SSNA1 and SPAST

Number of citations of the paper that reports this interaction (PMID 15269182)
26

Data Source:
HPRD (in vivo, two hybrid)

		SSNA1	SPAST
Gene Name		Sjogren syndrome nuclear autoantigen 1	spastin
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Centrosome Cytosol Ciliary Basal Body	Nucleus Cytoplasm Endosome Endoplasmic Reticulum Centrosome Spindle Microtubule Microtubule Cytoskeleton Integral Component Of Membrane Midbody Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Identical Protein Binding	Protein Binding ATP Binding Microtubule Binding Microtubule-severing ATPase Activity Alpha-tubulin Binding Beta-tubulin Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Organelle Organization Intraciliary Transport Ciliary Receptor Clustering Involved In Smoothened Signaling Pathway	Microtubule Bundle Formation ER To Golgi Vesicle-mediated Transport Cytokinesis, Completion Of Separation Axonogenesis Metabolic Process Positive Regulation Of Microtubule Depolymerization Cytoplasmic Microtubule Organization Protein Hexamerization Microtubule Severing Protein Homooligomerization
Pathways		Organelle biogenesis and maintenance Loss of proteins required for interphase microtubule organizationÂ from the centrosome Loss of Nlp from mitotic centrosomes G2/M Transition Assembly of the primary cilium Centrosome maturation Regulation of PLK1 Activity at G2/M Transition Mitotic G2-G2/M phases Anchoring of the basal body to the plasma membrane Recruitment of mitotic centrosome proteins and complexes Cell Cycle, Mitotic
Drugs
Diseases
GWAS
Protein-Protein Interactions		8 interactors: EHHADH GOPC LNX1 SDCBP SPAST TBC1D7 TCEANC TXN2	4 interactors: CHMP1B IST1 RTN1 SSNA1
Entrez ID		8636	6683
HPRD ID		10251	05044
Ensembl ID		ENSG00000176101	ENSG00000021574
Uniprot IDs		O43805	E5KRP5 E5KRP6 Q9UBP0
PDB IDs			3EAB 3VFD
Enriched GO Terms of Interacting Partners?		Protein Homooligomerization Protein Oligomerization Cytoplasmic Sequestering Of CFTR Protein ER To Golgi Vesicle-mediated Transport Cytokinesis, Completion Of Separation Negative Regulation Of Cilium Assembly Positive Regulation Of Extracellular Vesicular Exosome Assembly Positive Regulation Of Microtubule Depolymerization Regulation Of Extracellular Vesicular Exosome Assembly Cellular Component Assembly Negative Regulation Of Golgi To Plasma Membrane Protein Transport Regulation Of Cellular Component Organization Mitotic Cytokinetic Process Regulation Of Organelle Organization Protein Hexamerization Regulation Of Golgi To Plasma Membrane Protein Transport Golgi Vesicle Transport Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Protein Complex Assembly Substrate-dependent Cell Migration, Cell Extension Microtubule Severing Negative Regulation Of Establishment Of Protein Localization To Plasma Membrane	Cytokinesis Viral Capsid Secondary Envelopment Cell Cycle Process Viral Release From Host Cell Cell Cycle Ciliary Receptor Clustering Involved In Smoothened Signaling Pathway Abscission Positive Regulation Of Collateral Sprouting Regulation Of Mitotic Spindle Assembly Regulation Of Spindle Assembly Cell Division Protein Localization Regulation Of Mitotic Spindle Organization Cell Separation After Cytokinesis Mitotic Metaphase Plate Congression Mitotic Cell Cycle Process Metaphase Plate Congression Mitotic Cell Cycle Intraciliary Transport Regulation Of Centrosome Duplication Establishment Of Chromosome Localization Regulation Of Centrosome Cycle Receptor Clustering
Tagcloud ?		auto autoantigen axon axonopathy branching cardinal centrioles centrosomes corticospinal cytokinesis extremity hsp hsps localizing na14 outgrowth paraplegias postulate severing severs sjogren spastic spasticity spastin spatially spg1 spg4 temporally tubulation	accounts autosomal backgroundhereditary cassette conclusionsspg4 determinants earlier families hsp hsps inverted limbs mark mark0 mark18 mark19 methodsa paraplegias preservation question resultsmutations spg31 spg3a spg4 taiwanese weakness
Tagcloud (Difference) ?		auto autoantigen axon axonopathy branching cardinal centrioles centrosomes corticospinal cytokinesis extremity localizing na14 outgrowth postulate severing severs sjogren spatially spg1 temporally tubulation	accounts autosomal backgroundhereditary cassette conclusionsspg4 determinants earlier families inverted limbs mark mark0 mark18 mark19 methodsa preservation question resultsmutations spg31 spg3a taiwanese weakness
Tagcloud (Intersection) ?		hsp hsps paraplegias spastic spasticity spastin spg4