PDE5A and PRKG1

Number of citations of the paper that reports this interaction (PubMedID 2168396)
0

Data Source:
HPRD (in vitro)

		PDE5A	PRKG1
Description		phosphodiesterase 5A	protein kinase cGMP-dependent 1
Image
GO Annotations	Cellular Component	Cytosol	Acrosomal Vesicle Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Sarcolemma
	Molecular Function	Nucleotide Binding Catalytic Activity 3',5'-cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-AMP Phosphodiesterase Activity Protein Binding Phosphoric Diester Hydrolase Activity Hydrolase Activity CGMP Binding Metal Ion Binding 3',5'-cyclic-GMP Phosphodiesterase Activity	Nucleotide Binding Catalytic Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity CGMP-dependent Protein Kinase Activity Calcium Channel Regulator Activity Protein Binding ATP Binding Kinase Activity Transferase Activity CGMP Binding Identical Protein Binding Mitogen-activated Protein Kinase P38 Binding Protein Serine Kinase Activity
	Biological Process	Signal Transduction CGMP Catabolic Process Negative Regulation Of CAMP/PKA Signal Transduction	Neuron Migration Protein Phosphorylation Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Spermatid Development Heart Development Negative Regulation Of Inositol Phosphate Biosynthetic Process Negative Regulation Of Glutamate Secretion Negative Regulation Of Smooth Muscle Cell Migration Dendrite Development CGMP-mediated Signaling Cerebellum Development Actin Cytoskeleton Organization Forebrain Development Vasodilation Positive Regulation Of Circadian Rhythm Regulation Of GTPase Activity Regulation Of Vascular Permeability Negative Regulation Of Smooth Muscle Contraction Collateral Sprouting Relaxation Of Vascular Associated Smooth Muscle Cell Growth Involved In Cardiac Muscle Cell Development Negative Regulation Of Platelet Aggregation Bone Growth Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration Regulation Of Testosterone Biosynthetic Process
Pathways		cGMP effects Smooth Muscle Contraction RHOBTB1 GTPase cycle	Ca2+ pathway
Drugs		Caffeine Caffeine Sildenafil Theophylline Tadalafil Vardenafil Dipyridamole Papaverine Guanosine-5'-Monophosphate gamma-Glutamyl[S-(2-iodobenzyl)cysteinyl]glycine OSI-461 Avanafil Exisulind Udenafil 3-isobutyl-1-methyl-7H-xanthine 5-ethoxy-4-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)thiophene-2-sulfonamide Trapidil Fostamatinib
Diseases
GWAS		A body shape index ( 34021172) Coronary artery disease ( 32469254) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Diastolic blood pressure ( 27841878 28135244) Height ( 28552196) Offspring birth weight ( 31043758) Platelet count ( 27863252) Plateletcrit ( 27863252) Refractive error ( 32231278) Systolic blood pressure ( 27841878) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)	3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Adult body size ( 32376654) Alcohol misuse (trauma interaction) ( 28265120) Anti-chlamydia trachomatis IgG seropositivity ( 29967566) Appendicular lean mass ( 33097823) Arthritis (juvenile idiopathic) ( 34101054) Asthma ( 21907864) Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 28552196) Colorectal cancer or advanced adenoma ( 30510241) Coronary artery disease ( 29212778) Eosinophilic esophagitis ( 34506852) Gait rhythm ( 26219847) HDL cholesterol levels in HIV infection ( 33109212) Height ( 28552196 31562340) Interferon alpha levels in systemic lupus erythematosus ( 25338677) LDL cholesterol levels in HIV infection ( 33109212) Logical memory (delayed recall) in normal cognition ( 29274321) Loneliness (multivariate analysis) ( 27629369) Mammographic density (non-dense area) ( 25342443) Mitochondrial DNA copy number ( 30704525) Obesity-related traits ( 23251661) Rosacea symptom severity ( 29771307) Schizophrenia ( 30285260) Stroke ( 32693751) Systolic blood pressure ( 32902719) Triglyceride levels x loop diuretics use interaction ( 31806883)
Interacting Genes		3 interacting genes: CASP3 PRKG1 SPG21	40 interacting genes: ANXA7 AR ARHGEF15 CFTR CREB1 CRIP2 FAM124A FHOD1 GABRR1 GKAP1 GTF2I HDAC1 IRAG1 ITPR1 LASP1 LMO2 MEOX2 NPR1 PDE5A PLCB3 PPP1R12A PPP1R12B PPP1R17 PRKCA RAF1 RBAK RGS2 RYR1 SELL SEPTIN3 SF1 SPP1 TNNT1 TRIM39-RPP21 TRIM54 TRPC3 VASP VHL WDR77 ZNF646
Entrez ID		8654	5592
HPRD ID		04497	08910
Ensembl ID		ENSG00000138735	ENSG00000185532
Uniprot IDs		G5E9C5 O76074	B1ALS0 Q13976
PDB IDs		1RKP 1T9R 1T9S 1TBF 1UDT 1UDU 1UHO 1XOZ 1XP0 2CHM 2H40 2H42 2H44 2XSS 3B2R 3BJC 3HC8 3HDZ 3JWQ 3JWR 3LFV 3MF0 3SHY 3SHZ 3SIE 3TGE 3TGG 4G2W 4G2Y 4I9Z 4IA0 4MD6 4OEW 4OEX 5JO3 5ZZ2 6ACB 6IWI 6L6E 6VBI 7FAQ 7FAR 8W4S 8W4T 8WKF 8WKG 8XWW	1ZXA 3NMD 3OCP 3OD0 3OGJ 4KU7 4KU8 4QX5 4QXK 4R4L 4R4M 4Z07 5J48 5JAX 5JD7 5L0N 6BDL 6BG2 6C0T 7LV3 7MBJ 7SSB 7T4T 7T4U 7T4V 7T4W
Enriched GO Terms of Interacting Partners?		Collateral Sprouting Developmental Cell Growth Developmental Growth Involved In Morphogenesis Heart Development Negative Regulation Of Cell Activation Anterior Neural Tube Closure Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Cellular Response To Staurosporine Luteolysis Glial Cell Apoptotic Process Negative Regulation Of Cell-cell Adhesion Phospholipase A2 Activator Activity System Process CGMP-dependent Protein Kinase Activity Negative Regulation Of Inositol Phosphate Biosynthetic Process Negative Regulation Of Glutamate Secretion Response To Anesthetic Death-inducing Signaling Complex Negative Regulation Of Cell Adhesion Mitogen-activated Protein Kinase P38 Binding Regulation Of Testosterone Biosynthetic Process Relaxation Of Smooth Muscle Relaxation Of Vascular Associated Smooth Muscle Positive Regulation Of Pyroptotic Inflammatory Response Developmental Growth Cell Growth Involved In Cardiac Muscle Cell Development CD4 Receptor Binding Regulation Of Synaptic Vesicle Cycle Neuron Projection Development Response To Cobalt Ion Interleukin-18-mediated Signaling Pathway Fibroblast Apoptotic Process Regulation Of Cell-cell Adhesion Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Activated T Cell Proliferation Negative Regulation Of Amino Acid Transport CGMP Binding Negative Regulation Of Homotypic Cell-cell Adhesion Negative Regulation Of Smooth Muscle Contraction Negative Regulation Of Platelet Aggregation Negative Regulation Of B Cell Proliferation Positive Regulation Of Amyloid-beta Formation Death Receptor Binding Aspartic-type Endopeptidase Activity Axonal Fasciculation Neuron Projection Fasciculation Protein Poly-ADP-ribosylation Positive Regulation Of Circadian Rhythm	Response To Ketone Positive Regulation Of Hormone Secretion Regulation Of Muscle System Process Negative Regulation Of Muscle Contraction Enzyme Binding Regulation Of System Process CGMP-mediated Signaling RNA Polymerase II-specific DNA-binding Transcription Factor Binding Phosphatase Regulator Activity Myosin Phosphatase Regulator Activity Relaxation Of Vascular Associated Smooth Muscle Positive Regulation Of Secretion Cellular Response To Testosterone Stimulus Relaxation Of Smooth Muscle Intracellular Signaling Cassette Epithelial Cell Differentiation Involved In Prostate Gland Development Intracellularly Gated Calcium Channel Activity Platelet Dense Tubular Network Membrane Response To Phorbol 13-acetate 12-myristate Response To Alcohol Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Anatomical Structure Morphogenesis Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Regulation Of Hormone Secretion Response To Purine-containing Compound Epithelial Fluid Transport Regulation Of Smooth Muscle Cell Proliferation Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Cytosolic Calcium Ion Concentration Protein Homotetramerization Release Of Sequestered Calcium Ion Into Cytosol By Endoplasmic Reticulum Negative Regulation Of Sequestering Of Calcium Ion Inositol 1,4,5 Trisphosphate Binding Z Disc Positive Regulation Of Bone Resorption Negative Regulation Of Smooth Muscle Contraction Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Cellular Response To Forskolin Sarcoplasmic Reticulum A Band Monoatomic Ion Channel Activity Positive Regulation Of RNA Metabolic Process Positive Regulation Of Secretion By Cell Regulation Of Cardiac Muscle Hypertrophy Response To Forskolin Regulation Of Muscle Contraction Regulation Of Developmental Process CGMP Metabolic Process Molecular Adaptor Activity
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