EIF3H and LY6E

		EIF3H	LY6E
Description		eukaryotic translation initiation factor 3 subunit H	lymphocyte antigen 6 family member E
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 3 Complex Membrane Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Extracellular Exosome Eukaryotic Translation Initiation Factor 3 Complex, EIF3m	Extracellular Region Plasma Membrane Membrane Synapse Side Of Membrane
	Molecular Function	RNA Binding Translation Initiation Factor Activity Protein Binding Peptidase Activity Metallopeptidase Activity Metal-dependent Deubiquitinase Activity	Protein Binding Acetylcholine Receptor Inhibitor Activity Acetylcholine Receptor Binding
	Biological Process	Formation Of Cytoplasmic Translation Initiation Complex Cytoplasmic Translational Initiation Translation Translational Initiation Regulation Of Translational Initiation Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process	Cell Surface Receptor Signaling Pathway Host-mediated Suppression Of Symbiont Invasion Acetylcholine Receptor Signaling Pathway
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit	Post-translational modification: synthesis of GPI-anchored proteins
Drugs
Diseases
GWAS		Asthma ( 29273806) Body mass index ( 25673413) Colorectal cancer ( 21761138 30529582 29471430 18372905 26965516 26151821 25990418 24737748) Colorectal cancer or advanced adenoma ( 30510241) Corneal curvature ( 22969067) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Metabolite levels ( 23823483) Morning person ( 30696823) Ossification of the posterior longitudinal ligament of the spine ( 25064007) Right lateral prefrontal cortical growth ( 29682794) Systemic juvenile idiopathic arthritis ( 27927641) Waist circumference adjusted for body mass index ( 28552196 34021172)
Interacting Genes		14 interacting genes: ABI1 ABI2 ABI3 CCDC85B DISC1 EIF3G EIF3K NCK2 SNAI1 SORBS2 SORBS3 SPTBN1 UBC YAP1	6 interacting genes: CD247 FCGR2B MFSD6 TMEM140 TMEM19 TRARG1
Entrez ID		8667	4061
HPRD ID		04885	03227
Ensembl ID		ENSG00000147677	ENSG00000160932
Uniprot IDs		O15372 Q6IB98	Q16553
PDB IDs		3J8B 3J8C 6YBD 6ZMW 6ZON 6ZP4 6ZVJ 7A09 7QP6 7QP7 8OZ0 8PJ1 8PJ2 8PJ3 8PJ4 8PJ5 8PJ6 8PPL 8RG0 8XXN 9BLN
Enriched GO Terms of Interacting Partners?		Actin-based Cell Projection SCAR Complex Signaling Adaptor Activity Cytoskeletal Anchor Activity Postsynaptic Density Neuron Migration Lamellipodium Anchoring Junction Cytoplasm Regulation Of Cellular Component Organization Canonical Wnt Signaling Pathway Cell Migration Regulation Of Actin Filament Organization Structural Constituent Of Cytoskeleton Formation Of Cytoplasmic Translation Initiation Complex Eukaryotic Translation Initiation Factor 3 Complex Eukaryotic 48S Preinitiation Complex Eukaryotic 43S Preinitiation Complex Filopodium Tip Cytoskeleton Organization Cell Motility Regulation Of Actin Cytoskeleton Organization Regulation Of Postsynapse Organization Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Regulation Of Organelle Organization Cytoplasmic Translational Initiation Positive Regulation Of Supramolecular Fiber Organization Regulation Of Lamellipodium Assembly Positive Regulation Of Cytoskeleton Organization Regulation Of Dendritic Spine Morphogenesis Lamellipodium Organization Cell Surface Receptor Signaling Pathway Synapse Translation Initiation Factor Activity Regulation Of Lamellipodium Organization Peptidyl-tyrosine Phosphorylation Enterocyte Differentiation Regulation Of Cytoskeleton Organization Cytoskeleton Cytosol Regulation Of Cell Projection Assembly Negative Regulation Of Fat Cell Differentiation Mesoderm Development Actin Polymerization Or Depolymerization Actin Filament Organization Wnt Signaling Pathway Negative Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Central Nervous System Formation Cell Projection Morphogenesis	IgG Binding
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