ACE2 and APOE

Number of citations of the paper that reports this interaction (PubMedID 36759834)
57

Data Source:
BioGRID (pull down)

		ACE2	APOE
Description		angiotensin converting enzyme 2	apolipoprotein E
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen Plasma Membrane Cilium Cell Surface Membrane Apical Plasma Membrane Endocytic Vesicle Membrane Brush Border Membrane Cell Projection Membrane Raft Extracellular Exosome	Extracellular Region Extracellular Space Nucleus Cytoplasm Endosome Early Endosome Multivesicular Body Endoplasmic Reticulum Endoplasmic Reticulum Lumen Golgi Apparatus Plasma Membrane Membrane Dendrite Clathrin-coated Endocytic Vesicle Membrane Extracellular Matrix Chylomicron Remnant Very-low-density Lipoprotein Particle Low-density Lipoprotein Particle Intermediate-density Lipoprotein Particle High-density Lipoprotein Particle Discoidal High-density Lipoprotein Particle Melanosome Chylomicron Neuronal Cell Body Synaptic Cleft Extracellular Exosome Endocytic Vesicle Lumen Blood Microparticle Multivesicular Body, Internal Vesicle Glutamatergic Synapse Extracellular Vesicle Lipoprotein Particle
	Molecular Function	Virus Receptor Activity Endopeptidase Activity Carboxypeptidase Activity Metallocarboxypeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Peptidyl-dipeptidase Activity Zinc Ion Binding Hydrolase Activity Identical Protein Binding Metal Ion Binding Transporter Activator Activity	Amyloid-beta Binding Signaling Receptor Binding Structural Molecule Activity Lipid Transporter Activity Protein Binding Phospholipid Binding Heparin Binding Lipid Binding Antioxidant Activity Enzyme Binding Identical Protein Binding Protein Homodimerization Activity Heparan Sulfate Proteoglycan Binding Protein-containing Complex Binding Metal Chelating Activity Protein Dimerization Activity Receptor Ligand Activity Tau Protein Binding Low-density Lipoprotein Particle Receptor Binding Phosphatidylcholine-sterol O-acyltransferase Activator Activity Very-low-density Lipoprotein Particle Receptor Binding Lipoprotein Particle Binding Cholesterol Transfer Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cytokine Production Angiotensin Maturation Angiotensin-mediated Drinking Behavior Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Proteolysis Tryptophan Transport Viral Life Cycle Receptor-mediated Endocytosis Of Virus By Host Cell Viral Translation Regulation Of Vasoconstriction Regulation Of Cell Population Proliferation Ceramide Biosynthetic Process Symbiont Entry Into Host Cell Receptor-mediated Virion Attachment To Host Cell Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Inflammatory Response Positive Regulation Of Amino Acid Transport Maternal Process Involved In Female Pregnancy Positive Regulation Of Cardiac Muscle Contraction Membrane Fusion Negative Regulation Of ERK1 And ERK2 Cascade Blood Vessel Diameter Maintenance Entry Receptor-mediated Virion Attachment To Host Cell Positive Regulation Of Gap Junction Assembly Regulation Of Cardiac Conduction Positive Regulation Of L-proline Import Across Plasma Membrane Positive Regulation Of Reactive Oxygen Species Metabolic Process	Response To Reactive Oxygen Species Negative Regulation Of Endothelial Cell Proliferation Response To Dietary Excess Lipid Metabolic Process Triglyceride Metabolic Process Cholesterol Catabolic Process Lipid Transport Intracellular Calcium Ion Homeostasis Receptor-mediated Endocytosis Response To Oxidative Stress Cytoskeleton Organization G Protein-coupled Receptor Signaling Pathway Synaptic Transmission, Cholinergic Long-term Memory Steroid Metabolic Process Cholesterol Metabolic Process Gene Expression Regulation Of Gene Expression Negative Regulation Of Platelet Activation Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Gene Expression Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Cholesterol Efflux Lipid Transport Involved In Lipid Storage Positive Regulation Of Neuron Projection Development Negative Regulation Of Neuron Projection Development Long-chain Fatty Acid Transport Protein Import Virion Assembly Negative Regulation Of Blood Coagulation Regulation Of Axon Extension Neuron Projection Development Melanosome Organization Regulation Of Cdc42 Protein Signal Transduction Positive Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Cholesterol Efflux Phospholipid Efflux Very-low-density Lipoprotein Particle Remodeling Low-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Assembly Chylomicron Remnant Clearance High-density Lipoprotein Particle Clearance Very-low-density Lipoprotein Particle Clearance Locomotory Exploration Behavior Nitric Oxide-cGMP-mediated Signaling Lipoprotein Metabolic Process Lipoprotein Biosynthetic Process Lipoprotein Catabolic Process Vasodilation Cholesterol Homeostasis Regulation Of Apoptotic Process Amyloid Precursor Protein Metabolic Process Regulation Of Protein-containing Complex Assembly Negative Regulation Of MAPK Cascade Negative Regulation Of Blood Vessel Endothelial Cell Migration Reverse Cholesterol Transport Host-mediated Activation Of Viral Process Regulation Of Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Endocytosis Positive Regulation Of DNA-templated Transcription Positive Regulation Of Lipid Biosynthetic Process Intracellular Transport Regulation Of Neuronal Synaptic Plasticity Negative Regulation Of Smooth Muscle Cell Proliferation Artery Morphogenesis Negative Regulation Of Protein Secretion Negative Regulation Of Inflammatory Response Regulation Of Synapse Organization Positive Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of Lipid Biosynthetic Process Regulation Of Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Maintenance Of Location In Cell Lipid Homeostasis Fatty Acid Homeostasis Acylglycerol Homeostasis Artery Development Positive Regulation Of Dendritic Spine Development Negative Regulation Of Dendritic Spine Development Regulation Of Proteasomal Protein Catabolic Process Response To Caloric Restriction Triglyceride Homeostasis Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Lipoprotein Particle Stimulus Triglyceride-rich Lipoprotein Particle Clearance Intermediate-density Lipoprotein Particle Clearance Circulatory System Development Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Cholesterol Metabolic Process Positive Regulation Of Cholesterol Metabolic Process Negative Regulation Of Triglyceride Metabolic Process Negative Regulation Of Cholesterol Efflux Regulation Of Plasma Lipoprotein Particle Levels AMPA Glutamate Receptor Clustering NMDA Glutamate Receptor Clustering Cellular Oxidant Detoxification Positive Regulation Of Lipoprotein Transport Regulation Of Amyloid-beta Clearance Positive Regulation Of Amyloid-beta Clearance Negative Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Postsynaptic Membrane Organization Positive Regulation Of Presynaptic Membrane Organization Positive Regulation Of Amyloid-beta Formation Negative Regulation Of Amyloid-beta Formation Negative Regulation Of Dendritic Spine Maintenance Positive Regulation Of Dendritic Spine Maintenance Regulation Of Amyloid Precursor Protein Catabolic Process Positive Regulation Of Phospholipid Efflux Positive Regulation Of Neurofibrillary Tangle Assembly Negative Regulation Of Phospholipid Efflux Negative Regulation Of Lipid Transport Across Blood-brain Barrier Positive Regulation Of Lipid Transport Across Blood-brain Barrier Cellular Response To Amyloid-beta Regulation Of Cellular Response To Very-low-density Lipoprotein Particle Stimulus Regulation Of Amyloid Fibril Formation Negative Regulation Of Amyloid Fibril Formation Positive Regulation Of Amyloid Fibril Formation Regulation Of Behavioral Fear Response
Pathways		Metabolism of Angiotensinogen to Angiotensins Attachment and Entry Potential therapeutics for SARS Attachment and Entry Attachment and Entry Induction of Cell-Cell Fusion	Nuclear signaling by ERBB4 Scavenging by Class A Receptors Scavenging by Class A Receptors Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors Post-translational protein phosphorylation Chylomicron assembly Chylomicron remodeling Chylomicron clearance Chylomicron clearance HDL remodeling NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux Retinoid metabolism and transport Retinoid metabolism and transport Amyloid fiber formation
Drugs		Chloroquine Hydroxychloroquine SPP1148 Bromhexine N-(2-Aminoethyl)-1-aziridineethanamine	Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases			Alzheimer's disease (AD) Hyperlipoproteinemia, type III; Dysbetalipoproteinemia Lipoprotein glomerulopathy
GWAS			Abdominal aortic aneurysm ( 32981348) Adult body size ( 32376654) Advanced age-related macular degeneration ( 26691988) Age-related cognitive decline (memory) (slope of z-scores) ( 30954325) Age-related macular degeneration ( 23326517 23455636) Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) ( 32678081) Alanine aminotransferase levels ( 33547301) Alzheimer disease and age of onset ( 26830138) Alzheimer's disease ( 17975299 17998437 18823527 19125160 19734902 19734903 20061627 20460622 21627779 22245343 22832961 24755620 24770881 30636644 31473137 33074286) Alzheimer's disease (age of onset) ( 22005931) Alzheimer's disease (late onset) ( 17474819 20885792 23565137 26339675 28714976 30617256) Alzheimer's disease (onset at age over 80) ( 30979435) Alzheimer's disease (onset between ages 58 and 79) ( 30979435) Alzheimer's disease biomarkers ( 21123754 23419831 23562540) Alzheimer's disease in hypertension ( 31055733) Alzheimer's disease in hypertension-negative individuals ( 31055733) Alzheimer's disease or family history of Alzheimer's disease ( 30617256 33589840) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Alzheimer's disease progression score ( 29860282) Alzheimer’s disease (clinical subgroup AD+) ( 31473137) Alzheimer’s disease (clinical subgroup AD++) ( 31473137) Alzheimer’s disease (clinical subgroup AD+++) ( 31473137) Alzheimer’s disease and/or vascular dementia (clinical subgroup VaD+) ( 31473137) Apolipoprotein A1 levels ( 32203549) Apolipoprotein Levels ( 23031429) Aspartate aminotransferase levels ( 33547301) Body fat percentage ( 26833246) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Brain imaging ( 20100581) C-reactive protein ( 18439548 18439552 19567438 23844046) C-reactive protein levels ( 29403010 29878111 30388399 33339817) Cardiovascular risk factors ( 20838585) Carotid intima media thickness ( 30510157) Carotid intima media thickness (maximum) ( 31801372) Carotid intima media thickness (mean) ( 31801372) Cerebral amyloid angiopathy in APOEe4 carrier Alzheimer’s disease ( 34020725) Cerebral amyloid deposition (PET imaging) ( 26252872 30361487) Cerebral amyloid deposition positivity (PET imaging) ( 26252872) Cerebral microbleeds ( 32913026) Cerebral microbleeds (lobar) ( 32913026) Cerebrospinal AB1-42 levels in Alzheimer's disease dementia ( 25027320 29274321) Cerebrospinal AB1-42 levels in mild cognitive impairment ( 29274321) Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Cerebrospinal fluid AB1-42 levels ( 28247064 28641921 29274321 30319691) Cerebrospinal fluid p-tau levels ( 29274321) Cerebrospinal fluid p-tau levels in mild cognitive impairment ( 29274321) Cerebrospinal fluid p-Tau181p:AB1-42 ratio ( 30319691) Cerebrospinal fluid t-tau levels ( 28641921 29274321) Cerebrospinal fluid t-tau levels in mild cognitive impairment ( 29274321) Cerebrospinal fluid t-tau:AB1-42 ratio ( 28641921 30319691) Cerebrospinal P-tau181p levels ( 28247064) Cerebrospinal T-tau levels ( 28247064) Cholesterol, total ( 19060911 20686565 24097068 25961943 28270201) Cingulate cortical amyloid beta load ( 26421299) Cognitive decline ( 22054870) Cognitive decline (age-related) ( 24468470 28078323) Cognitive impairment test score ( 30319691) Coronary artery disease ( 26343387 29212778 32469254) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Dementia with Lewy bodies ( 29263008 31065058) Family history of Alzheimer's disease ( 30617256) Fasting triglyceride levels ( 32603185) Fish- and plant-related diet ( 32066663) Free cholesterol levels in large LDL ( 29084231) Fruit consumption ( 32066663) Gut microbiota (functional units) ( 27694959) HDL cholesterol ( 19060911 20686565 21909109 24097068 25961943 28270201 30275531) HDL cholesterol levels ( 26690388 28334899 32203549) HDL cholesterol levels in HIV infection ( 33109212) High density lipoprotein cholesterol levels ( 29403010 33339817) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) High-sensitivity C-reactive protein levels in HIV infection ( 33095540) Hippocampal atrophy ( 22745009) Hippocampal volume ( 29274321) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Ideal cardiovascular health (clinical) ( 27179730) Immature fraction of reticulocytes ( 27863252) Lamb consumption ( 32066663) Late-onset Alzheimer's disease ( 29360470) LDL cholesterol ( 18193043 18193044 18802019 19060906 19060911 20686565 20864672 23067351 23726366 24097068 24507774 25961943 26160806) LDL cholesterol levels ( 17463246 26763881 28334899 28371326 31087446 32759990) LDL cholesterol levels in HIV infection ( 33109212) LDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Lewy body disease ( 25188341) Lipid metabolism phenotypes ( 22286219) Lipid or lipoprotein levels ( 23696881) Lipid traits ( 24023260 30576415) Lipoprotein (a) levels ( 28512139 33730874) Lipoprotein phospholipase A2 activity in cardiovascular disease ( 28753643) Lipoprotein(a) levels adjusted for apolipoprotein(a) isoforms ( 28512139) Lipoprotein-associated phospholipase A2 activity and mass ( 23118302) Lipoprotein-associated phospholipase A2 activity change in response to darapladib treatment in cardiovascular disease ( 28753643) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (alkaline phosphatase) ( 33972514) Liver fat content (MRI proton density fat fraction measure) ( 32247823) Lobar intracerebral hemorrhage ( 31430377) Logical memory (delayed recall) ( 29274321) Logical memory (immediate recall) ( 29274321) Longevity ( 21418511 31484785) Longevity (100 years and older) ( 33948810) Longevity (85 years and older) ( 24688116) Longevity (90 years and older) ( 24688116) Longevity (age >90th survival percentile) ( 31413261) Longevity (age >99th survival percentile) ( 31413261) Low density lipoprotein cholesterol levels ( 28548082 29403010 30718733 33339817) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Meat-related diet ( 32066663) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (antithrombotic agents) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401) Medication use (salicylic acid and derivatives) ( 31015401) Mental health study participation (completed survey) ( 31263887) Metabolic syndrome ( 22399527) Metabolite levels ( 22916037) Moderate to vigorous physical activity levels ( 29899525) Mortality ( 27029810) Myocardial infarction ( 33532862) Neuritic plaque ( 31497858) Neuritic plaques or cerebral amyloid angiopathy (pleiotropy) ( 29458411) Neuritic plaques or neurofibrillary tangles (pleiotropy) ( 29458411) Neurofibrillary tangles ( 31497858) Neurofibrillary tangles or cerebral amyloid angiopathy (pleiotropy) ( 29458411) Nonalcoholic fatty liver disease ( 34841290) Parental lifespan ( 29030599 30642433) Parental longevity (both parents in top 10%) ( 29227965) Parental longevity (combined parental age at death) ( 29227965) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Parental longevity (father's age at death) ( 29227965) Parental longevity (father's attained age) ( 29227965) Parental longevity (mother's age at death or mother's attained age) ( 31484785) Parental longevity (mother's age at death) ( 29227965 31484785) Parental longevity (mother's attained age) ( 29227965) Parkinson's disease (age of onset) ( 30957308) Parkinson's disease progression (cognitive) ( 33111402) Parkinson's disease progression (composite) ( 33111402) Percent liver fat ( 34128465) Plasma amyloid beta peptide concentration (ABx-40/ABx-42 ratio) ( 34002480) Plasma amyloid beta peptide concentrations (ABx-42) ( 34002480) Platelet count ( 27863252 32888494) Plateletcrit ( 32888494) Posterior cortical atrophy and Alzheimer's disease ( 26993346) Postprandial triglyceride levels ( 32603185) Psychosis and Alzheimer's disease ( 22005930) Pulse pressure ( 30224653 30578418) Quantitative traits ( 19197348) Red cell distribution width ( 27863252 28957414 32888494) Refractive error ( 32231278) Relative sugar intake ( 32393786) Response to statins (LDL cholesterol change) ( 22331829 25350695) Resting heart rate ( 27798624) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) Serum C-reactive protein concentration ( 32928877) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Serum total cholesterol levels ( 29084231 33134509) Serum type 1 collagen metabolite levels ( 33134509) Systolic blood pressure ( 30578418) Total cholesterol levels ( 26690388 28334899 28548082 29403010 30718733 31087446 32759990 33339817) Total cholesterol levels in LDL ( 29084231) Triglyceride levels ( 28334899 29403010 30718733 33339817) Triglyceride levels in HIV infection ( 33109212) Triglycerides ( 19060911 20686565 24507774 25961943 26582766) Type 2 diabetes ( 27189021 28869590 30297969) Verbal declarative memory ( 25648963) Verbal memory performance (immediate recall change) ( 28800603) Verbal memory performance (residualized delayed recall level) ( 28800603) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659) Vigorous physical activity ( 29899525) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White matter hyperintensities ( 32358547) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549)
Interacting Genes		48 interacting genes: AGT AGTR1 AGTR2 APOE BTN3A1 BTN3A2 BTN3A3 CALM1 CAMP DEFA1 DEFA5 DLEU2 ELANE GHRL GRM2 H2AC4 HRH1 HSPA1A KDM1A LTF LYZ MAP4K3 MAS1 MAST1 MAST2 MMP14 NHERF1 NHERF2 NTS PARD3 PDZK1 PRMT5 PTPN3 SCRIB SHANK1 SHANK2 SHANK3 SHROOM2 SKP2 SLC6A19 SNX17 SNX27 TAMALIN TMPRSS11A TMPRSS11D TMPRSS2 UBR4 USP50	61 interacting genes: A2M ACE2 AKT1 ALB ANKH APP ARFGAP1 CDC37 CNTF CSNK2A1 CTSB CYP2C18 CYP2C8 ECSIT ELAVL1 EPN2 FARSA FBXL12 FOXG1 FXYD7 GCDH HSP90AA1 HTRA1 IFIT3 IFIT5 IQSEC1 LCAT LDLR LINC02582 LONP1 LOXL4 LRP1 LRP2 LRP8 MAP2 MAPT MAST1 MID1IP1 NEFM NOS3 PCMT1 PDCD4 PLEKHA6 PLTP PRAM1 PRDX2 PRNP PSEN1 RHEB RNF32 RPL4 S100B SCARB1 SNCA SORL1 ST13 TIMM29 TREM2 TYRO3 VLDLR ZNF558
Entrez ID		59272	348
HPRD ID		02274	00135
Ensembl ID		ENSG00000130234	ENSG00000130203
Uniprot IDs		A0A7I2V4H0 Q9BYF1	A0A0S2Z3D5 P02649
PDB IDs		1R42 1R4L 2AJF 3D0G 3D0H 3D0I 3KBH 3SCI 3SCJ 3SCK 3SCL 6ACG 6ACJ 6ACK 6CS2 6LZG 6M0J 6M17 6M18 6M1D 6VW1 7A91 7A92 7A94 7A95 7A96 7A97 7A98 7BH9 7CT5 7DDO 7DDP 7DF4 7DMU 7DQA 7DRV 7DWX 7DX4 7DX5 7DX6 7DX7 7DX8 7DX9 7E7E 7EDJ 7EFP 7EFR 7EKC 7EKE 7EKF 7EKG 7EKH 7FDG 7FDH 7FDI 7FEM 7JVO 7KJ2 7KJ3 7KJ4 7KMB 7KMS 7KMZ 7KNB 7KNE 7KNH 7KNI 7L0N 7L7F 7LO4 7MJM 7MJN 7NXC 7P19 7P55 7P8I 7P8J 7PKI 7R0Z 7R10 7R11 7R12 7R1A 7RPV 7SN0 7SXX 7SXY 7SXZ 7SY0 7SY1 7SY2 7SY3 7SY4 7SY5 7SY6 7SY7 7SY8 7T9K 7T9L 7TEW 7TEX 7TEZ 7TF0 7TN0 7U0N 7UFK 7UFL 7V61 7V7Z 7V80 7V81 7V82 7V83 7V84 7V85 7V86 7V87 7V88 7V89 7V8A 7V8B 7VIB 7VX4 7VX5 7VX9 7VXA 7VXB 7VXC 7VXD 7VXF 7VXK 7VXM 7W98 7W99 7W9B 7W9C 7W9I 7WBL 7WBP 7WBQ 7WGB 7WGC 7WHH 7WK4 7WK5 7WK6 7WNM 7WPA 7WPB 7WPC 7WS8 7WS9 7WSA 7WVP 7WVQ 7XAZ 7XB0 7XB1 7XBF 7XBG 7XBH 7XCH 7XCI 7XCP 7XID 7XO7 7XO8 7XO9 7XWA 7Y1Y 7Y1Z 7Y20 7Y21 7Y75 7Y76 7Y9Z 7YA0 7YA1 7YDI 7YEG 7YHW 7YJ3 7YR2 7YR3 7YR4 7ZDQ 7ZF7 8AQS 8ASY 8B9P 8BFW 8BN1 8BYJ 8DF5 8DLJ 8DLK 8DLM 8DLN 8DLP 8DLQ 8DLU 8DLV 8DM5 8DM6 8DV1 8DV2 8E7M 8FXB 8FXC 8H06 8H5C 8HRK 8HRL 8HRN 8HRU 8I91 8I92 8I93 8I9B 8I9C 8I9D 8I9E 8I9F 8I9G 8I9H 8IF2 8IOU 8IOV 8JJE 8JWH 8JYN 8JYO 8JYP 8P2W 8P2X 8P2Y 8P2Z 8P30 8P31 8QSQ 8S9G 8SPH 8SPI 8TOQ 8TOR 8TOS 8TOT 8TOU 8UZE 8VKO 8VKP 8VQR 8WBY 8WBZ 8WDR 8WDS 8WDY 8WDZ 8WE0 8WE1 8WE4 8WGV 8WGW 8WHS 8WHU 8WHZ 8WLZ 8WM3 8WP8 8WRH 8WRL 8WRM 8WRO 8WSR 8WTD 8WTJ 8WYH 8XAL 8XLM 8XLN 8XN2 8XN3 8XN5 8XNF 8XNK 8XSF 8XSJ 8XUY 8XUZ 8XV0 8XV1 8XVM 8XXW 8XY9 8XYE 8XYG 8XYO 8Y16 8Y18 8Y6A 8YZB 8YZC 8YZD 8YZE 8Z3W 8Z4X 8Z64 8Z6A 8Z7B 8Z7P 8ZBQ 9FMM 9IU1 9IUP 9IUQ 9IUU 9JJ6	1B68 1BZ4 1EA8 1GS9 1H7I 1LE2 1LE4 1LPE 1NFN 1NFO 1OEF 1OEG 1OR2 1OR3 2KC3 2KNY 2L7B 6IWB 6NCN 6NCO 7FCR 7FCS 7UVJ 8AX8 8AX9 8CDY 8CE0 8GRX
Enriched GO Terms of Interacting Partners?		Regulation Of Biological Quality Positive Regulation Of Multicellular Organismal Process Regulation Of Multicellular Organismal Process Angiotensin Type II Receptor Activity Plasma Membrane Biological Process Involved In Interaction With Symbiont Killing By Host Of Symbiont Cells Killing Of Cells Of Another Organism Synaptic Receptor Adaptor Activity Positive Regulation Of Signaling Angiotensin-activated Signaling Pathway Blood Vessel Diameter Maintenance Regulation Of Tube Size Regulation Of Cytokine Production Signal Transduction Regulation Of System Process Defense Response To Fungus Positive Regulation Of Cell Communication Vascular Process In Circulatory System Response To Fungus Cell Killing Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Signaling Receptor Binding Nitric Oxide-cGMP-mediated Signaling Circulatory System Process Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Regulation Of Signaling Positive Regulation Of Signal Transduction Serine-type Endopeptidase Activity Antimicrobial Humoral Response Defense Response To Gram-negative Bacterium G Protein-coupled Receptor Signaling Pathway Coupled To CGMP Nucleotide Second Messenger Angiotensin-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Type 2 Metabotropic Glutamate Receptor Binding Positive Regulation Of Cytokine Production Positive Regulation Of Developmental Process Low-density Lipoprotein Particle Remodeling Localization Within Membrane Regulation Of Cell Communication Brush Border Membrane Defense Response To Gram-positive Bacterium Renin-angiotensin Regulation Of Aldosterone Production Nitric Oxide Mediated Signal Transduction Extracellular Exosome Phospholipase C-activating Angiotensin-activated Signaling Pathway Regulation Of Synaptic Plasticity Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Specific Granule Lumen Type 3 Metabotropic Glutamate Receptor Binding	Apolipoprotein Binding Low-density Lipoprotein Particle Receptor Activity Astrocyte Activation Low-density Lipoprotein Particle Binding Positive Regulation Of Protein Catabolic Process High-density Lipoprotein Particle Endocytosis Memory Positive Regulation Of Catabolic Process Amyloid-beta Metabolic Process Regulation Of Multicellular Organismal Process Amyloid-beta Binding High-density Lipoprotein Particle Binding Regulation Of Defense Response Import Into Cell Regulation Of Nervous System Development Regulation Of Innate Immune Response Regulation Of Protein Catabolic Process Astrocyte Activation Involved In Immune Response Very-low-density Lipoprotein Particle Receptor Activity Regulation Of Apoptotic Process Receptor-mediated Endocytosis Retinoid Metabolic Process Main Axon Apolipoprotein A-I Binding Positive Regulation Of Lysosomal Protein Catabolic Process Very-low-density Lipoprotein Particle Binding Diterpenoid Metabolic Process Regulation Of Programmed Cell Death Regulation Of Amyloid Fibril Formation Regulation Of Immune Response Negative Regulation Of Signaling Very-low-density Lipoprotein Particle Receptor Complex Neuronal Cell Body Regulation Of Vesicle-mediated Transport Negative Regulation Of Signal Transduction Regulation Of Neurogenesis Cellular Response To Amyloid-beta Terpenoid Metabolic Process Regulation Of Phospholipid Catabolic Process High-density Lipoprotein Particle Clearance Positive Regulation Of Protein Catabolic Process In The Vacuole Regulation Of Phosphorus Metabolic Process Molecular Function Activator Activity Cargo Receptor Activity Positive Regulation Of Small Molecule Metabolic Process Negative Regulation Of Protein Metabolic Process Protein-folding Chaperone Binding Isoprenoid Metabolic Process
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