RHPN2 and KRT18

Number of citations of the paper that reports this interaction (PubMedID 12473120)
0

Data Source:
HPRD (two hybrid, in vitro)

		RHPN2	KRT18
Description		rhophilin Rho GTPase binding protein 2	keratin 18
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Perinuclear Region Of Cytoplasm	Nucleus Nucleolus Cytoplasm Microtubule Organizing Center Cytosol Cytoskeleton Intermediate Filament Adherens Junction Nuclear Matrix Centriolar Satellite Keratin Filament Perinuclear Region Of Cytoplasm Extracellular Exosome Cell Periphery
	Molecular Function		RNA Binding Structural Molecule Activity Protein Binding Scaffold Protein Binding Cadherin Binding Involved In Cell-cell Adhesion
	Biological Process	Glomerular Filtration Signal Transduction Negative Regulation Of Stress Fiber Assembly	Anatomical Structure Morphogenesis Tumor Necrosis Factor-mediated Signaling Pathway Golgi To Plasma Membrane Protein Transport Negative Regulation Of Apoptotic Process Intermediate Filament Cytoskeleton Organization Extrinsic Apoptotic Signaling Pathway Hepatocyte Apoptotic Process Cell-cell Adhesion
Pathways		RHO GTPases Activate Rhotekin and Rhophilins RHO GTPases Activate Rhotekin and Rhophilins RHOA GTPase cycle RHOB GTPase cycle	Keratinization Formation of the cornified envelope Developmental Lineage of Mammary Gland Luminal Epithelial Cells Developmental Lineage of Mammary Gland Alveolar Cells
Drugs
Diseases
GWAS		Bone ultrasound measurement (broadband ultrasound attenuation) ( 28472463) Brain morphology (MOSTest) ( 32665545) Colorectal cancer ( 19011631 24737748 24836286 30529582 31826910) Colorectal cancer or advanced adenoma ( 30510241) Femoral neck bone mineral density ( 29499414) Heel bone mineral density ( 28869591 30598549) Liver enzyme levels (alkaline phosphatase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Lumbar spine bone mineral density ( 29499414) Macular thickness ( 30535121) Nonsyndromic cleft lip with or without cleft palate ( 33898419) Obesity-related traits ( 23251661) Optic disc size ( 31809533) Serum alkaline phosphatase levels ( 33547301)	Diffusing capacity of carbon monoxide ( 30694715) Nonsyndromic cleft lip with cleft palate ( 28232668)
Interacting Genes		6 interacting genes: KRT18 RARG RHOA RHOB SMURF1 TGFBR1	94 interacting genes: AIRIM BBS1 BBS2 BBS4 BBS7 CAMK2A CASP3 CASP6 CASP7 CASP8 CBL CCDC146 CCDC85B CCHCR1 CCNI CDC5L CDK1 COL17A1 DEDD DNAJB6 EFHC1 EGFR EP300 ESR1 EXOC8 FRAT1 FXR1 FXR2 GIT2 GOLGA2 GRN HAUS1 HGS HRAS HSPA1A HSPA4 HSPA5 HSPB1 IKBKG KIFC3 KPNA2 KRT15 KRT4 KRT5 KRT6A KRT6C KRT71 KRT72 KRT8 KRT81 LDOC1 LINC01554 MAPK14 NEFL NME7 ORC5 PDE4B PDE4DIP PIAS4 PKD1 PKP2 PKP3 PNN POT1 PRKCA PRKCE PSTPIP2 RAF1 RCOR3 RHPN2 RPS6KA3 SERPINE1 SHC1 SMARCD1 SVIL SYCE1 TCHP TEKT4 TNFRSF1B TRADD TSG101 TUBG1 TUBGCP4 TXN2 TXNDC11 UPF2 USH2A WBP2 YTHDC1 YWHAB YWHAE YWHAG YWHAH YWHAZ
Entrez ID		85415	3875
HPRD ID		10192	01020
Ensembl ID		ENSG00000131941	ENSG00000111057
Uniprot IDs		Q8IUC4	P05783
PDB IDs		2VSV
Enriched GO Terms of Interacting Partners?		Apoptotic Process Programmed Cell Death Cell Death Tissue Morphogenesis Endothelial Tube Morphogenesis Regulation Of Modification Of Postsynaptic Structure I-SMAD Binding Regulation Of Modification Of Synaptic Structure Anatomical Structure Morphogenesis Regulation Of Apoptotic Process Regulation Of Multicellular Organismal Development Regulation Of Programmed Cell Death Negative Regulation Of Chondrocyte Differentiation Tissue Development Negative Regulation Of Cartilage Development Wnt Signaling Pathway, Planar Cell Polarity Pathway Anatomical Structure Formation Involved In Morphogenesis Wnt Signaling Pathway Negative Regulation Of Cell Migration Tube Morphogenesis Positive Regulation Of Stress Fiber Assembly Cell Surface Receptor Signaling Pathway Morphogenesis Of An Epithelium Membrane Invagination Non-canonical Wnt Signaling Pathway Regulation Of Chondrocyte Differentiation SMAD Binding Cleavage Furrow Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Positive Regulation Of Actin Filament Bundle Assembly Rho Protein Signal Transduction Mitotic Cytokinesis Signal Transduction Cell Differentiation Regulation Of Cartilage Development Regulation Of Developmental Process Angiotensin-mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Mitotic Cleavage Furrow Formation Regulation Of Cell Size Engulfment Of Target By Autophagosome Endothelial Cell Migration Regulation Of Stem Cell Proliferation Cytoskeleton-dependent Cytokinesis Cell Periphery Regulation Of Stress Fiber Assembly Positive Regulation Of Developmental Process Nuclear Receptor-mediated Signaling Pathway Animal Organ Morphogenesis Cellular Developmental Process	Cytosol Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Intermediate Filament Organization Cytoplasm Organelle Organization Cytoskeleton Organization Intermediate Filament Keratin Filament Structural Constituent Of Skin Epidermis Cytoskeleton Establishment Of Protein Localization Nucleus Developmental Process Supramolecular Fiber Organization BBSome Regulation Of Apoptotic Process Intracellular Protein Localization Protein Domain Specific Binding Regulation Of Programmed Cell Death Cellular Component Assembly Centrosome Regulation Of Protein Metabolic Process Keratinization Establishment Of Localization In Cell Reproductive Process Response To Lipid Enzyme Binding Apoptotic Process Protein Binding Regulation Of Cellular Component Organization Programmed Cell Death Cell Death Cellular Response To Staurosporine Ciliary Basal Body Cellular Localization Negative Regulation Of Programmed Cell Death Apoptotic Signaling Pathway Regulation Of Protein Localization Intracellular Signal Transduction Hippocampus Development Regulation Of Microtubule Nucleation Phosphoserine Residue Binding Focal Adhesion Pyroptotic Inflammatory Response Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Apoptotic Process Regulation Of Macromolecule Biosynthetic Process Death-inducing Signaling Complex Desmosome Assembly
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