SHISAL1 and PMP22

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SHISAL1	PMP22
Description		shisa like 1	peripheral myelin protein 22
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Membrane	Plasma Membrane Bicellular Tight Junction Membrane Compact Myelin Synapse
	Molecular Function	Protein Binding	Protein Binding
	Biological Process		Apoptotic Process Chemical Synaptic Transmission Nervous System Development Peripheral Nervous System Development Negative Regulation Of Cell Population Proliferation Negative Regulation Of Neuron Projection Development Cell Differentiation Bleb Assembly Myelin Assembly Myelination
Pathways			EGR2 and SOX10-mediated initiation of Schwann cell myelination
Drugs
Diseases			Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS			Allergic rhinitis ( 25085501) Amyotrophic lateral sclerosis ( 29566793) Corneal structure ( 23291589) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917) Preterm birth (maternal effect) ( 28877031) Resting heart rate ( 27798624)
Interacting Genes		28 interacting genes: ALG10 ALG10B ARLN ASPH CATSPERH CYB561A3 GIMAP5 GJB2 GPR151 GPR25 GYPC LPAR3 MFF MFSD6 PLPP6 PMP22 SCAMP5 SLC16A13 SLC35B2 SLC38A7 SLC39A7 SLC41A2 SLC52A1 SLC61A1 TMEM128 TMEM140 TMEM42 ZFPL1	64 interacting genes: APOL3 AQP6 ARL13B ASGR2 ATP6AP2 BIK C16orf54 CANX CD3G CD53 CD69 CEACAM3 CLDN18 CLDN5 CLDN6 CLEC12B CLEC14A CREB3 CREB3L1 DDX52 EBP EDA EMP1 ERGIC3 FAM209A FCGRT FFAR2 GJA8 GPR42 GPR61 GPRC5D GPX8 IFNGR2 KCNJ6 KCNN4 KLRC1 LMNA MPZ MS4A7 OPRM1 PDZK1IP1 PEX19 PGRMC2 REEP4 SAR1A SCN3B SDC4 SHISAL1 SLC10A1 SLC18A1 SLC38A1 SMIM3 SPACA1 STOM SYT2 TLCD4 TM4SF18 TM4SF19 TMEM139 TMEM14B TMEM30B TMEM31 TMX1 TSPAN12
Entrez ID		85352	5376
HPRD ID		19361	03059
Ensembl ID		ENSG00000138944	ENSG00000109099
Uniprot IDs		Q3SXP7	A0A2R8Y5L5 A8MU75 Q01453 Q6FH25
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Dolichyl Pyrophosphate Glc2Man9GlcNAc2 Alpha-1,2-glucosyltransferase Activity Bleb Assembly Transmembrane Transport Dolichol-linked Oligosaccharide Biosynthetic Process	Membrane Plasma Membrane Protein Binding Carbohydrate Binding External Side Of Plasma Membrane Natural Killer Cell Inhibitory Signaling Pathway Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Endoplasmic Reticulum Membrane Endoplasmic Reticulum
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