TNFSF14 and ADAM33

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		TNFSF14	ADAM33
Name		TNF superfamily member 14	ADAM metallopeptidase domain 33
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Plasma Membrane Membrane	Membrane
	Molecular Function	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding Identical Protein Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process	Metalloendopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Apoptotic Process Immune Response Cell Communication Signal Transduction Cell Surface Receptor Signaling Pathway T Cell Chemotaxis Positive Regulation Of T Cell Chemotaxis Signaling T Cell Costimulation T Cell Proliferation T Cell Activation T Cell Homeostasis Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Myoblast Differentiation Cellular Response To Mechanical Stimulus Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Myoblast Fusion Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Proteolysis
Pathways		TNFR2 non-canonical NF-kB pathway TNFs bind their physiological receptors TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	Regulation of CDH11 function
Diseases		None	Asthma
GWAS		Blood protein levels ( 30072576 ) Blood protein levels in cardiovascular risk ( 28369058 ) Granulocyte percentage of myeloid white cells ( 27863252 ) Monocyte count ( 29403010 ) Monocyte percentage of white cells ( 27863252 ) Multiple sclerosis ( 21833088 24076602 31604244 )	Night sleep phenotypes ( 27126917 ) Platelet distribution width ( 32888494 ) Reticulocyte count ( 32888494 ) White blood cell count ( 32888494 )
Novel Interactors		3 novel interactors: S1PR4 SLC38A3 TCF3	None recorded
Interacting Genes		22 interacting genes: ADAM33 ADIPOQ APP BMP10 CLDN11 CLDN19 CXCL9 JAGN1 LHFPL3 LTB LTBR MAL OLFM4 PLLP PTTG1IP SEC22A SEC23A SYS1 TMEM11 TNFRSF14 TNFRSF6B UPK2	33 interacting genes: AQP9 ASGR2 ATXN7 BTNL9 CD3E CLDN2 CLEC7A CREB3L1 CYB5R3 EPGN FCGR2A GGT6 HIBADH KIR3DL3 LMNA MUC1 NCR1 OPRM1 PLEKHO1 SEC11A SGCB SLC22A23 SLC30A2 SLC35E2A SLC4A1 SPINT1 STOML3 TMEM106C TMEM14B TMEM237 TNFSF14 UBQLN4 VMA21
Entrez ID		8740	80332
HPRD ID		05157	06173
Ensembl ID		ENSG00000125735	ENSG00000149451
Uniprot IDs		O43557	A2A2L3 Q9BZ11
PDB IDs		4EN0 4J6G 4KG8 4KGG 4KGQ 4RSU 7MSG	1R54 1R55
GO Terms Enriched among Interactors		Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Schmidt-Lanterman Incisure Structural Constituent Of Myelin Sheath Membrane Regulation Of Apoptotic Signaling Pathway Positive Regulation Of CAMP/PKA Signal Transduction Cytokine Activity Axon Ensheathment Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules	Membrane Plasma Membrane