TOX2 and UNC5CL

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TOX2	UNC5CL
Description		TOX high mobility group box family member 2	unc-5 family C-terminal like
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Cytoplasm Centrosome Cytosol Membrane
	Molecular Function	DNA Binding Transcription Coactivator Activity Protein Binding Chromatin DNA Binding	Netrin Receptor Activity Protein Binding Peptidase Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II	Signal Transduction Netrin-activated Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of JNK Cascade
Pathways
Drugs
Diseases
GWAS		Attention deficit hyperactivity disorder (inattention symptoms) ( 32595297) Colorectal cancer ( 30529582) Conduct disorder (symptom count) ( 20585324) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 27863252 32888494) Mean spheric corpuscular volume ( 32888494) Multiple sclerosis ( 31604244) Neutrophil count ( 32888494) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Red blood cell count ( 27863252 32888494) Refractive error ( 32231278) White blood cell count ( 32888494)	Alzheimer's disease or family history of Alzheimer's disease ( 33589840) Esophageal cancer ( 21642993) Gastric cancer ( 26129866) Non-cardia gastric cancer ( 26129866) Urate levels ( 31578528)
Interacting Genes		24 interacting genes: ANKS1A APP CENPP CSTF2T ENKD1 HCK HOMER3 HSF2BP HSFY1 HSFY2 LGALS4 MFHAS1 NDUFAB1 P4HA3 PHF1 RIBC1 SPG21 TCEA2 TEKT4 TEKT5 TLX3 UNC5CL YPEL3 ZNF461	7 interacting genes: KRTAP13-2 KRTAP6-1 NFKB1 PGAM1 RELA TOX2 ZMYND12
Entrez ID		84969	222643
HPRD ID		12734	09844
Ensembl ID		ENSG00000124191	ENSG00000124602
Uniprot IDs		H6UKR8 Q96NM4	H8YHX0 Q8IV45
PDB IDs
Enriched GO Terms of Interacting Partners?		Neuron Maturation Axonemal A Tubule Inner Sheath	NF-kappaB P50/p65 Complex Cellular Response To Nicotine Cellular Response To Angiotensin Actinin Binding Cellular Response To Interleukin-6 Response To Interleukin-6 Response To Muscle Stretch Response To Angiotensin Non-canonical NF-kappaB Signal Transduction Signal Transduction Involved In Regulation Of Gene Expression Negative Regulation Of Cytokine Production Involved In Inflammatory Response Response To Nicotine Transcription Coactivator Binding Tumor Necrosis Factor-mediated Signaling Pathway Canonical NF-kappaB Signal Transduction Positive Regulation Of MiRNA Metabolic Process Regulation Of Interleukin-12 Production Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of MiRNA Metabolic Process Chromatin DNA Binding Cellular Response To Tumor Necrosis Factor Response To Tumor Necrosis Factor Positive Regulation Of Hyaluronan Biosynthetic Process Secretory Granule Lumen I-kappaB/NF-kappaB Complex Phosphoglycerate Mutase Activity Bisphosphoglycerate Mutase Activity Positive Regulation Of Schwann Cell Differentiation Response To Cobalamin Negative Regulation Of Vitamin D Biosynthetic Process Toll-like Receptor TLR6:TLR2 Signaling Pathway Regulation Of Schwann Cell Differentiation NF-kappaB Complex Prolactin Signaling Pathway Intermediate Filament Mammary Gland Involution Postsynapse To Nucleus Signaling Pathway Cellular Response To Peptide Hormone Stimulus Cellular Response To Lipopolysaccharide Cellular Response To Molecule Of Bacterial Origin Response To Mechanical Stimulus Regulation Of Hyaluronan Biosynthetic Process Ankyrin Repeat Binding Cellular Response To Peptidoglycan Cellular Response To Interleukin-17 Intramolecular Phosphotransferase Activity Transcription Regulator Complex Regulation Of Vitamin Metabolic Process Defense Response To Tumor Cell Negative Regulation Of Protein Sumoylation
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