NFIA and NHLH1

Number of citations of the paper that reports this interaction (PubMedID 35140242)
106

Data Source:
BioGRID (proximity labelling technology, pull down)

		NFIA	NHLH1
Description		nuclear factor I A	nescient helix-loop-helix 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cell Junction	Chromatin Nucleus
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding DNA-binding Transcription Factor Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Cell Morphogenesis DNA Replication Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Response To Wounding Exit From Mitosis Gene Expression Glial Cell Proliferation Viral Genome Replication Glial Cell Fate Specification Neurogenesis BMP Signaling Pathway Limb Morphogenesis Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Neuron Fate Specification Generation Of Neurons Cartilage Development Retina Development In Camera-type Eye Synapse Maturation Neural Precursor Cell Proliferation Ureter Development	Regulation Of Transcription By RNA Polymerase II Central Nervous System Development Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II
Pathways		RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation
Drugs
Diseases
GWAS		Arthritis (oligoarticular juvenile idiopathic) ( 34101054) Autism ( 30675382) Bipolar disorder ( 21738484) Blond vs. brown/black hair color ( 30531825) Celiac disease ( 20190752 25920553 30572963) Cobalt levels ( 26025379) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic conduction measures ( 23463857) Electrocardiographic traits (multivariate) ( 32602732) Erectile dysfunction ( 30583798) Feeling nervous ( 29500382) General risk tolerance (MTAG) ( 30643258) Global electrical heterogeneity phenotypes ( 29622589) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549) Hip circumference adjusted for BMI ( 28552196) Homeostasis model assessment of insulin resistance ( 33381925) JT interval (sulfonylurea treatment interaction) ( 27958378) Myopia ( 27182965) Number of sexual partners ( 30643258) Plasma anti-thyroglobulin and anti-thyroid peroxidase levels (bivariate analysis) ( 29678681) Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid) ( 21829377) PR interval ( 32439900) QRS duration ( 27577874 27659466 30679814) QT interval (sulfonylurea treatment interaction) ( 27958378) Refractive error ( 32231278) Regular attendance at a religious group ( 29970889) Risk-taking tendency (4-domain principal component model) ( 30643258) Thyroid hormone levels ( 23408906) Thyroid stimulating hormone levels ( 32769997) Triglyceride levels ( 32203549)
Interacting Genes		20 interacting genes: CREBBP ELK3 ERG ETV7 FBXO7 FOS FOXL1 GABARAPL1 GATA2 GATA3 KLF16 KLF8 LHX2 LHX3 NHLH1 PLEKHF2 SFN SMAD2 TBXT UBC	12 interacting genes: CCT7 CENPP CSRP3 INO80E LMO1 LMO2 LMO4 NFIA NFIB PIM1 PSME2 TCF3
Entrez ID		4774	4807
HPRD ID		09007	01212
Ensembl ID		ENSG00000162599	ENSG00000171786
Uniprot IDs		Q12857	Q02575 Q5T203
PDB IDs
Enriched GO Terms of Interacting Partners?		Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Transcription By RNA Polymerase II Sequence-specific Double-stranded DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Sequence-specific DNA Binding DNA-binding Transcription Factor Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Cell Differentiation Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Coactivator Binding Cellular Developmental Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Regulation Of Primary Metabolic Process Transcription Regulator Complex Neuroepithelial Cell Differentiation Negative Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Chromatin Binding Transcription Coregulator Binding Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Thyroid-stimulating Hormone-secreting Cell Differentiation Regulation Of Macromolecule Metabolic Process Positive Regulation Of MiRNA Transcription Mesoderm Development RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Macromolecule Biosynthetic Process Neuron Differentiation Positive Regulation Of MiRNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Developmental Process Positive Regulation Of Biosynthetic Process	Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process DNA-binding Transcription Factor Binding Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Neuron Fate Specification Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Glial Cell Fate Specification Nucleoplasm Cell Fate Specification Regulation Of DNA-templated Transcription Regulation Of Macromolecule Metabolic Process Regulation Of RNA Biosynthetic Process Exit From Mitosis Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Generation Of Neurons Regulation Of Macromolecule Biosynthetic Process BHLH Transcription Factor Binding Glial Cell Proliferation Regulation Of Transcription By RNA Polymerase II Transcription Regulator Complex Negative Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Lung Ciliated Cell Differentiation Positive Regulation Of Cardioblast Proliferation Positive Regulation Of Actin Filament Severing Regulation Of Gene Expression Positive Regulation Of Telomere Maintenance Retina Development In Camera-type Eye DNA Metabolic Process Cell Differentiation Involved In Salivary Gland Development Negative Regulation Of Mesenchymal Cell Proliferation Involved In Lung Development Negative Regulation Of Actin Filament Severing Nucleus Regulation Of Multicellular Organismal Process Regulation Of Stem Cell Proliferation Regulation Of T Cell Homeostatic Proliferation Neural Precursor Cell Proliferation Principal Sensory Nucleus Of Trigeminal Nerve Development Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Proteasome Activator Complex Vitamin D Response Element Binding Ventral Spinal Cord Interneuron Differentiation Positive Regulation Of Chromosome Organization
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