SPAST and FBXL17

Number of citations of the paper that reports this interaction (PubMedID 35869491)
35

Data Source:
BioGRID (enzymatic study)

		SPAST	FBXL17
Description		spastin	F-box and leucine rich repeat protein 17
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GO Annotations	Cellular Component	Spindle Pole Nucleus Nucleoplasm Cytoplasm Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Droplet Centrosome Spindle Cytosol Cytoskeleton Microtubule Microtubule Cytoskeleton Membrane Axon Midbody Cytoplasmic Vesicle Nuclear Membrane Cell Projection Perinuclear Region Of Cytoplasm Extracellular Exosome Endoplasmic Reticulum Tubular Network Axon Cytoplasm	Nucleus Nucleoplasm Cytoplasm SCF Ubiquitin Ligase Complex
	Molecular Function	Nucleotide Binding Catalytic Activity Protein Binding ATP Binding Microtubule Binding Microtubule Severing ATPase Activity Isomerase Activity ATP Hydrolysis Activity Alpha-tubulin Binding Protein-containing Complex Binding Beta-tubulin Binding	Protein Binding
	Biological Process	Mitotic Cytokinesis Microtubule Bundle Formation Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Mitotic Nuclear Membrane Reassembly Nervous System Development Axonogenesis Anterograde Axonal Transport Exit From Mitosis Axonal Transport Of Mitochondrion Central Nervous System Neuron Axonogenesis Cell Differentiation Positive Regulation Of Microtubule Depolymerization Nuclear Membrane Reassembly Positive Regulation Of Cytokinesis Cytokinetic Process Protein Hexamerization Microtubule Severing Mitotic Spindle Disassembly Protein Homooligomerization Cell Division Cytoskeleton-dependent Cytokinesis Membrane Fission	Protein Polyubiquitination Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Nervous System Development Regulation Of Smoothened Signaling Pathway Neural Crest Cell Differentiation Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways		Sealing of the nuclear envelope (NE) by ESCRT-III	Regulation of BACH1 activity
Drugs
Diseases		Hereditary spastic paraplegia (SPG)
GWAS		Apolipoprotein A1 levels ( 32203549) Bisphosphonate-associated atypical femoral fracture ( 31006051) Inflammatory biomarkers ( 24182552) Interleukin-18 levels ( 31584380) Male-pattern baldness ( 28196072)	Adult body size ( 32376654) Bipolar disorder (body mass index interaction) ( 24322204) Body mass index ( 25673413 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Carotid intima media thickness x smoking interaction ( 32117412) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Estimated glomerular filtration rate ( 31015462) Experiencing mood swings ( 29500382) Eye color ( 23118974) General factor of neuroticism ( 30867560) Hand grip strength ( 29691431) Intelligence (MTAG) ( 29326435) Intraocular pressure ( 29235454) Irritable mood ( 29500382) Mean corpuscular volume ( 32888494) Metabolite levels ( 23823483) Moderate-to-late spontaneous preterm birth ( 31194736) Neurociticism ( 29500382) Number of children ever born ( 27798627) Pulse pressure ( 30224653) Response to amphetamines ( 22952603) smoking initiation in schizophrenia ( 33691233) Smoking status (ever vs never smokers) ( 30643258) Weight ( 28552196)
Interacting Genes		11 interacting genes: CEBPA CHMP1B CSNK2A1 DCAF8 FBXL17 IST1 OGT RIPK4 RTN1 SSNA1 USP20	40 interacting genes: ACSBG2 AK9 C21orf91 CCSER1 CFAP58 CLPX COG2 ETFA FILIP1L HADH IDO1 IFT46 KBTBD8 KEAP1 KLHL12 KLHL7 MED14 METAP2 OLR1 PCCB PHF7 PPP3CB PRMT1 PSME4 PXYLP1 RLF SCG5 SCPEP1 SPAST SRBD1 SUFU TASP1 TGFBI TMEM126A TMOD1 TPP2 UAP1 USP25 ZMYM2 ZNF350
Entrez ID		6683	64839
HPRD ID		05044	10950
Ensembl ID		ENSG00000021574	ENSG00000145743
Uniprot IDs		A0A2R8Y4I8 A0A2R8YFW8 A0A2U3TZR0 E5KRP5 E5KRP6 Q9UBP0	Q9UF56
PDB IDs		3EAB 3VFD 5Z6Q 5Z6R 6PEK 6PEN 7S7J	6W66 6WCQ 8UAH 8UBT 8UBU 8UBV
Enriched GO Terms of Interacting Partners?		MIT Domain Binding ESCRT III Complex Disassembly ESCRT Complex Disassembly Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteolysis Sin3-type Complex Midbody Abscission Regulation Of Ubiquitin-dependent Protein Catabolic Process Midbody Mitotic Cytokinetic Process Multivesicular Body Organization Multivesicular Body Assembly Positive Regulation Of Proteolysis Organelle Organization Regulation Of Proteasomal Protein Catabolic Process Cytokinetic Process Protein Domain Specific Binding Negative Regulation Of Translational Initiation Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Axon Arborization Autophagy Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Organelle Assembly Positive Regulation Of Protein Metabolic Process Response To Vitamin B2 C/EBP Complex Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Endosome Organization Chromatin DNA Binding Regulation Of Protein Catabolic Process Regulation Of Protein Metabolic Process Protein Localization To Vacuole CHOP-C/EBP Complex Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Protein O-acetylglucosaminyltransferase Activity Regulation Of Translational Initiation White Fat Cell Proliferation Negative Regulation Of Protein Catabolic Process Developmental Cell Growth Cell Division Identical Protein Binding Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Intracellular Protein Localization Positive Regulation Of Aggrephagy	Proteolysis Cul3-RING Ubiquitin Ligase Complex Protein Metabolic Process Ubiquitin-like Ligase-substrate Adaptor Activity Negative Regulation Of Response To Oxidative Stress Peptidase Activator Activity Neural Crest Formation
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