PDE5A

Description		phosphodiesterase 5A
Image
GO Annotations	Cellular Component	Cytosol
	Molecular Function	Nucleotide Binding Catalytic Activity 3',5'-cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-AMP Phosphodiesterase Activity Protein Binding Phosphoric Diester Hydrolase Activity Hydrolase Activity CGMP Binding Metal Ion Binding 3',5'-cyclic-GMP Phosphodiesterase Activity
	Biological Process	Signal Transduction CGMP Catabolic Process Negative Regulation Of CAMP/PKA Signal Transduction
Pathways		cGMP effects Smooth Muscle Contraction RHOBTB1 GTPase cycle
Drugs		Caffeine Caffeine Sildenafil Theophylline Tadalafil Vardenafil Dipyridamole Papaverine Guanosine-5'-Monophosphate gamma-Glutamyl[S-(2-iodobenzyl)cysteinyl]glycine OSI-461 Avanafil Exisulind Udenafil 3-isobutyl-1-methyl-7H-xanthine 5-ethoxy-4-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)thiophene-2-sulfonamide Trapidil Fostamatinib
Diseases
GWAS		A body shape index ( 34021172) Coronary artery disease ( 32469254) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Diastolic blood pressure ( 27841878 28135244) Height ( 28552196) Offspring birth weight ( 31043758) Platelet count ( 27863252) Plateletcrit ( 27863252) Refractive error ( 32231278) Systolic blood pressure ( 27841878) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
Interacting Genes		3 interacting genes: CASP3 PRKG1 SPG21
Entrez ID		8654
HPRD ID		04497
Ensembl ID		ENSG00000138735
Uniprot IDs		G5E9C5 O76074
PDB IDs		1RKP 1T9R 1T9S 1TBF 1UDT 1UDU 1UHO 1XOZ 1XP0 2CHM 2H40 2H42 2H44 2XSS 3B2R 3BJC 3HC8 3HDZ 3JWQ 3JWR 3LFV 3MF0 3SHY 3SHZ 3SIE 3TGE 3TGG 4G2W 4G2Y 4I9Z 4IA0 4MD6 4OEW 4OEX 5JO3 5ZZ2 6ACB 6IWI 6L6E 6VBI 7FAQ 7FAR 8W4S 8W4T 8WKF 8WKG 8XWW
Enriched GO Terms of Interacting Partners?		Collateral Sprouting Developmental Cell Growth Developmental Growth Involved In Morphogenesis Heart Development Negative Regulation Of Cell Activation Anterior Neural Tube Closure Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Cellular Response To Staurosporine Luteolysis Glial Cell Apoptotic Process Negative Regulation Of Cell-cell Adhesion Phospholipase A2 Activator Activity System Process CGMP-dependent Protein Kinase Activity Negative Regulation Of Inositol Phosphate Biosynthetic Process Negative Regulation Of Glutamate Secretion Response To Anesthetic Death-inducing Signaling Complex Negative Regulation Of Cell Adhesion Mitogen-activated Protein Kinase P38 Binding Regulation Of Testosterone Biosynthetic Process Relaxation Of Smooth Muscle Relaxation Of Vascular Associated Smooth Muscle Positive Regulation Of Pyroptotic Inflammatory Response Developmental Growth Cell Growth Involved In Cardiac Muscle Cell Development CD4 Receptor Binding Regulation Of Synaptic Vesicle Cycle Neuron Projection Development Response To Cobalt Ion Interleukin-18-mediated Signaling Pathway Fibroblast Apoptotic Process Regulation Of Cell-cell Adhesion Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Activated T Cell Proliferation Negative Regulation Of Amino Acid Transport CGMP Binding Negative Regulation Of Homotypic Cell-cell Adhesion Negative Regulation Of Smooth Muscle Contraction Negative Regulation Of Platelet Aggregation Negative Regulation Of B Cell Proliferation Positive Regulation Of Amyloid-beta Formation Death Receptor Binding Aspartic-type Endopeptidase Activity Axonal Fasciculation Neuron Projection Fasciculation Protein Poly-ADP-ribosylation Positive Regulation Of Circadian Rhythm
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