NPFFR1 and NPFF

Number of citations of the paper that reports this interaction (PubMedID 11024015)
0

Data Source:
HPRD (in vitro, in vivo)

		NPFFR1	NPFF
Description		neuropeptide FF receptor 1	neuropeptide FF-amide peptide precursor
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cilium Membrane	Extracellular Region Extracellular Space Dendrite Vesicle Perikaryon Axon Terminus Postsynapse Neuronal Dense Core Vesicle
	Molecular Function	G Protein-coupled Receptor Activity Protein Binding Neuropeptide Receptor Activity	G Protein-coupled Receptor Binding Signaling Receptor Binding Neuropeptide Hormone Activity Protein Binding Neuropeptide Activity
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Cellular Response To Hormone Stimulus	Acute Inflammatory Response To Antigenic Stimulus Regulation Of Membrane Depolarization Positive Regulation Of Cytosolic Calcium Ion Concentration Neuropeptide Signaling Pathway Chemical Synaptic Transmission Response To Xenobiotic Stimulus Negative Regulation Of Heart Rate Spinal Cord Development Vasopressin Secretion Negative Regulation Of Appetite Positive Regulation Of Blood Pressure Negative Regulation Of Insulin Secretion Excitatory Postsynaptic Potential Maternal Process Involved In Female Pregnancy Somatostatin Secretion
Pathways		Orexin and neuropeptides FF and QRFP bind to their respective receptors G alpha (q) signalling events	Orexin and neuropeptides FF and QRFP bind to their respective receptors G alpha (q) signalling events
Drugs
Diseases
GWAS		Acute lymphoblastic leukemia (childhood) ( 23007406) Body size at age 10 ( 32376654) Cognitive decline rate in late mild cognitive impairment ( 26252872) Squamous cell lung carcinoma ( 28604730)	Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		3 interacting genes: NPFF TCP11 UBC	4 interacting genes: NPFFR1 NPFFR2 NPY ZDHHC17
Entrez ID		64106	8620
HPRD ID		12120	06869
Ensembl ID		ENSG00000148734	ENSG00000139574
Uniprot IDs		Q9GZQ6	O15130
PDB IDs
Enriched GO Terms of Interacting Partners?		Vesicle Neuropeptide Activity Somatostatin Secretion Vasopressin Secretion Regulation Of Sperm Capacitation Protein Kinase A Signaling Negative Regulation Of Appetite Negative Regulation Of Heart Rate Protein Tag Activity Regulation Of Response To Food Acute Inflammatory Response To Antigenic Stimulus Regulation Of Cell Maturation Negative Regulation Of Blood Circulation Neuronal Dense Core Vesicle Negative Regulation Of Heart Contraction Regulation Of Appetite G Protein-coupled Receptor Signaling Pathway Neuropeptide Hormone Activity Spinal Cord Development Regulation Of Response To Nutrient Levels Inflammatory Response To Antigenic Stimulus Maternal Process Involved In Female Pregnancy Positive Regulation Of Blood Pressure Negative Regulation Of Insulin Secretion Negative Regulation Of Peptide Secretion	Neuropeptide Signaling Pathway Neuropeptide Receptor Activity G Protein-coupled Receptor Activity Short-day Photoperiodism Regulation Of MAPK Cascade Perforant Pathway To Dendrate Granule Cell Synapse G Protein-coupled Receptor Signaling Pathway Regulation Of Nerve Growth Factor Production Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Neuropeptide Y Receptor Binding Positive Regulation Of Eating Behavior Positive Regulation Of Response To Food Positive Regulation Of Appetite Opioid Receptor Binding Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus Positive Regulation Of Dopamine Metabolic Process Protein-cysteine S-myristoyltransferase Activity Protein-cysteine S-stearoyltransferase Activity Regulation Of ERK1 And ERK2 Cascade Regulation Of Eating Behavior Monocyte Activation Antifungal Humoral Response Synaptic Signaling Via Neuropeptide Intestinal Epithelial Cell Differentiation Adult Feeding Behavior Positive Regulation Of Feeding Behavior Cellular Response To Hormone Stimulus Regulation Of Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Acute Inflammatory Response Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Signaling Receptor Binding Golgi-associated Vesicle Membrane Response To Yeast Regulation Of Acute Inflammatory Response To Antigenic Stimulus Regulation Of Response To Food Lipoprotein Transport Protein Palmitoylation Regulation Of Dopamine Metabolic Process Modulation Of Chemical Synaptic Transmission Palmitoyltransferase Activity Regulation Of Modification Of Synaptic Structure Protein-cysteine S-palmitoyltransferase Activity Neuronal Dense Core Vesicle Regulation Of Appetite Regulation Of Intracellular Signal Transduction Regulation Of Feeding Behavior Photoperiodism Protein Lipidation Positive Regulation Of Behavior
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