GOT1 and AGTR1

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		GOT1	AGTR1
Description		glutamic-oxaloacetic transaminase 1	angiotensin II receptor type 1
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Axon Terminus Extracellular Exosome	Plasma Membrane Membrane
	Molecular Function	Catalytic Activity L-aspartate:2-oxoglutarate Aminotransferase Activity Phosphatidylserine Decarboxylase Activity Protein Binding Transaminase Activity Transferase Activity Pyridoxal Phosphate Binding Carboxylic Acid Binding L-cysteine Transaminase Activity	Angiotensin Type I Receptor Activity G Protein-coupled Receptor Activity Angiotensin Type II Receptor Activity Protein Binding Bradykinin Receptor Binding Protein Heterodimerization Activity
	Biological Process	Gluconeogenesis 2-oxoglutarate Metabolic Process Oxaloacetate Metabolic Process Glycerol Biosynthetic Process Amino Acid Metabolic Process Aspartate Metabolic Process Aspartate Biosynthetic Process L-aspartate Catabolic Process Glutamate Metabolic Process Notch Signaling Pathway Amino Acid Biosynthetic Process Response To Carbohydrate L-glutamate Catabolic Process To Aspartate Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Insulin Stimulus Negative Regulation Of Collagen Biosynthetic Process Response To Immobilization Stress Malate-aspartate Shuttle Dicarboxylic Acid Metabolic Process Response To Cadmium Ion Response To Glucocorticoid Negative Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Mitochondrial Depolarization Fatty Acid Homeostasis Transdifferentiation Cellular Response To Mechanical Stimulus L-glutamate Biosynthetic Process Response To Transition Metal Nanoparticle	Regulation Of Cell Growth Kidney Development Renin-angiotensin Regulation Of Aldosterone Production Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Rho Protein Signal Transduction Positive Regulation Of Macrophage Derived Foam Cell Differentiation Regulation Of Vasoconstriction Calcium-mediated Signaling Low-density Lipoprotein Particle Remodeling Regulation Of Renal Sodium Excretion Angiotensin-activated Signaling Pathway Regulation Of Cell Population Proliferation Symbiont Entry Into Host Cell Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Cell Chemotaxis Phospholipase C-activating Angiotensin-activated Signaling Pathway Positive Regulation Of Cholesterol Metabolic Process Blood Vessel Diameter Maintenance Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Methionine salvage pathway Aspartate and asparagine metabolism Malate-aspartate shuttle	Peptide ligand-binding receptors G alpha (q) signalling events Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs		Pyridoxal phosphate Aspartic acid Glutamic acid Cysteine Adapalene Maleic acid Copper	Valsartan Olmesartan Losartan Candesartan cilexetil Eprosartan Telmisartan Irbesartan Forasartan Saprisartan Tasosartan CYT006-AngQb Azilsartan medoxomil Fimasartan Angiotensin II Candesartan
Diseases			Renal tubular dysgenesis
GWAS		Aspartate aminotransferase levels ( 21900944 30718733) Crohn's disease ( 22412388) Hypothyroidism ( 27182965) Liver enzyme levels (aspartate transaminase) ( 24124411) Mean corpuscular volume ( 29403010) Thyroid stimulating hormone levels ( 32769997)	Birth weight ( 31043758) Chin dimples ( 27182965) Height ( 31562340) Lead levels in blood ( 25820613) Monobrow ( 27182965) Type 2 diabetes ( 31049640)
Interacting Genes		7 interacting genes: ABI3BP AGTR1 CCR2 EGFR PC SHANK3 TMEM120A	77 interacting genes: ABI3 ACE2 ADD3 AGT AGTRAP AP2M1 ARFGAP1 ARHGDIG ARRB1 ARRB2 ATP13A1 ATP1B1 BAALC BASP1 BDKRB2 BNIP3 BRD8 CBR1 CCDC25 CD37 CERS6 CUEDC2 DBNDD2 DNAJC14 DNAJC8 EGFR FAM13B FBXW11 FNBP1 GHITM GNA12 GOT1 GPAA1 GPRASP1 GRK2 GRK3 GRK5 HDGFL2 HHATL HRAS JAK1 JAK2 JKAMP KIAA0930 LCNL1 LLGL1 LZTS1 NACAD NDRG2 NOS3 NPTN NUP88 OAZ1 PCMT1 PDE6H PLCG1 PLCH2 PNMA1 PPP1R3F PSMD10 PTGFR RAB5A RAF1 RBSN RTN3 SAE1 SCG5 SELENOF SERINC3 SLC16A1 SPG21 THOP1 TMEM161A TMEM80 UBR4 UGT8 YWHAQ
Entrez ID		2805	185
HPRD ID		00687	00107
Ensembl ID		ENSG00000120053	ENSG00000144891
Uniprot IDs		A0A140VK69 P17174	A0A0A0MSE3 D3DNG8 P30556 Q53YY0 Q6NUP5
PDB IDs		3II0 3WZF 6DNA 6DNB 6DND 6LIG	4YAY 4ZUD 6DO1 6OS0 6OS1 6OS2
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Glutamate Receptor Signaling Pathway Regulation Of Glutamate Receptor Signaling Pathway Biological Process Involved In Interaction With Host Positive Regulation Of Synaptic Transmission, Glutamatergic Intracellular Signaling Cassette Angiotensin Type I Receptor Activity Multivesicular Body, Internal Vesicle Lumen Pyruvate Carboxylase Activity Regulation Of Synaptic Transmission, Glutamatergic Negative Regulation Of Eosinophil Degranulation Positive Regulation Of Astrocyte Chemotaxis T-helper 17 Cell Chemotaxis Chemokine (C-C Motif) Ligand 12 Binding Chemokine (C-C Motif) Ligand 2 Binding Bradykinin Receptor Binding Shc-EGFR Complex Viral RNA Genome Packaging Guanylate Kinase-associated Protein Clustering Positive Regulation Of Immune Complex Clearance By Monocytes And Macrophages Positive Regulation Of Thymocyte Migration Positive Regulation Of CD8-positive, Alpha-beta T Cell Extravasation Chemokine (C-C Motif) Ligand 7 Binding Positive Regulation Of Hematopoietic Stem Cell Migration Regulation Of Astrocyte Chemotaxis Symbiont Entry Into Host Cell Phospholipase C-activating Angiotensin-activated Signaling Pathway Renin-angiotensin Regulation Of Aldosterone Production Positive Regulation Of Protein Kinase C Signaling Epidermal Growth Factor Receptor Activity Positive Regulation Of Synapse Structural Plasticity Striatal Medium Spiny Neuron Differentiation Regulation Of Thymocyte Migration Regulation Of Immune Complex Clearance By Monocytes And Macrophages Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Angiotensin Type II Receptor Activity Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Regulation Of Cell Differentiation System Process Positive Regulation Of Inflammatory Response Regulation Of Protein Kinase C Signaling Epidermal Growth Factor Binding Biotin Binding Coenzyme A Binding Negative Regulation Of Cell Volume AMPA Glutamate Receptor Clustering Synaptic Receptor Adaptor Activity NMDA Glutamate Receptor Clustering Positive Regulation Of Synaptic Transmission CCR2 Chemokine Receptor Binding	Negative Adaptation Of Signaling Pathway Desensitization Of G Protein-coupled Receptor Signaling Pathway Beta-adrenergic Receptor Kinase Activity Regulation Of G Protein-coupled Receptor Signaling Pathway Receptor Internalization Type 1 Angiotensin Receptor Binding G Protein-coupled Receptor Binding G Protein-coupled Receptor Kinase Activity Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Receptor-mediated Endocytosis Regulation Of Cell Communication Regulation Of Signaling Angiotensin Receptor Binding Endocytic Vesicle Membrane Membrane Type II Interferon-mediated Signaling Pathway Regulation Of Apoptotic Process Regulation Of Apoptotic Signaling Pathway Regulation Of Programmed Cell Death Regulation Of Signal Transduction Intracellular Signaling Cassette Regulation Of Biological Quality Regulation Of Muscle System Process Regulation Of Protein Modification Process Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Blood Circulation Postsynaptic Density Negative Regulation Of Signal Transduction Establishment Of Protein Localization Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Endocytosis Regulation Of MAPK Cascade Regulation Of Vasoconstriction Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Positive Regulation Of Receptor Internalization Regulation Of The Force Of Heart Contraction By Chemical Signal Positive Regulation Of Gap Junction Assembly Interferon-mediated Signaling Pathway Plasma Membrane Clathrin-coated Pit Protein Transport Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Protein Phosphorylation Cytoplasm ERBB Signaling Pathway Import Into Cell Negative Regulation Of Apoptotic Process Tachykinin Receptor Signaling Pathway
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