SPAST

Gene Name		spastin
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Endosome Endoplasmic Reticulum Centrosome Spindle Microtubule Microtubule Cytoskeleton Integral Component Of Membrane Midbody Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Protein Binding ATP Binding Microtubule Binding Microtubule-severing ATPase Activity Alpha-tubulin Binding Beta-tubulin Binding
	Biological Process	Microtubule Bundle Formation ER To Golgi Vesicle-mediated Transport Cytokinesis, Completion Of Separation Axonogenesis Metabolic Process Positive Regulation Of Microtubule Depolymerization Cytoplasmic Microtubule Organization Protein Hexamerization Microtubule Severing Protein Homooligomerization
Pathways
Drugs
Diseases
GWAS
Protein-protein Interactions		4 interactors: CHMP1B IST1 RTN1 SSNA1
Entrez ID		6683
HPRD ID		05044
Ensembl ID		ENSG00000021574
Uniprot IDs		E5KRP5 E5KRP6 Q9UBP0
PDB IDs		3EAB 3VFD
Enriched GO Terms of Interacting Partners?		Cytokinesis Viral Capsid Secondary Envelopment Cell Cycle Process Viral Release From Host Cell Cell Cycle Ciliary Receptor Clustering Involved In Smoothened Signaling Pathway Abscission Positive Regulation Of Collateral Sprouting Regulation Of Mitotic Spindle Assembly Regulation Of Spindle Assembly Cell Division Protein Localization Regulation Of Mitotic Spindle Organization Cell Separation After Cytokinesis Mitotic Metaphase Plate Congression Mitotic Cell Cycle Process Metaphase Plate Congression Mitotic Cell Cycle Intraciliary Transport Regulation Of Centrosome Duplication Establishment Of Chromosome Localization Regulation Of Centrosome Cycle Receptor Clustering
Tagcloud ?		accounts autosomal backgroundhereditary cassette conclusionsspg4 determinants earlier families hsp hsps inverted limbs mark mark0 mark18 mark19 methodsa paraplegias preservation question resultsmutations spg31 spg3a spg4 taiwanese weakness