RHPN2 and RARG

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		RHPN2	RARG
Gene Name		rhophilin, Rho GTPase binding protein 2	retinoic acid receptor, gamma
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex Integral Component Of Membrane
	Molecular Function		RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Steroid Hormone Receptor Activity Retinoic Acid Receptor Activity Protein Binding Zinc Ion Binding Retinoid X Receptor Binding
	Biological Process	Signal Transduction	Negative Regulation Of Transcription From RNA Polymerase II Promoter Neural Tube Closure Glandular Epithelial Cell Development Retinal Pigment Epithelium Development Growth Plate Cartilage Chondrocyte Growth Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Regulation Of Cell Size Anterior/posterior Pattern Specification Gene Expression Embryonic Camera-type Eye Development Regulation Of Myelination Negative Regulation Of Chondrocyte Differentiation Response To Retinoic Acid Embryonic Hindlimb Morphogenesis Multicellular Organism Growth Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Embryonic Eye Morphogenesis Retinoic Acid Receptor Signaling Pathway Transmembrane Transport Canonical Wnt Signaling Pathway Face Development Trachea Cartilage Development Prostate Gland Epithelium Morphogenesis Harderian Gland Development Cellular Response To Retinoic Acid
Pathways			Generic Transcription Pathway Signaling by Retinoic Acid Nuclear Receptor transcription pathway Orphan transporters
Drugs			Adapalene Acitretin Alitretinoin Tretinoin Tazarotene Etretinate SR11254 4-[3-Oxo-3-(5,5,8,8-Tetramethyl-5,6,7,8-Tetrahydro-Naphthalen-2-Yl)-Propenyl]-Benzoic Acid CD564 Dodecyl-Alpha-D-Maltoside BMS184394 R-3-FLUORO-4-[2-HYDROXY-2-(5,5,8,8-TETRAMETHYL-5,6,7,8,-TETRAHYDRO-NAPHTALEN-2-YL)-ACETYLAMINO]-BENZOIC ACID 3-FLUORO-4-[2-HYDROXY-2-(5,5,8,8-TETRAMETHYL-5,6,7,8,-TETRAHYDRO-NAPHTALEN-2-YL)-ACETYLAMINO]-BENZOIC ACID
Diseases
GWAS		Colorectal cancer ( 19011631) Obesity-related traits ( 23251661)
Protein-Protein Interactions		6 interactors: KRT18 RARG RHOA RHOB SMURF1 TGFBR1	29 interactors: ACY3 EIF3I HMGA1 IL24 ITGB1BP2 LSR MAP6 MRPL12 MTMR6 NCOA1 NCOA3 NCOR1 NCOR2 NKX3-1 NR0B2 NR2F6 OIP5 PNRC1 PNRC2 RHPN2 RXRA RXRB RXRG SMAD3 SPHK1 SRC SRF TNIP1 ZNF576
Entrez ID		85415	5916
HPRD ID		10192	01573
Ensembl ID		ENSG00000131941	ENSG00000172819
Uniprot IDs		Q8IUC4	A8K3H3 B7Z4B4 F1D8P1 P13631
PDB IDs		2VSV	1EXA 1EXX 1FCX 1FCY 1FCZ 1FD0 2LBD 3LBD 4LBD
Enriched GO Terms of Interacting Partners?		Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Negative Regulation Of Chondrocyte Differentiation Cellular Response To Organic Substance Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cartilage Development Anatomical Structure Morphogenesis Response To Organic Substance Anatomical Structure Development Rho Protein Signal Transduction Regulation Of Chondrocyte Differentiation Signal Transduction Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cell Cycle Developmental Process Signaling Regulation Of Apoptotic Process Regulation Of Cartilage Development Cell Communication Cell Surface Receptor Signaling Pathway Positive Regulation Of Protein Import Into Nucleus Regulation Of Cell Death Skeletal System Development Golgi To Plasma Membrane CFTR Protein Transport Cellular Response To Growth Factor Stimulus Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cytokinesis Wound Healing Response To Growth Factor Negative Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Protein Localization To Nucleus Cell Differentiation Positive Regulation Of Cell Death Tissue Development Cell Activation Cell Development Cytoplasmic Transport Response To Wounding Cellular Response To Stimulus Growth Plate Cartilage Chondrocyte Growth Cell Morphogenesis Involved In Differentiation Negative Regulation Of Cell Differentiation Positive Regulation Of Intracellular Protein Transport Growth Plate Cartilage Chondrocyte Development Harderian Gland Development	Transcription Initiation From RNA Polymerase II Promoter Intracellular Receptor Signaling Pathway Transcription, DNA-templated Response To Steroid Hormone Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process DNA-templated Transcription, Initiation Response To Hormone Gene Expression Cellular Response To Organic Substance Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Cellular Response To Steroid Hormone Stimulus Response To Lipid Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Regulation Of Nucleic Acid-templated Transcription Steroid Hormone Mediated Signaling Pathway Regulation Of RNA Biosynthetic Process Response To Organic Cyclic Compound Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Hormone-mediated Signaling Pathway RNA Metabolic Process Positive Regulation Of Transcription, DNA-templated Cellular Response To Organic Cyclic Compound Cellular Response To Hormone Stimulus Cellular Response To Lipid Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Gland Development Positive Regulation Of Cellular Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Organ Development System Development Intracellular Steroid Hormone Receptor Signaling Pathway In Utero Embryonic Development Heart Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Chordate Embryonic Development Nucleobase-containing Compound Metabolic Process Embryo Development Ending In Birth Or Egg Hatching Negative Regulation Of Transcription, DNA-templated Cellular Response To Stimulus Negative Regulation Of Nucleic Acid-templated Transcription
Tagcloud ?			activating backcross chromosomes contain cosegregated enhancers fragment homology interspecific loci mapped mchr mediate none rara rarb reports responsive restriction retinoic retinoid rflvs rxr subclass syntenic terms trans variants
Tagcloud (Difference) ?			activating backcross chromosomes contain cosegregated enhancers fragment homology interspecific loci mapped mchr mediate none rara rarb reports responsive restriction retinoic retinoid rflvs rxr subclass syntenic terms trans variants
Tagcloud (Intersection) ?