SPAST and SSNA1

Number of citations of the paper that reports this interaction (PubMedID 15269182)
0

Data Source:
HPRD (two hybrid, in vivo)

		SPAST	SSNA1
Description		spastin	SS nuclear autoantigen 1
Image			No pdb structure
GO Annotations	Cellular Component	Spindle Pole Nucleus Nucleoplasm Cytoplasm Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Droplet Centrosome Spindle Cytosol Cytoskeleton Microtubule Microtubule Cytoskeleton Membrane Axon Midbody Cytoplasmic Vesicle Nuclear Membrane Cell Projection Perinuclear Region Of Cytoplasm Extracellular Exosome Endoplasmic Reticulum Tubular Network Axon Cytoplasm	Nucleus Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Plasma Membrane Cilium Axoneme Axon Midbody Motile Cilium Ciliary Basal Body Cell Projection Supramolecular Fiber
	Molecular Function	Nucleotide Binding Catalytic Activity Protein Binding ATP Binding Microtubule Binding Microtubule Severing ATPase Activity Isomerase Activity ATP Hydrolysis Activity Alpha-tubulin Binding Protein-containing Complex Binding Beta-tubulin Binding	Protein Binding Microtubule Binding Identical Protein Binding
	Biological Process	Mitotic Cytokinesis Microtubule Bundle Formation Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Mitotic Nuclear Membrane Reassembly Nervous System Development Axonogenesis Anterograde Axonal Transport Exit From Mitosis Axonal Transport Of Mitochondrion Central Nervous System Neuron Axonogenesis Cell Differentiation Positive Regulation Of Microtubule Depolymerization Nuclear Membrane Reassembly Positive Regulation Of Cytokinesis Cytokinetic Process Protein Hexamerization Microtubule Severing Mitotic Spindle Disassembly Protein Homooligomerization Cell Division Cytoskeleton-dependent Cytokinesis Membrane Fission	Microtubule Cytoskeleton Organization Microtubule Nucleation Nervous System Development Axonogenesis Intraciliary Transport Receptor Clustering Axon Extension Cell Division Axon Arborization
Pathways		Sealing of the nuclear envelope (NE) by ESCRT-III	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases		Hereditary spastic paraplegia (SPG)
GWAS		Apolipoprotein A1 levels ( 32203549) Bisphosphonate-associated atypical femoral fracture ( 31006051) Inflammatory biomarkers ( 24182552) Interleukin-18 levels ( 31584380) Male-pattern baldness ( 28196072)
Interacting Genes		11 interacting genes: CEBPA CHMP1B CSNK2A1 DCAF8 FBXL17 IST1 OGT RIPK4 RTN1 SSNA1 USP20	13 interacting genes: CDC37 EHHADH FXR1 LNX1 NTAQ1 PICK1 PSMC5 RNF4 SDCBP SPAST TBC1D7 TCEANC TXN2
Entrez ID		6683	8636
HPRD ID		05044	10251
Ensembl ID		ENSG00000021574	ENSG00000176101
Uniprot IDs		A0A2R8Y4I8 A0A2R8YFW8 A0A2U3TZR0 E5KRP5 E5KRP6 Q9UBP0	O43805
PDB IDs		3EAB 3VFD 5Z6Q 5Z6R 6PEK 6PEN 7S7J
Enriched GO Terms of Interacting Partners?		MIT Domain Binding ESCRT III Complex Disassembly ESCRT Complex Disassembly Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteolysis Sin3-type Complex Midbody Abscission Regulation Of Ubiquitin-dependent Protein Catabolic Process Midbody Mitotic Cytokinetic Process Multivesicular Body Organization Multivesicular Body Assembly Positive Regulation Of Proteolysis Organelle Organization Regulation Of Proteasomal Protein Catabolic Process Cytokinetic Process Protein Domain Specific Binding Negative Regulation Of Translational Initiation Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Axon Arborization Autophagy Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Organelle Assembly Positive Regulation Of Protein Metabolic Process Response To Vitamin B2 C/EBP Complex Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Endosome Organization Chromatin DNA Binding Regulation Of Protein Catabolic Process Regulation Of Protein Metabolic Process Protein Localization To Vacuole CHOP-C/EBP Complex Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Protein O-acetylglucosaminyltransferase Activity Regulation Of Translational Initiation White Fat Cell Proliferation Negative Regulation Of Protein Catabolic Process Developmental Cell Growth Cell Division Identical Protein Binding Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Intracellular Protein Localization Positive Regulation Of Aggrephagy
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