SPAST and SSNA1

Number of citations of the paper that reports this interaction (PMID 15269182)
26

Data Source:
HPRD (in vivo, two hybrid)

		SPAST	SSNA1
Gene Name		spastin	Sjogren syndrome nuclear autoantigen 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Endosome Endoplasmic Reticulum Centrosome Spindle Microtubule Microtubule Cytoskeleton Integral Component Of Membrane Midbody Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Nucleus Centrosome Cytosol Ciliary Basal Body
	Molecular Function	Protein Binding ATP Binding Microtubule Binding Microtubule-severing ATPase Activity Alpha-tubulin Binding Beta-tubulin Binding	Identical Protein Binding
	Biological Process	Microtubule Bundle Formation ER To Golgi Vesicle-mediated Transport Cytokinesis, Completion Of Separation Axonogenesis Metabolic Process Positive Regulation Of Microtubule Depolymerization Cytoplasmic Microtubule Organization Protein Hexamerization Microtubule Severing Protein Homooligomerization	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Organelle Organization Intraciliary Transport Ciliary Receptor Clustering Involved In Smoothened Signaling Pathway
Pathways			Organelle biogenesis and maintenance Loss of proteins required for interphase microtubule organizationÂ from the centrosome Loss of Nlp from mitotic centrosomes G2/M Transition Assembly of the primary cilium Centrosome maturation Regulation of PLK1 Activity at G2/M Transition Mitotic G2-G2/M phases Anchoring of the basal body to the plasma membrane Recruitment of mitotic centrosome proteins and complexes Cell Cycle, Mitotic
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: CHMP1B IST1 RTN1 SSNA1	8 interactors: EHHADH GOPC LNX1 SDCBP SPAST TBC1D7 TCEANC TXN2
Entrez ID		6683	8636
HPRD ID		05044	10251
Ensembl ID		ENSG00000021574	ENSG00000176101
Uniprot IDs		E5KRP5 E5KRP6 Q9UBP0	O43805
PDB IDs		3EAB 3VFD
Enriched GO Terms of Interacting Partners?		Cytokinesis Viral Capsid Secondary Envelopment Cell Cycle Process Viral Release From Host Cell Cell Cycle Ciliary Receptor Clustering Involved In Smoothened Signaling Pathway Abscission Positive Regulation Of Collateral Sprouting Regulation Of Mitotic Spindle Assembly Regulation Of Spindle Assembly Cell Division Protein Localization Regulation Of Mitotic Spindle Organization Cell Separation After Cytokinesis Mitotic Metaphase Plate Congression Mitotic Cell Cycle Process Metaphase Plate Congression Mitotic Cell Cycle Intraciliary Transport Regulation Of Centrosome Duplication Establishment Of Chromosome Localization Regulation Of Centrosome Cycle Receptor Clustering	Protein Homooligomerization Protein Oligomerization Cytoplasmic Sequestering Of CFTR Protein ER To Golgi Vesicle-mediated Transport Cytokinesis, Completion Of Separation Negative Regulation Of Cilium Assembly Positive Regulation Of Extracellular Vesicular Exosome Assembly Positive Regulation Of Microtubule Depolymerization Regulation Of Extracellular Vesicular Exosome Assembly Cellular Component Assembly Negative Regulation Of Golgi To Plasma Membrane Protein Transport Regulation Of Cellular Component Organization Mitotic Cytokinetic Process Regulation Of Organelle Organization Protein Hexamerization Regulation Of Golgi To Plasma Membrane Protein Transport Golgi Vesicle Transport Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Protein Complex Assembly Substrate-dependent Cell Migration, Cell Extension Microtubule Severing Negative Regulation Of Establishment Of Protein Localization To Plasma Membrane
Tagcloud ?		accounts autosomal backgroundhereditary cassette conclusionsspg4 determinants earlier families hsp hsps inverted limbs mark mark0 mark18 mark19 methodsa paraplegias preservation question resultsmutations spg31 spg3a spg4 taiwanese weakness	auto autoantigen axon axonopathy branching cardinal centrioles centrosomes corticospinal cytokinesis extremity hsp hsps localizing na14 outgrowth paraplegias postulate severing severs sjogren spastic spasticity spastin spatially spg1 spg4 temporally tubulation
Tagcloud (Difference) ?		accounts autosomal backgroundhereditary cassette conclusionsspg4 determinants earlier families inverted limbs mark mark0 mark18 mark19 methodsa preservation question resultsmutations spg31 spg3a taiwanese weakness	auto autoantigen axon axonopathy branching cardinal centrioles centrosomes corticospinal cytokinesis extremity localizing na14 outgrowth postulate severing severs sjogren spatially spg1 temporally tubulation
Tagcloud (Intersection) ?		hsp hsps paraplegias spastic spasticity spastin spg4