CDC14B and MCC

Number of citations of the paper that reports this interaction (PubMedID 24412244)
0

Data Source:
BioGRID (two hybrid)

		CDC14B	MCC
Description		cell division cycle 14B	MCC regulator of Wnt signaling pathway
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GO Annotations	Cellular Component	Spindle Pole Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Cell Junction Mitotic Spindle	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Lamellipodium Cell Projection
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity	Protein Binding Signaling Receptor Activity
	Biological Process	Microtubule Cytoskeleton Organization DNA Repair Protein Dephosphorylation DNA Damage Response Mitotic G2 DNA Damage Checkpoint Signaling Regulation Of Exit From Mitosis Positive Regulation Of Cytokinesis Cilium Assembly Positive Regulation Of Ubiquitin Protein Ligase Activity	Signal Transduction Negative Regulation Of Epithelial Cell Migration Wnt Signaling Pathway Establishment Of Protein Localization Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways		MAPK6/MAPK4 signaling
Drugs
Diseases
GWAS		Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Household income ( 31844048) Intelligence (MTAG) ( 29326435) Peginterferon alfa-2a treatment response in chronic hepatitis B infection ( 30972912) Waist circumference adjusted for body mass index ( 34021172)	Adult body size ( 32376654) Brain cytoarchitecture ( 20308991) Cerebral amyloid angiopathy ( 25188341) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) Femur bone mineral density x serum urate levels interaction ( 34046847) Height ( 31562340) Metabolite levels ( 23823483) Neurofibrillary tangles ( 31497858) Nicotine dependence symptom count ( 25555482) Triglyceride levels ( 32203549) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		20 interacting genes: BCL10 BUB1 CCND1 CDKN2A CHEK1 DLC1 MCC MFAP1 MLH3 MSH2 MTDH PRKAB2 PSMB1 SIRT2 SKP2 SMAD4 SPANXN2 STK11 TP53 ZNF696	77 interacting genes: ALDOB ANP32B APP BAAT C8orf33 C8orf48 CBX5 CBX8 CCDC112 CCDC146 CCDC180 CCDC185 CCDC187 CDC14B CDK8 CDKL3 CEP57L1 CEP95 CFAP58 CYLC2 DNAAF4 DYNC1I1 ELOA ERBIN ESRRG FAM161A FGF16 FRAT2 GTF2E2 HEMGN HSD17B3 KAT5 KEAP1 KIF3C KIFC3 LRRC45 MSANTD3 MTNR1A NANS NEK2 NFKBIB NOL12 PCCA PNKP POLL PRPF18 RASAL2 RCOR3 SEC61B SFRP4 SLTM SLU7 SYT17 SYT6 TCEA2 TCEANC TGFB1 THAP7 TRMO TRMT2A TSHZ2 TSTD2 TXLNA UTP14C ZBTB48 ZNF12 ZNF189 ZNF202 ZNF264 ZNF3 ZNF35 ZNF417 ZNF438 ZNF497 ZNF543 ZNF648 ZNF792
Entrez ID		8555	4163
HPRD ID		04615	01157
Ensembl ID		ENSG00000081377	ENSG00000171444
Uniprot IDs		A0A9L9PY50 O60729	P23508
PDB IDs		1OHC 1OHD 1OHE	6MTU 6MTV
Enriched GO Terms of Interacting Partners?		Nucleus Nucleoplasm Regulation Of Cell Cycle Phase Transition Replicative Senescence Mitotic DNA Integrity Checkpoint Signaling Regulation Of Apoptotic Process Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Mitotic DNA Damage Checkpoint Signaling Regulation Of Cell Cycle Apoptotic Signaling Pathway Positive Regulation Of Execution Phase Of Apoptosis Regulation Of Programmed Cell Death Negative Regulation Of Cell Cycle Response To X-ray Negative Regulation Of Mitotic Cell Cycle DNA Damage Checkpoint Signaling Negative Regulation Of Cell Cycle Phase Transition NF-kappaB Binding Regulation Of Cell Population Proliferation Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Cell Cycle Process Negative Regulation Of Cell Cycle Process Intracellular Signal Transduction Negative Regulation Of Cell Population Proliferation Positive Regulation Of Post-translational Protein Modification Centromeric DNA Binding Response To Ionizing Radiation Signal Transduction In Response To DNA Damage Positive Regulation Of Apoptotic Process Response To UV Positive Regulation Of Programmed Cell Death Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Cell Growth Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of Catabolic Process Positive Regulation Of Protein Modification Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Mismatched DNA Binding Regulation Of Protein Ubiquitination P53 Binding Regulation Of Protein Modification Process MDM2/MDM4 Family Protein Binding General Transcription Initiation Factor Binding Centrosome Negative Regulation Of Growth Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Cellular Component Organization Mitotic G1 DNA Damage Checkpoint Signaling Mammary Gland Epithelial Cell Proliferation	Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Centrosome
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