MRM3 and ZFPL1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MRM3	ZFPL1
Description		mitochondrial rRNA methyltransferase 3	zinc finger protein like 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Matrix	Nucleus Golgi Apparatus Membrane
	Molecular Function	RNA Binding Protein Binding Methyltransferase Activity RNA Methyltransferase Activity Transferase Activity Identical Protein Binding RRNA (guanosine-2'-O-)-methyltransferase Activity	DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	RRNA 2'-O-methylation RRNA Processing RNA Processing Methylation	Regulation Of DNA-templated Transcription Vesicle-mediated Transport
Pathways		rRNA modification in the mitochondrion
Drugs
Diseases
GWAS
Interacting Genes		16 interacting genes: AIG1 APP ARLN BTN2A2 FBXO7 FHL3 GAD2 GALNT2 JAGN1 MIP OGT SCARF1 SHANK3 TNF UBIAD1 ZFPL1	64 interacting genes: AHNAK2 AQP6 ATP5MF BIK BSND CD3E CGRRF1 CLEC10A CLEC7A CPLX4 CREB3L1 CYBRD1 EBP ELOVL4 ERGIC3 FAM209A FATE1 FKBP7 FKBP8 FNDC9 FRMD3 GORAB GPR42 HIBADH KASH5 KLRC1 LDLRAD1 LEUTX LIME1 LINC00839 MFF MGST3 MIP MRM3 MRPS18B MS4A3 MTERF3 PGRMC2 PLEKHO1 PVR RELL2 SCN3B SGMS2 SHISAL1 SLC10A6 SLC19A3 SLC71A2 SLC7A14 SMIM3 SSMEM1 STX1A STX2 STX4 SYAP1 SYT1 TEX29 TM4SF19 TMEM106C TMEM139 TMEM14B TMEM237 TMEM31 TMPRSS2 TSTD2
Entrez ID		55178	7542
HPRD ID		15266	15729
Ensembl ID		ENSG00000171861	ENSG00000162300
Uniprot IDs		Q9HC36	O95159
PDB IDs		7OI6
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Proteolysis Amyloid-beta Complex Negative Regulation Of Blood Circulation Growth Cone Lamellipodium Neuron Projection Organization Positive Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of MiRNA Transcription Regulation Of Synapse Organization Membrane Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Response To Calcium Ion Positive Regulation Of Excitatory Postsynaptic Potential Amylin Binding Neuron Maturation Positive Regulation Of Toll Signaling Pathway Regulation Of Long-term Synaptic Potentiation Regulation Of Amyloid-beta Clearance Positive Regulation Of Long-term Synaptic Potentiation Astrocyte Activation Positive Regulation Of Synaptic Transmission Positive Regulation Of Developmental Process Positive Regulation Of Membrane Protein Ectodomain Proteolysis Dendrite Development Microglial Cell Activation Positive Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Nervous System Process Positive Regulation Of Nitric Oxide Metabolic Process Regulation Of Membrane Protein Ectodomain Proteolysis Neuron Remodeling Regulation Of Generation Of Precursor Metabolites And Energy Leukocyte Activation Involved In Inflammatory Response Negative Regulation Of Bile Acid Secretion Positive Regulation Of Translational Initiation By Iron Positive Regulation Of Interleukin-33 Production Response To Gram-negative Bacterium Positive Regulation Of Translational Initiation Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Branching Involved In Lung Morphogenesis Response To Monosaccharide Response To Carbohydrate Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Vitamin K Biosynthetic Process Menaquinone Biosynthetic Process Modulation Of Excitatory Postsynaptic Potential Cellular Response To Amyloid-beta	Membrane SNARE Binding Protein Binding SNARE Complex Endomembrane System Vesicle Docking Cornified Envelope Assembly Organelle Localization By Membrane Tethering Synaptic Vesicle Exocytosis Membrane Docking SNAP Receptor Activity
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