TNFSF14 and TNFRSF6B

Number of citations of the paper that reports this interaction (PMID 11994433)
17

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		TNFSF14	TNFRSF6B
Gene Name		tumor necrosis factor (ligand) superfamily, member 14	tumor necrosis factor receptor superfamily, member 6b, decoy
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Cytoplasm Plasma Membrane Integral Component Of Membrane	Extracellular Space
	Molecular Function	Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process	Receptor Activity Protein Binding
	Biological Process	Apoptotic Process Immune Response Signal Transduction Release Of Cytoplasmic Sequestered NF-kappaB Positive Regulation Of T Cell Chemotaxis T Cell Costimulation T Cell Proliferation T Cell Activation T Cell Homeostasis Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Myoblast Differentiation Cellular Response To Mechanical Stimulus Positive Regulation Of Myoblast Fusion	Apoptotic Process Negative Regulation Of Apoptotic Process
Pathways
Drugs
Diseases
GWAS		Multiple sclerosis ( 21833088)	Glioma ( 22886559) Inflammatory bowel disease ( 18758464 23128233) Prostate cancer ( 23535732) Ulcerative colitis ( 21297633)
Protein-Protein Interactions		5 interactors: APP LTB LTBR TNFRSF14 TNFRSF6B	5 interactors: FASLG KRTAP10-3 KRTAP10-9 TNFSF14 TNFSF15
Entrez ID		8740	8771
HPRD ID		05157	04527
Ensembl ID		ENSG00000125735	ENSG00000243509
Uniprot IDs		O43557	O95407
PDB IDs		4EN0 4J6G 4KG8 4KGG 4KGQ	3K51 3MHD 3MI8 4J6G 4KGG 4KGQ
Enriched GO Terms of Interacting Partners?		Programmed Cell Death Cell Death Death Immune System Process Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Positive Regulation Of Cellular Metabolic Process Apoptotic Process Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cytokine Secretion Involved In Immune Response Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Protein Metabolic Process Axon Choice Point Recognition Immune Response Negative Regulation Of Alpha-beta T Cell Proliferation Regulation Of Phosphorylation Neuron Remodeling Positive Regulation Of Metabolic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cytokine Production Regulation Of Cytokine Secretion Involved In Immune Response Positive Regulation Of Interleukin-12 Biosynthetic Process Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Interleukin-12 Biosynthetic Process Positive Regulation Of T Cell Migration Lymph Node Development Cellular Copper Ion Homeostasis Response To External Stimulus Regulation Of T Cell Migration Regulation Of Cellular Ketone Metabolic Process Copper Ion Homeostasis Suckling Behavior Regulation Of Cytokine Production Negative Regulation Of Alpha-beta T Cell Activation Viral Process Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Myeloid Dendritic Cell Differentiation Myeloid Dendritic Cell Activation Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Regulation Of Lymphocyte Migration Regulation Of Protein Metabolic Process Mating Behavior Defense Response To Gram-negative Bacterium Endoplasmic Reticulum Calcium Ion Homeostasis Tumor Necrosis Factor-mediated Signaling Pathway Cell Activation	Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Regulation Of Proteolysis Positive Regulation Of Intracellular Signal Transduction Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Zymogen Activation Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Programmed Cell Death Positive Regulation Of Cysteine-type Endopeptidase Activity Cell Death Death Positive Regulation Of Endopeptidase Activity Positive Regulation Of Peptidase Activity Positive Regulation Of Signal Transduction Immune Response Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Apoptotic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Cell Death Protein Processing Endosomal Lumen Acidification Regulation Of Intracellular Signal Transduction Retinal Cell Programmed Cell Death Positive Regulation Of Proteolysis Release Of Cytoplasmic Sequestered NF-kappaB Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Transport Necroptotic Signaling Pathway Immune System Process Regulation Of Protein Metabolic Process Cellular Chloride Ion Homeostasis Inflammatory Cell Apoptotic Process Regulation Of Catalytic Activity Positive Regulation Of T Cell Chemotaxis Chloride Ion Homeostasis Positive Regulation Of Endothelial Cell Apoptotic Process Regulation Of Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Protein Transport T Cell Apoptotic Process Positive Regulation Of Myoblast Differentiation Positive Regulation Of T Cell Migration Positive Regulation Of Myoblast Fusion Regulation Of Signaling
Tagcloud ?		17f 28a 6ckine ccl13 ccl14 ccl16 ccl17 ccl18 ccl19 ccl21 ccl22 ccl23 ccl25 ccl26 ccl27 ccl28 ccl7 ccl8 ctack cxcl11 cxcl3 cxcl7 il18 lymphotactin mpif parc tarc teck xcl1	adjacent bioinformatics blotting clarified clinicopathological deregulation dnmt1 downregulated embedded fluorimetry formalin genesis hcc hepatocarcinogenesis hepb3 hepg2 intriguingly inverse mimic mir motility paraffin remarkably snu449 spectrophotometry underexpression vital
Tagcloud (Difference) ?		17f 28a 6ckine ccl13 ccl14 ccl16 ccl17 ccl18 ccl19 ccl21 ccl22 ccl23 ccl25 ccl26 ccl27 ccl28 ccl7 ccl8 ctack cxcl11 cxcl3 cxcl7 il18 lymphotactin mpif parc tarc teck xcl1	adjacent bioinformatics blotting clarified clinicopathological deregulation dnmt1 downregulated embedded fluorimetry formalin genesis hcc hepatocarcinogenesis hepb3 hepg2 intriguingly inverse mimic mir motility paraffin remarkably snu449 spectrophotometry underexpression vital
Tagcloud (Intersection) ?