ZC3HC1 and TPR

Number of citations: 117 (PubMedID 36857168)
Data Source: BioGRID (two hybrid)

		ZC3HC1	TPR
Name		zinc finger C3HC-type containing 1	translocated promoter region, nuclear basket protein
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nucleoplasm Nuclear Membrane Nuclear Pore Nuclear Basket	Chromosome, Centromeric Region Kinetochore Nucleus Nuclear Envelope Nuclear Pore Nucleoplasm Chromosome Cytoplasm Spindle Cytoskeleton Cytoplasmic Dynein Complex Membrane Nuclear Membrane Nuclear Periphery Nuclear Inclusion Body Nuclear Pore Nuclear Basket Mitotic Spindle
	Molecular Function	Protein Binding Zinc Ion Binding Protein Kinase Binding Metal Ion Binding	Chromatin Binding RNA Binding MRNA Binding Protein Binding Tubulin Binding Structural Constituent Of Nuclear Pore Heat Shock Protein Binding Protein Homodimerization Activity Protein-membrane Adaptor Activity Mitogen-activated Protein Kinase Binding Dynein Complex Binding
	Biological Process	Protein Ubiquitination Cell Division	Negative Regulation Of Transcription By RNA Polymerase II RNA Import Into Nucleus RNA Export From Nucleus MRNA Export From Nucleus Protein Import Into Nucleus Protein Export From Nucleus Intracellular Protein Transport Nucleocytoplasmic Transport Nuclear Pore Organization Mitotic Spindle Assembly Checkpoint Signaling Regulation Of MRNA Export From Nucleus Regulation Of Mitotic Sister Chromatid Separation Protein Transport Positive Regulation Of Heterochromatin Formation Regulation Of Protein Stability MRNA Export From Nucleus In Response To Heat Stress Regulation Of Protein Localization Cellular Response To Heat Cellular Response To Interferon-alpha Regulation Of Protein Import Into Nucleus Positive Regulation Of Protein Import Into Nucleus Nuclear Matrix Organization Negative Regulation Of Translational Initiation Positive Regulation Of Nucleocytoplasmic Transport Regulation Of Protein Export From Nucleus Positive Regulation Of Protein Export From Nucleus Negative Regulation Of RNA Export From Nucleus MRNA Transport Nuclear Export Nuclear Pore Complex Assembly Cell Division Response To Epidermal Growth Factor Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Positive Regulation Of Intracellular Protein Transport Regulation Of Mitotic Spindle Assembly
Pathways		Nuclear events stimulated by ALK signaling in cancer	ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs IPs transport between nucleus and cytosol IP3 and IP4 transport between cytosol and nucleus IP6 and IP7 transport between cytosol and nucleus snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events SARS-CoV-2 activates/modulates innate and adaptive immune responses Signaling by ALK fusions and activated point mutants
Diseases		None	Thyroid cancer
GWAS		Coronary artery disease ( 24262325 26343387 33020668 32469254 29212778 ) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975 ) Coronary artery disease or ischemic stroke ( 24262325 ) Coronary artery disease or large artery stroke ( 24262325 ) Coronary heart disease ( 21378990 ) Diastolic blood pressure ( 27618452 27841878 ) Eosinophil count ( 32888494 ) Hematocrit ( 32888494 ) Hemoglobin ( 32888494 ) Hemoglobin levels ( 32327693 ) Myocardial infarction ( 33532862 26343387 ) Neutrophil count ( 32888494 ) Parental lifespan ( 30642433 ) Platelet count ( 27863252 32888494 ) Plateletcrit ( 27863252 32888494 ) Red cell distribution width ( 32888494 ) Systolic blood pressure ( 28739976 27841878 27618452 ) White blood cell count ( 32888494 ) White blood cell count (basophil) ( 27863252 )	No GWAS studies recorded
Novel Interactors		None recorded	1 novel interactors: TNFSF4
Interacting Genes		11 interacting genes: ALK APP CUL1 MAPK3 PDPK1 TNFSF11 TPR TRIM55 TRIM63 TSC22D1 YWHAE	19 interacting genes: APC CDK1 ERCC6 HTT IFI16 MAD1L1 MAP3K4 MAPK1 MDM2 MECOM NUP153 NUP98 PRKACA SHC1 SUMO2 USP7 WEE2-AS1 YWHAQ ZC3HC1
Entrez ID		51530	7175
HPRD ID		11390	08927
Ensembl ID		ENSG00000091732	ENSG00000047410
Uniprot IDs		C9J0I9 Q86WB0	P12270
PDB IDs		Not available	5TO5 5TO6 5TO7 5TVB
GO Terms Enriched among Interactors		Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Intracellular Signal Transduction Regulation Of Toll-like Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Response To Epidermal Growth Factor Intracellular Signaling Cassette Signal Transduction Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Response To Stress Peptidyl-tyrosine Autophosphorylation Response To Cytokine Response To Peptide Protein Modification Process Identical Protein Binding Regulation Of Non-canonical NF-kappaB Signal Transduction Response To Growth Factor Immune System Process Protein Autophosphorylation Negative Regulation Of Catabolic Process Protein Metabolic Process Positive Regulation Of Protein Export From Nucleus Negative Regulation Of Toll-like Receptor Signaling Pathway Regulation Of Defense Response Positive Regulation Of Transport Regulation Of Calcium Ion Transmembrane Transport Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Cell Development Positive Regulation Of Protein Localization Calcium-mediated Signaling Positive Regulation Of Defense Response Positive Regulation Of Inflammatory Response Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Regulation Of Immune System Process Regulation Of Transport Positive Regulation Of ERK1 And ERK2 Cascade Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Immune System Process Regulation Of Cellular Localization Negative Regulation Of Immune System Process Regulation Of Protein Export From Nucleus Positive Regulation Of Apoptotic Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction	Nuclear Pore Nuclear Basket Intracellular Signal Transduction Positive Regulation Of Metabolic Process Regulation Of Chromosome Organization Regulation Of Intracellular Transport Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Chromosome Organization Nucleoplasm Regulation Of Nucleocytoplasmic Transport Cellular Response To Nutrient Levels Regulation Of DNA Metabolic Process Positive Regulation Of DNA Metabolic Process Regulation Of Primary Metabolic Process DNA Damage Response Regulation Of Cellular Localization Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Mitotic Sister Chromatid Segregation Positive Regulation Of Nucleocytoplasmic Transport Regulation Of Protein Catabolic Process Positive Regulation Of Biosynthetic Process RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Nuclear Pore Complex Assembly Protein Localization To Organelle Negative Regulation Of Metabolic Process Transcription-coupled Nucleotide-excision Repair P53 Binding Regulation Of Proteasomal Protein Catabolic Process Nuclear Inclusion Body Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Nuclear Envelope Insulin Receptor Signaling Pathway Nucleus Regulation Of Macromolecule Biosynthetic Process Regulation Of Metaphase Plate Congression Response To UV-C Nuclear Pore Organization Negative Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Protein Metabolic Process Regulation Of Cell Cycle MAPK Cascade Nucleus Organization Positive Regulation Of Intracellular Protein Transport