SCARF1 and MRM3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SCARF1	MRM3
Description		scavenger receptor class F member 1	mitochondrial rRNA methyltransferase 3
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GO Annotations	Cellular Component	Plasma Membrane Membrane Endocytic Vesicle Membrane	Cytoplasm Mitochondrion Mitochondrial Matrix
	Molecular Function	Transmembrane Signaling Receptor Activity Scavenger Receptor Activity Protein Binding Low-density Lipoprotein Particle Binding	RNA Binding Protein Binding Methyltransferase Activity RNA Methyltransferase Activity Transferase Activity Identical Protein Binding RRNA (guanosine-2'-O-)-methyltransferase Activity
	Biological Process	Cholesterol Catabolic Process Receptor-mediated Endocytosis Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Positive Regulation Of Neuron Projection Development Neuron Remodeling Dendrite Development Positive Regulation Of Axon Regeneration	RRNA 2'-O-methylation RRNA Processing RNA Processing Methylation
Pathways		Scavenging by Class F Receptors Scavenging by Class F Receptors	rRNA modification in the mitochondrion
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Intracranial aneurysm ( 30823506) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		22 interacting genes: CALR CLDN7 COQ9 CREB3L1 CYSRT1 FAM209A GJA8 GPR37L1 GPX8 HSD17B13 KCNJ6 KRTAP1-1 KRTAP10-8 KRTAP5-7 LCE1D LHFPL2 MEOX2 MRM3 NEMP1 SCARF2 SLC7A14 TGM1	16 interacting genes: AIG1 APP ARLN BTN2A2 FBXO7 FHL3 GAD2 GALNT2 JAGN1 MIP OGT SCARF1 SHANK3 TNF UBIAD1 ZFPL1
Entrez ID		8578	55178
HPRD ID		06386	15266
Ensembl ID		ENSG00000074660	ENSG00000171861
Uniprot IDs		A8K6Z5 Q14162	Q9HC36
PDB IDs		8HN0 8HNA	7OI6
Enriched GO Terms of Interacting Partners?		Cornified Envelope	Positive Regulation Of Proteolysis Amyloid-beta Complex Negative Regulation Of Blood Circulation Growth Cone Lamellipodium Neuron Projection Organization Positive Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of MiRNA Transcription Regulation Of Synapse Organization Membrane Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Response To Calcium Ion Positive Regulation Of Excitatory Postsynaptic Potential Amylin Binding Neuron Maturation Positive Regulation Of Toll Signaling Pathway Regulation Of Long-term Synaptic Potentiation Regulation Of Amyloid-beta Clearance Positive Regulation Of Long-term Synaptic Potentiation Astrocyte Activation Positive Regulation Of Synaptic Transmission Positive Regulation Of Developmental Process Positive Regulation Of Membrane Protein Ectodomain Proteolysis Dendrite Development Microglial Cell Activation Positive Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Nervous System Process Positive Regulation Of Nitric Oxide Metabolic Process Regulation Of Membrane Protein Ectodomain Proteolysis Neuron Remodeling Regulation Of Generation Of Precursor Metabolites And Energy Leukocyte Activation Involved In Inflammatory Response Negative Regulation Of Bile Acid Secretion Positive Regulation Of Translational Initiation By Iron Positive Regulation Of Interleukin-33 Production Response To Gram-negative Bacterium Positive Regulation Of Translational Initiation Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Branching Involved In Lung Morphogenesis Response To Monosaccharide Response To Carbohydrate Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Vitamin K Biosynthetic Process Menaquinone Biosynthetic Process Modulation Of Excitatory Postsynaptic Potential Cellular Response To Amyloid-beta
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