ACE2 and AGTR1

Number of citations of the paper that reports this interaction (PubMedID 33713620)
72

Data Source:
BioGRID (imaging technique, fluorescent resonance energy transfer)

		ACE2	AGTR1
Description		angiotensin converting enzyme 2	angiotensin II receptor type 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen Plasma Membrane Cilium Cell Surface Membrane Apical Plasma Membrane Endocytic Vesicle Membrane Brush Border Membrane Cell Projection Membrane Raft Extracellular Exosome	Plasma Membrane Membrane
	Molecular Function	Virus Receptor Activity Endopeptidase Activity Carboxypeptidase Activity Metallocarboxypeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Peptidyl-dipeptidase Activity Zinc Ion Binding Hydrolase Activity Identical Protein Binding Metal Ion Binding Transporter Activator Activity	Angiotensin Type I Receptor Activity G Protein-coupled Receptor Activity Angiotensin Type II Receptor Activity Protein Binding Bradykinin Receptor Binding Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cytokine Production Angiotensin Maturation Angiotensin-mediated Drinking Behavior Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Proteolysis Tryptophan Transport Viral Life Cycle Receptor-mediated Endocytosis Of Virus By Host Cell Viral Translation Regulation Of Vasoconstriction Regulation Of Cell Population Proliferation Ceramide Biosynthetic Process Symbiont Entry Into Host Cell Receptor-mediated Virion Attachment To Host Cell Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Inflammatory Response Positive Regulation Of Amino Acid Transport Maternal Process Involved In Female Pregnancy Positive Regulation Of Cardiac Muscle Contraction Membrane Fusion Negative Regulation Of ERK1 And ERK2 Cascade Blood Vessel Diameter Maintenance Entry Receptor-mediated Virion Attachment To Host Cell Positive Regulation Of Gap Junction Assembly Regulation Of Cardiac Conduction Positive Regulation Of L-proline Import Across Plasma Membrane Positive Regulation Of Reactive Oxygen Species Metabolic Process	Regulation Of Cell Growth Kidney Development Renin-angiotensin Regulation Of Aldosterone Production Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Rho Protein Signal Transduction Positive Regulation Of Macrophage Derived Foam Cell Differentiation Regulation Of Vasoconstriction Calcium-mediated Signaling Low-density Lipoprotein Particle Remodeling Regulation Of Renal Sodium Excretion Angiotensin-activated Signaling Pathway Regulation Of Cell Population Proliferation Symbiont Entry Into Host Cell Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Cell Chemotaxis Phospholipase C-activating Angiotensin-activated Signaling Pathway Positive Regulation Of Cholesterol Metabolic Process Blood Vessel Diameter Maintenance Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Metabolism of Angiotensinogen to Angiotensins Attachment and Entry Potential therapeutics for SARS Attachment and Entry Attachment and Entry Induction of Cell-Cell Fusion	Peptide ligand-binding receptors G alpha (q) signalling events Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs		Chloroquine Hydroxychloroquine SPP1148 Bromhexine N-(2-Aminoethyl)-1-aziridineethanamine	Valsartan Olmesartan Losartan Candesartan cilexetil Eprosartan Telmisartan Irbesartan Forasartan Saprisartan Tasosartan CYT006-AngQb Azilsartan medoxomil Fimasartan Angiotensin II Candesartan
Diseases			Renal tubular dysgenesis
GWAS			Birth weight ( 31043758) Chin dimples ( 27182965) Height ( 31562340) Lead levels in blood ( 25820613) Monobrow ( 27182965) Type 2 diabetes ( 31049640)
Interacting Genes		48 interacting genes: AGT AGTR1 AGTR2 APOE BTN3A1 BTN3A2 BTN3A3 CALM1 CAMP DEFA1 DEFA5 DLEU2 ELANE GHRL GRM2 H2AC4 HRH1 HSPA1A KDM1A LTF LYZ MAP4K3 MAS1 MAST1 MAST2 MMP14 NHERF1 NHERF2 NTS PARD3 PDZK1 PRMT5 PTPN3 SCRIB SHANK1 SHANK2 SHANK3 SHROOM2 SKP2 SLC6A19 SNX17 SNX27 TAMALIN TMPRSS11A TMPRSS11D TMPRSS2 UBR4 USP50	77 interacting genes: ABI3 ACE2 ADD3 AGT AGTRAP AP2M1 ARFGAP1 ARHGDIG ARRB1 ARRB2 ATP13A1 ATP1B1 BAALC BASP1 BDKRB2 BNIP3 BRD8 CBR1 CCDC25 CD37 CERS6 CUEDC2 DBNDD2 DNAJC14 DNAJC8 EGFR FAM13B FBXW11 FNBP1 GHITM GNA12 GOT1 GPAA1 GPRASP1 GRK2 GRK3 GRK5 HDGFL2 HHATL HRAS JAK1 JAK2 JKAMP KIAA0930 LCNL1 LLGL1 LZTS1 NACAD NDRG2 NOS3 NPTN NUP88 OAZ1 PCMT1 PDE6H PLCG1 PLCH2 PNMA1 PPP1R3F PSMD10 PTGFR RAB5A RAF1 RBSN RTN3 SAE1 SCG5 SELENOF SERINC3 SLC16A1 SPG21 THOP1 TMEM161A TMEM80 UBR4 UGT8 YWHAQ
Entrez ID		59272	185
HPRD ID		02274	00107
Ensembl ID		ENSG00000130234	ENSG00000144891
Uniprot IDs		A0A7I2V4H0 Q9BYF1	A0A0A0MSE3 D3DNG8 P30556 Q53YY0 Q6NUP5
PDB IDs		1R42 1R4L 2AJF 3D0G 3D0H 3D0I 3KBH 3SCI 3SCJ 3SCK 3SCL 6ACG 6ACJ 6ACK 6CS2 6LZG 6M0J 6M17 6M18 6M1D 6VW1 7A91 7A92 7A94 7A95 7A96 7A97 7A98 7BH9 7CT5 7DDO 7DDP 7DF4 7DMU 7DQA 7DRV 7DWX 7DX4 7DX5 7DX6 7DX7 7DX8 7DX9 7E7E 7EDJ 7EFP 7EFR 7EKC 7EKE 7EKF 7EKG 7EKH 7FDG 7FDH 7FDI 7FEM 7JVO 7KJ2 7KJ3 7KJ4 7KMB 7KMS 7KMZ 7KNB 7KNE 7KNH 7KNI 7L0N 7L7F 7LO4 7MJM 7MJN 7NXC 7P19 7P55 7P8I 7P8J 7PKI 7R0Z 7R10 7R11 7R12 7R1A 7RPV 7SN0 7SXX 7SXY 7SXZ 7SY0 7SY1 7SY2 7SY3 7SY4 7SY5 7SY6 7SY7 7SY8 7T9K 7T9L 7TEW 7TEX 7TEZ 7TF0 7TN0 7U0N 7UFK 7UFL 7V61 7V7Z 7V80 7V81 7V82 7V83 7V84 7V85 7V86 7V87 7V88 7V89 7V8A 7V8B 7VIB 7VX4 7VX5 7VX9 7VXA 7VXB 7VXC 7VXD 7VXF 7VXK 7VXM 7W98 7W99 7W9B 7W9C 7W9I 7WBL 7WBP 7WBQ 7WGB 7WGC 7WHH 7WK4 7WK5 7WK6 7WNM 7WPA 7WPB 7WPC 7WS8 7WS9 7WSA 7WVP 7WVQ 7XAZ 7XB0 7XB1 7XBF 7XBG 7XBH 7XCH 7XCI 7XCP 7XID 7XO7 7XO8 7XO9 7XWA 7Y1Y 7Y1Z 7Y20 7Y21 7Y75 7Y76 7Y9Z 7YA0 7YA1 7YDI 7YEG 7YHW 7YJ3 7YR2 7YR3 7YR4 7ZDQ 7ZF7 8AQS 8ASY 8B9P 8BFW 8BN1 8BYJ 8DF5 8DLJ 8DLK 8DLM 8DLN 8DLP 8DLQ 8DLU 8DLV 8DM5 8DM6 8DV1 8DV2 8E7M 8FXB 8FXC 8H06 8H5C 8HRK 8HRL 8HRN 8HRU 8I91 8I92 8I93 8I9B 8I9C 8I9D 8I9E 8I9F 8I9G 8I9H 8IF2 8IOU 8IOV 8JJE 8JWH 8JYN 8JYO 8JYP 8P2W 8P2X 8P2Y 8P2Z 8P30 8P31 8QSQ 8S9G 8SPH 8SPI 8TOQ 8TOR 8TOS 8TOT 8TOU 8UZE 8VKO 8VKP 8VQR 8WBY 8WBZ 8WDR 8WDS 8WDY 8WDZ 8WE0 8WE1 8WE4 8WGV 8WGW 8WHS 8WHU 8WHZ 8WLZ 8WM3 8WP8 8WRH 8WRL 8WRM 8WRO 8WSR 8WTD 8WTJ 8WYH 8XAL 8XLM 8XLN 8XN2 8XN3 8XN5 8XNF 8XNK 8XSF 8XSJ 8XUY 8XUZ 8XV0 8XV1 8XVM 8XXW 8XY9 8XYE 8XYG 8XYO 8Y16 8Y18 8Y6A 8YZB 8YZC 8YZD 8YZE 8Z3W 8Z4X 8Z64 8Z6A 8Z7B 8Z7P 8ZBQ 9FMM 9IU1 9IUP 9IUQ 9IUU 9JJ6	4YAY 4ZUD 6DO1 6OS0 6OS1 6OS2
Enriched GO Terms of Interacting Partners?		Regulation Of Biological Quality Positive Regulation Of Multicellular Organismal Process Regulation Of Multicellular Organismal Process Angiotensin Type II Receptor Activity Plasma Membrane Biological Process Involved In Interaction With Symbiont Killing By Host Of Symbiont Cells Killing Of Cells Of Another Organism Synaptic Receptor Adaptor Activity Positive Regulation Of Signaling Angiotensin-activated Signaling Pathway Blood Vessel Diameter Maintenance Regulation Of Tube Size Regulation Of Cytokine Production Signal Transduction Regulation Of System Process Defense Response To Fungus Positive Regulation Of Cell Communication Vascular Process In Circulatory System Response To Fungus Cell Killing Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Signaling Receptor Binding Nitric Oxide-cGMP-mediated Signaling Circulatory System Process Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Regulation Of Signaling Positive Regulation Of Signal Transduction Serine-type Endopeptidase Activity Antimicrobial Humoral Response Defense Response To Gram-negative Bacterium G Protein-coupled Receptor Signaling Pathway Coupled To CGMP Nucleotide Second Messenger Angiotensin-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Type 2 Metabotropic Glutamate Receptor Binding Positive Regulation Of Cytokine Production Positive Regulation Of Developmental Process Low-density Lipoprotein Particle Remodeling Localization Within Membrane Regulation Of Cell Communication Brush Border Membrane Defense Response To Gram-positive Bacterium Renin-angiotensin Regulation Of Aldosterone Production Nitric Oxide Mediated Signal Transduction Extracellular Exosome Phospholipase C-activating Angiotensin-activated Signaling Pathway Regulation Of Synaptic Plasticity Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Specific Granule Lumen Type 3 Metabotropic Glutamate Receptor Binding	Negative Adaptation Of Signaling Pathway Desensitization Of G Protein-coupled Receptor Signaling Pathway Beta-adrenergic Receptor Kinase Activity Regulation Of G Protein-coupled Receptor Signaling Pathway Receptor Internalization Type 1 Angiotensin Receptor Binding G Protein-coupled Receptor Binding G Protein-coupled Receptor Kinase Activity Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Receptor-mediated Endocytosis Regulation Of Cell Communication Regulation Of Signaling Angiotensin Receptor Binding Endocytic Vesicle Membrane Membrane Type II Interferon-mediated Signaling Pathway Regulation Of Apoptotic Process Regulation Of Apoptotic Signaling Pathway Regulation Of Programmed Cell Death Regulation Of Signal Transduction Intracellular Signaling Cassette Regulation Of Biological Quality Regulation Of Muscle System Process Regulation Of Protein Modification Process Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Blood Circulation Postsynaptic Density Negative Regulation Of Signal Transduction Establishment Of Protein Localization Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Endocytosis Regulation Of MAPK Cascade Regulation Of Vasoconstriction Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Positive Regulation Of Receptor Internalization Regulation Of The Force Of Heart Contraction By Chemical Signal Positive Regulation Of Gap Junction Assembly Interferon-mediated Signaling Pathway Plasma Membrane Clathrin-coated Pit Protein Transport Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Protein Phosphorylation Cytoplasm ERBB Signaling Pathway Import Into Cell Negative Regulation Of Apoptotic Process Tachykinin Receptor Signaling Pathway
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