SPAST and RTN1

Number of citations of the paper that reports this interaction (PubMedID 16602018)
0

Data Source:
HPRD (in vivo, in vitro)

		SPAST	RTN1
Description		spastin	reticulon 1
Image			No pdb structure
GO Annotations	Cellular Component	Spindle Pole Nucleus Nucleoplasm Cytoplasm Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Droplet Centrosome Spindle Cytosol Cytoskeleton Microtubule Microtubule Cytoskeleton Membrane Axon Midbody Cytoplasmic Vesicle Nuclear Membrane Cell Projection Perinuclear Region Of Cytoplasm Extracellular Exosome Endoplasmic Reticulum Tubular Network Axon Cytoplasm	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Postsynaptic Density Membrane Nuclear Body Dendrite Neuron Projection Neuronal Cell Body
	Molecular Function	Nucleotide Binding Catalytic Activity Protein Binding ATP Binding Microtubule Binding Microtubule Severing ATPase Activity Isomerase Activity ATP Hydrolysis Activity Alpha-tubulin Binding Protein-containing Complex Binding Beta-tubulin Binding	Protein Binding
	Biological Process	Mitotic Cytokinesis Microtubule Bundle Formation Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Mitotic Nuclear Membrane Reassembly Nervous System Development Axonogenesis Anterograde Axonal Transport Exit From Mitosis Axonal Transport Of Mitochondrion Central Nervous System Neuron Axonogenesis Cell Differentiation Positive Regulation Of Microtubule Depolymerization Nuclear Membrane Reassembly Positive Regulation Of Cytokinesis Cytokinetic Process Protein Hexamerization Microtubule Severing Mitotic Spindle Disassembly Protein Homooligomerization Cell Division Cytoskeleton-dependent Cytokinesis Membrane Fission	Brain Development Neuron Differentiation Endoplasmic Reticulum Tubular Network Formation Negative Regulation Of Amyloid-beta Formation Endoplasmic Reticulum Tubular Network Membrane Organization
Pathways		Sealing of the nuclear envelope (NE) by ESCRT-III
Drugs
Diseases		Hereditary spastic paraplegia (SPG)
GWAS		Apolipoprotein A1 levels ( 32203549) Bisphosphonate-associated atypical femoral fracture ( 31006051) Inflammatory biomarkers ( 24182552) Interleukin-18 levels ( 31584380) Male-pattern baldness ( 28196072)	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Broad depression or schizophrenia ( 30626913) Putamen volume ( 31530798) Schizophrenia ( 30285260)
Interacting Genes		11 interacting genes: CEBPA CHMP1B CSNK2A1 DCAF8 FBXL17 IST1 OGT RIPK4 RTN1 SSNA1 USP20	15 interacting genes: ADRB2 BCL2L1 CCR4 CHRM5 DRD2 F2RL1 FGFR1 FHIP1B HDAC8 LMNA NDRG1 PLEKHF2 SDCBP SPAST UGCG
Entrez ID		6683	6252
HPRD ID		05044	02921
Ensembl ID		ENSG00000021574	ENSG00000139970
Uniprot IDs		A0A2R8Y4I8 A0A2R8YFW8 A0A2U3TZR0 E5KRP5 E5KRP6 Q9UBP0	A8K3B9 A8MT72 Q16799
PDB IDs		3EAB 3VFD 5Z6Q 5Z6R 6PEK 6PEN 7S7J
Enriched GO Terms of Interacting Partners?		MIT Domain Binding ESCRT III Complex Disassembly ESCRT Complex Disassembly Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteolysis Sin3-type Complex Midbody Abscission Regulation Of Ubiquitin-dependent Protein Catabolic Process Midbody Mitotic Cytokinetic Process Multivesicular Body Organization Multivesicular Body Assembly Positive Regulation Of Proteolysis Organelle Organization Regulation Of Proteasomal Protein Catabolic Process Cytokinetic Process Protein Domain Specific Binding Negative Regulation Of Translational Initiation Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Axon Arborization Autophagy Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Organelle Assembly Positive Regulation Of Protein Metabolic Process Response To Vitamin B2 C/EBP Complex Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Endosome Organization Chromatin DNA Binding Regulation Of Protein Catabolic Process Regulation Of Protein Metabolic Process Protein Localization To Vacuole CHOP-C/EBP Complex Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Protein O-acetylglucosaminyltransferase Activity Regulation Of Translational Initiation White Fat Cell Proliferation Negative Regulation Of Protein Catabolic Process Developmental Cell Growth Cell Division Identical Protein Binding Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Intracellular Protein Localization Positive Regulation Of Aggrephagy	Positive Regulation Of Protein-containing Complex Disassembly Regulation Of Organelle Organization Orbitofrontal Cortex Development G Protein-coupled Receptor Activity Endosome To Lysosome Transport Positive Regulation Of MAPK Cascade Regulation Of Cytokinesis Nuclear Membrane Interneuron Migration Regulation Of Cellular Component Organization Regulation Of Growth Lysosomal Transport Regulation Of System Process Regulation Of Protein-containing Complex Disassembly Negative Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Dephosphorylation Dopamine Transport Positive Regulation Of Secretion Positive Regulation Of Secretion By Cell Positive Regulation Of Protein Depolymerization Membrane Organization Regulation Of MAPK Cascade Signal Transduction Acid Secretion Monoamine Transport Neuron Migration G-protein Alpha-subunit Binding Positive Regulation Of Cellular Component Organization Vesicle-mediated Transport Regulation Of Extrinsic Apoptotic Signaling Pathway Vacuolar Transport Regulation Of Blood Pressure Regulation Of Mesenchymal Cell Proliferation Temperature Homeostasis Regulation Of Cell Division G Protein-coupled Receptor Signaling Pathway Potassium Channel Regulator Activity Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Regulation Of Systemic Arterial Blood Pressure Negative Regulation Of Blood Pressure Positive Regulation Of Mini Excitatory Postsynaptic Potential Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Release Of Cytochrome C From Mitochondria Cell Development Apoptotic Process In Bone Marrow Cell Negative Regulation Of Insulin Secretion Positive Regulation Of Cytokinesis Negative Regulation Of Peptide Secretion Positive Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Positive Regulation Of Renin Secretion Into Blood Stream
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