GOT1

Name	glutamic-oxaloacetic transaminase 1
Structure
Interactors	7 interactors: ABI3BP AGTR1 CCR2 EGFR PC SHANK3 TMEM120A
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Axon Terminus Extracellular Exosome
	Molecular Function	Catalytic Activity L-aspartate:2-oxoglutarate Aminotransferase Activity Phosphatidylserine Decarboxylase Activity Protein Binding Transaminase Activity Transferase Activity Pyridoxal Phosphate Binding Carboxylic Acid Binding L-cysteine Transaminase Activity
	Biological Process	Gluconeogenesis 2-oxoglutarate Metabolic Process Oxaloacetate Metabolic Process Glycerol Biosynthetic Process Amino Acid Metabolic Process Aspartate Metabolic Process Aspartate Biosynthetic Process L-aspartate Catabolic Process Glutamate Metabolic Process Notch Signaling Pathway Amino Acid Biosynthetic Process Response To Carbohydrate L-glutamate Catabolic Process To Aspartate Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Insulin Stimulus Negative Regulation Of Collagen Biosynthetic Process Response To Immobilization Stress Malate-aspartate Shuttle Dicarboxylic Acid Metabolic Process Response To Cadmium Ion Response To Glucocorticoid Negative Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Mitochondrial Depolarization Fatty Acid Homeostasis Transdifferentiation Cellular Response To Mechanical Stimulus L-glutamate Biosynthetic Process Response To Transition Metal Nanoparticle
Pathways	Methionine salvage pathway Aspartate and asparagine metabolism Malate-aspartate shuttle
Drugs	Pyridoxal phosphate Aspartic acid Glutamic acid Cysteine Adapalene Maleic acid Copper
GWAS	Aspartate aminotransferase levels ( 21900944 30718733 ) Crohn's disease ( 22412388 ) Hypothyroidism ( 27182965 ) Liver enzyme levels (aspartate transaminase) ( 24124411 ) Mean corpuscular volume ( 29403010 ) Thyroid stimulating hormone levels ( 32769997 )
Entrez ID	2805
HPRD ID	00687
Ensembl ID	ENSG00000120053
Uniprot IDs	A0A140VK69 P17174
PDB IDs	3II0 3WZF 6DNA 6DNB 6DND 6LIG
GO Terms Enriched among Interactors ?	Positive Regulation Of Glutamate Receptor Signaling Pathway Regulation Of Glutamate Receptor Signaling Pathway Biological Process Involved In Interaction With Host Positive Regulation Of Synaptic Transmission, Glutamatergic Intracellular Signaling Cassette Angiotensin Type I Receptor Activity Multivesicular Body, Internal Vesicle Lumen Pyruvate Carboxylase Activity Regulation Of Synaptic Transmission, Glutamatergic Negative Regulation Of Eosinophil Degranulation Positive Regulation Of Astrocyte Chemotaxis T-helper 17 Cell Chemotaxis Chemokine (C-C Motif) Ligand 12 Binding Chemokine (C-C Motif) Ligand 2 Binding Bradykinin Receptor Binding Shc-EGFR Complex Viral RNA Genome Packaging Guanylate Kinase-associated Protein Clustering Positive Regulation Of Immune Complex Clearance By Monocytes And Macrophages Positive Regulation Of Thymocyte Migration Positive Regulation Of CD8-positive, Alpha-beta T Cell Extravasation Chemokine (C-C Motif) Ligand 7 Binding Positive Regulation Of Hematopoietic Stem Cell Migration Regulation Of Astrocyte Chemotaxis Symbiont Entry Into Host Cell Phospholipase C-activating Angiotensin-activated Signaling Pathway Renin-angiotensin Regulation Of Aldosterone Production Positive Regulation Of Protein Kinase C Signaling Epidermal Growth Factor Receptor Activity Positive Regulation Of Synapse Structural Plasticity Striatal Medium Spiny Neuron Differentiation Regulation Of Thymocyte Migration Regulation Of Immune Complex Clearance By Monocytes And Macrophages Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Angiotensin Type II Receptor Activity Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Regulation Of Cell Differentiation System Process Positive Regulation Of Inflammatory Response Regulation Of Protein Kinase C Signaling Epidermal Growth Factor Binding Biotin Binding Coenzyme A Binding Negative Regulation Of Cell Volume AMPA Glutamate Receptor Clustering Synaptic Receptor Adaptor Activity NMDA Glutamate Receptor Clustering Positive Regulation Of Synaptic Transmission CCR2 Chemokine Receptor Binding