RHPN2

Description		rhophilin Rho GTPase binding protein 2
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Perinuclear Region Of Cytoplasm
	Molecular Function
	Biological Process	Glomerular Filtration Signal Transduction Negative Regulation Of Stress Fiber Assembly
Pathways		RHO GTPases Activate Rhotekin and Rhophilins RHO GTPases Activate Rhotekin and Rhophilins RHOA GTPase cycle RHOB GTPase cycle
Drugs
Diseases
GWAS		Bone ultrasound measurement (broadband ultrasound attenuation) ( 28472463) Brain morphology (MOSTest) ( 32665545) Colorectal cancer ( 19011631 24737748 24836286 30529582 31826910) Colorectal cancer or advanced adenoma ( 30510241) Femoral neck bone mineral density ( 29499414) Heel bone mineral density ( 28869591 30598549) Liver enzyme levels (alkaline phosphatase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Lumbar spine bone mineral density ( 29499414) Macular thickness ( 30535121) Nonsyndromic cleft lip with or without cleft palate ( 33898419) Obesity-related traits ( 23251661) Optic disc size ( 31809533) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		6 interacting genes: KRT18 RARG RHOA RHOB SMURF1 TGFBR1
Entrez ID		85415
HPRD ID		10192
Ensembl ID		ENSG00000131941
Uniprot IDs		Q8IUC4
PDB IDs		2VSV
Enriched GO Terms of Interacting Partners?		Apoptotic Process Programmed Cell Death Cell Death Tissue Morphogenesis Endothelial Tube Morphogenesis Regulation Of Modification Of Postsynaptic Structure I-SMAD Binding Regulation Of Modification Of Synaptic Structure Anatomical Structure Morphogenesis Regulation Of Apoptotic Process Regulation Of Multicellular Organismal Development Regulation Of Programmed Cell Death Negative Regulation Of Chondrocyte Differentiation Tissue Development Negative Regulation Of Cartilage Development Wnt Signaling Pathway, Planar Cell Polarity Pathway Anatomical Structure Formation Involved In Morphogenesis Wnt Signaling Pathway Negative Regulation Of Cell Migration Tube Morphogenesis Positive Regulation Of Stress Fiber Assembly Cell Surface Receptor Signaling Pathway Morphogenesis Of An Epithelium Membrane Invagination Non-canonical Wnt Signaling Pathway Regulation Of Chondrocyte Differentiation SMAD Binding Cleavage Furrow Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Positive Regulation Of Actin Filament Bundle Assembly Rho Protein Signal Transduction Mitotic Cytokinesis Signal Transduction Cell Differentiation Regulation Of Cartilage Development Regulation Of Developmental Process Angiotensin-mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Mitotic Cleavage Furrow Formation Regulation Of Cell Size Engulfment Of Target By Autophagosome Endothelial Cell Migration Regulation Of Stem Cell Proliferation Cytoskeleton-dependent Cytokinesis Cell Periphery Regulation Of Stress Fiber Assembly Positive Regulation Of Developmental Process Nuclear Receptor-mediated Signaling Pathway Animal Organ Morphogenesis Cellular Developmental Process
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