IRF4 and YTHDC2

Number of citations of the paper that reports this interaction (PMID 21903422)
33

Data Source:
BioGRID (affinity chromatography technology, pull down)

		IRF4	YTHDC2
Gene Name		interferon regulatory factor 4	YTH domain containing 2
Image
Gene Ontology Annotations	Cellular Component	Nuclear Nucleosome Nucleus Nucleoplasm Cytoplasm Cytosol Membrane	Nucleus Endoplasmic Reticulum
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Protein-lysine N-methyltransferase Activity Sequence-specific DNA Binding	ATP-dependent RNA Helicase Activity Protein Binding ATP Binding RNA-dependent ATPase Activity Poly(A) RNA Binding RNA Polymerase Binding
	Biological Process	Transcription, DNA-templated Peptidyl-lysine Methylation Cytokine-mediated Signaling Pathway Negative Regulation Of Toll-like Receptor Signaling Pathway T Cell Activation Defense Response To Protozoan Myeloid Dendritic Cell Differentiation Positive Regulation Of DNA Binding Histone H3 Acetylation Histone H4 Acetylation Positive Regulation Of Interleukin-10 Biosynthetic Process Positive Regulation Of Interleukin-2 Biosynthetic Process Positive Regulation Of Interleukin-13 Biosynthetic Process Positive Regulation Of Interleukin-4 Biosynthetic Process Regulation Of T-helper Cell Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway T-helper 17 Cell Lineage Commitment	RNA Processing Response To Tumor Necrosis Factor Positive Regulation By Host Of Viral Genome Replication Response To Interleukin-1
Pathways		Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system Interferon alpha/beta signaling
Drugs
Diseases
GWAS		Black vs. blond hair color ( 18483556) Black vs. red hair color ( 18483556) Celiac disease ( 20190752) Chronic lymphocytic leukemia ( 18758461) Eye color ( 20585627) Freckles ( 17952075) Freckling ( 20585627) Hair color ( 23548203 20585627) Hematology traits ( 23303382) Non-melanoma skin cancer ( 23548203) Progressive supranuclear palsy ( 21685912) Sunburns ( 23548203) Tanning ( 23548203)	F-cell distribution ( 21326311)
Protein-Protein Interactions		19 interactors: BATF BCL6 ETV7 FKBP4 HOXB13 HOXC11 IKBKAP IRAK1 MYD88 NFATC2 PRDM1 PROX1 SPI1 SPIB STAT6 TLK2 TOP1 TRAF2 YTHDC2	2 interactors: IRAK1 IRF4
Entrez ID		3662	64848
HPRD ID		03543	11690
Ensembl ID		ENSG00000137265	ENSG00000047188
Uniprot IDs		Q15306	Q9H6S0
PDB IDs		2DLL	2YU6
Enriched GO Terms of Interacting Partners?		Regulation Of Gene Expression Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Transcription, DNA-templated Regulation Of RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process RNA Metabolic Process Positive Regulation Of Cell Activation Regulation Of Nitrogen Compound Metabolic Process Cellular Metabolic Process Gene Expression Positive Regulation Of B Cell Activation Cellular Macromolecule Biosynthetic Process Regulation Of Metabolic Process Macromolecule Biosynthetic Process Regulation Of Lymphocyte Activation Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Response To Stress Regulation Of Cell Activation Negative Regulation Of Transcription From RNA Polymerase II Promoter Cell Differentiation Cellular Nitrogen Compound Metabolic Process Cell Fate Commitment Immune Response Regulation Of Immune System Process Positive Regulation Of Immune System Process Developmental Process Nitrogen Compound Metabolic Process Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Regulation Of B Cell Proliferation Negative Regulation Of Nucleic Acid-templated Transcription T-helper Cell Lineage Commitment Negative Regulation Of RNA Biosynthetic Process Immune System Process Type 2 Immune Response Epithelial Cell Development CD4-positive Or CD8-positive, Alpha-beta T Cell Lineage Commitment Negative Regulation Of Type 2 Immune Response Organ Development Lymphocyte Differentiation Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Metabolic Process Toll-like Receptor 4 Signaling Pathway Regulation Of Immune Response	Positive Regulation Of Interleukin-13 Biosynthetic Process Positive Regulation Of Interleukin-10 Biosynthetic Process Positive Regulation Of Interleukin-4 Biosynthetic Process Cytokine-mediated Signaling Pathway T-helper 17 Cell Lineage Commitment T-helper 17 Cell Differentiation Cellular Response To Cytokine Stimulus Response To Cytokine Response To Other Organism Response To Biotic Stimulus Response To Peptidoglycan Innate Immune Response T-helper Cell Lineage Commitment Positive Regulation Of Interleukin-2 Biosynthetic Process Positive Regulation Of Interleukin-13 Production CD4-positive Or CD8-positive, Alpha-beta T Cell Lineage Commitment Regulation Of Immune Response Interleukin-1-mediated Signaling Pathway Defense Response To Protozoan Positive Regulation Of Interleukin-4 Production Regulation Of Interleukin-2 Biosynthetic Process T Cell Lineage Commitment Myeloid Dendritic Cell Differentiation Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Negative Regulation Of Toll-like Receptor Signaling Pathway Response To Protozoan Myeloid Dendritic Cell Activation Positive T Cell Selection T-helper Cell Differentiation Activation Of NF-kappaB-inducing Kinase Activity Positive Regulation Of Interleukin-10 Production Regulation Of Interleukin-4 Production Positive Regulation Of Protein Metabolic Process Regulation Of T-helper Cell Differentiation Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Interleukin-2 Production Immune Response Regulation Of Immune System Process Positive Regulation Of DNA Binding Positive Regulation Of Transcription, DNA-templated Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Defense Response Lipopolysaccharide-mediated Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Dendritic Cell Differentiation CD4-positive, Alpha-beta T Cell Differentiation Regulation Of Toll-like Receptor Signaling Pathway NIK/NF-kappaB Signaling CD4-positive, Alpha-beta T Cell Activation Regulation Of NIK/NF-kappaB Signaling
Tagcloud ?		ablation abolish adhesions attenuate chip cistrome compromise decidual decidualization decidualized deep focal forkhead foxo1 hesc igfbp1 integrating intervals o1a occupancy ontology overlap pka pr prl seq shared transcriptome wnt4	atf cahl collectively cre csa cyclophilin cyclosporin downregulated facilitates hcc hcv hdac helicase hepatitis hepatocellular hepatocyte hepatocytes huh7 identical interference jun next ns5b transcribed trichostatin trimer tsa untreated
Tagcloud (Difference) ?		ablation abolish adhesions attenuate chip cistrome compromise decidual decidualization decidualized deep focal forkhead foxo1 hesc igfbp1 integrating intervals o1a occupancy ontology overlap pka pr prl seq shared transcriptome wnt4	atf cahl collectively cre csa cyclophilin cyclosporin downregulated facilitates hcc hcv hdac helicase hepatitis hepatocellular hepatocyte hepatocytes huh7 identical interference jun next ns5b transcribed trichostatin trimer tsa untreated
Tagcloud (Intersection) ?