557
PDB IDs		2DCO	4EN0 4J6G 4KG8 4KGG 4KGQ 4RSU 7MSG
GO Terms Enriched among Interactors		Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding D5 Dopamine Receptor Binding Heterotrimeric G-protein Complex G Protein-coupled Receptor Binding G Protein Activity Rho-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway T Cell Migration Regulation Of Fibroblast Migration GTPase Activity Brush Border Membrane GTP Binding Lymphocyte Migration Rho Protein Signal Transduction Mononuclear Cell Migration Regulation Of Cell Shape G Protein-coupled Receptor Signaling Pathway D2 Dopamine Receptor Binding Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Relaxation Of Smooth Muscle G Protein-coupled Serotonin Receptor Binding Regulation Of Blood Pressure Adenylate Cyclase Inhibitor Activity Adenylate Cyclase Regulator Activity Regulation Of Cell Migration Leukocyte Migration Positive Regulation Of Protein Localization To Cell Cortex Regulation Of Cell Motility Regulation Of Cell Morphogenesis In Utero Embryonic Development Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Regulation Of Locomotion Small GTPase-mediated Signal Transduction Regulation Of Protein Localization To Cell Cortex Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway SMN Complex Gemini Of Cajal Bodies Cellular Response To Forskolin Regulation Of Relaxation Of Muscle T Cell Chemotaxis Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Positive Regulation Of T Cell Chemotaxis Regulation Of T Cell Chemotaxis Positive Regulation Of Myoblast Fusion Small Nuclear Ribonucleoprotein Complex Response To Forskolin SMN-Sm Protein Complex	Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Schmidt-Lanterman Incisure Structural Constituent Of Myelin Sheath Membrane Regulation Of Apoptotic Signaling Pathway Positive Regulation Of CAMP/PKA Signal Transduction Cytokine Activity Axon Ensheathment Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules