PDE5A and PRKG1

Number of citations of the paper that reports this interaction (PMID 2168396)
15

Data Source:
HPRD (in vitro)

		PDE5A	PRKG1
Gene Name		phosphodiesterase 5A, cGMP-specific	protein kinase, cGMP-dependent, type I
Image
Gene Ontology Annotations	Cellular Component	Cellular_component Cytosol	Cytoplasm Golgi Apparatus Cytosol Plasma Membrane
	Molecular Function	3',5'-cyclic-nucleotide Phosphodiesterase Activity CGMP Binding Metal Ion Binding 3',5'-cyclic-GMP Phosphodiesterase Activity	CGMP-dependent Protein Kinase Activity Calcium Channel Regulator Activity Protein Binding ATP Binding CGMP Binding
	Biological Process	Signal Transduction Blood Coagulation Positive Regulation Of Cardiac Muscle Hypertrophy Regulation Of CGMP Metabolic Process Negative Regulation Of T Cell Proliferation Positive Regulation Of MAP Kinase Activity CGMP Catabolic Process Negative Regulation Of Cardiac Muscle Contraction Relaxation Of Cardiac Muscle Positive Regulation Of Oocyte Development	Neuron Migration Protein Phosphorylation Signal Transduction Blood Coagulation Dendrite Development CGMP-mediated Signaling Actin Cytoskeleton Organization Forebrain Development Regulation Of GTPase Activity Relaxation Of Vascular Smooth Muscle Negative Regulation Of Platelet Aggregation
Pathways		Platelet homeostasis Nitric oxide stimulates guanylate cyclase cGMP effects	Ca2+ pathway Signaling by Wnt beta-catenin independent WNT signaling
Drugs		Sildenafil Theophylline Pentoxifylline Tadalafil Vardenafil Dipyridamole Guanosine-5\'-Monophosphate Gamma-Glutamyl[S-(2-Iodobenzyl)Cysteinyl]Glycine Citric Acid Avanafil Udenafil 3-ISOBUTYL-1-METHYLXANTHINE 5-ethoxy-4-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)thiophene-2-sulfonamide
Diseases
GWAS			Asthma ( 21907864) Obesity-related traits ( 23251661)
Protein-Protein Interactions		2 interactors: CASP3 PRKG1	34 interactors: ANXA7 CFTR CREB1 CRIP2 FAM124A FHOD1 GABRR1 GKAP1 GTF2I HDAC1 ITPR1 LASP1 LMO2 MRVI1 NPR1 PDE5A PLCB3 PPP1R12A PPP1R12B PPP1R17 PRKCA RAF1 RGS2 RYR1 SELL SEPT3 SF1 SPP1 TBXA2R TNNT1 TRIM39-RPP21 TRPC3 VASP ZNF646
Entrez ID		8654	5592
HPRD ID		04497	08910
Ensembl ID		ENSG00000138735	ENSG00000185532
Uniprot IDs		G5E9C5 O76074	Q13976
PDB IDs		1RKP 1T9R 1T9S 1TBF 1UDT 1UDU 1UHO 1XOZ 1XP0 2CHM 2H40 2H42 2H44 2XSS 3B2R 3BJC 3HC8 3HDZ 3JWQ 3JWR 3LFV 3MF0 3SHY 3SHZ 3SIE 3TGE 3TGG 3TSE 3TSF 4G2W 4G2Y	1ZXA 3NMD 3OCP 3OD0 3OGJ
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Homotypic Cell-cell Adhesion Negative Regulation Of Cell-cell Adhesion Negative Regulation Of Cell Adhesion Regulation Of Cell-cell Adhesion Regulation Of Cell Activation Glial Cell Apoptotic Process Regulation Of Apoptotic DNA Fragmentation Regulation Of Cell Adhesion Relaxation Of Vascular Smooth Muscle CGMP-mediated Signaling Relaxation Of Smooth Muscle Negative Regulation Of Platelet Aggregation Response To Wounding Negative Regulation Of Activated T Cell Proliferation Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Negative Regulation Of Smooth Muscle Contraction Regulation Of Platelet Aggregation Negative Regulation Of B Cell Proliferation Negative Regulation Of Platelet Activation Apoptotic DNA Fragmentation Negative Regulation Of Muscle Contraction Platelet Formation Platelet Morphogenesis Relaxation Of Muscle Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Regulation Of Execution Phase Of Apoptosis Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Neuron Differentiation Hippo Signaling Release Of Cytochrome C From Mitochondria Cyclic-nucleotide-mediated Signaling Apoptotic Nuclear Changes Regulation Of Platelet Activation Vasodilation Regulation Of Activated T Cell Proliferation B Cell Homeostasis T Cell Homeostasis Negative Regulation Of B Cell Activation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Generation Of Neurons Regulation Of Smooth Muscle Contraction Negative Regulation Of Blood Coagulation Neuron Apoptotic Process Regulation Of B Cell Proliferation Negative Regulation Of Coagulation Neurogenesis Positive Regulation Of Neuron Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Negative Regulation Of T Cell Proliferation	Regulation Of Body Fluid Levels Hemostasis Regulation Of Muscle Contraction Blood Coagulation Negative Regulation Of Muscle Contraction Regulation Of Cardiac Muscle Hypertrophy Wound Healing Response To Wounding Cellular Response To Stimulus Response To Stimulus Positive Regulation Of Cardiac Muscle Hypertrophy Regulation Of Cellular Process Response To Organic Substance Cellular Cation Homeostasis Cellular Ion Homeostasis Cellular Calcium Ion Homeostasis Relaxation Of Muscle Calcium Ion Homeostasis Regulation Of Blood Vessel Size Regulation Of Tube Size Blood Circulation Signal Transduction Cellular Chemical Homeostasis Regulation Of Phospholipase Activity Platelet Activation Ion Homeostasis Neurotrophin TRK Receptor Signaling Pathway Vasodilation Neurotrophin Signaling Pathway Cellular Metal Ion Homeostasis Signaling Cell Communication Muscle System Process Cellular Homeostasis Metal Ion Homeostasis Relaxation Of Vascular Smooth Muscle Activation Of Phospholipase C Activity Positive Regulation Of Metabolic Process Regulation Of Smooth Muscle Contraction Relaxation Of Smooth Muscle Positive Regulation Of Phospholipase C Activity Regulation Of Ion Homeostasis Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Response To Purine-containing Compound Cytosolic Calcium Ion Homeostasis Chemical Homeostasis Cellular Response To Fibroblast Growth Factor Stimulus Relaxation Of Cardiac Muscle
Tagcloud ?		4q27 8q24 aberration breakpoint breakpoints cgmp conspicuous deregulated deregulating guanosine hl hodgkin homeobox infiltrated karyotyping monophosphate phosphodiesterase q24 q27 rational reed repress rq shortlisted sildenafil stat1 sternberg therein zhx2	1n9c acsl3 agpat3 bovinesnp50 bta1 c10 c12 c14 c18 chuk dgat1 echs1 ehhadh groundwork htr1b lipj lipk minpp1 mogat1 nfkb2 osbpl8 oxct1 plink scd1 sfa sorbs1 ufa underling unraveling
Tagcloud (Difference) ?		4q27 8q24 aberration breakpoint breakpoints cgmp conspicuous deregulated deregulating guanosine hl hodgkin homeobox infiltrated karyotyping monophosphate phosphodiesterase q24 q27 rational reed repress rq shortlisted sildenafil stat1 sternberg therein zhx2	1n9c acsl3 agpat3 bovinesnp50 bta1 c10 c12 c14 c18 chuk dgat1 echs1 ehhadh groundwork htr1b lipj lipk minpp1 mogat1 nfkb2 osbpl8 oxct1 plink scd1 sfa sorbs1 ufa underling unraveling
Tagcloud (Intersection) ?