UNC5CL and KRTAP6-1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		UNC5CL	KRTAP6-1
Description		unc-5 family C-terminal like	keratin associated protein 6-1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Cytosol Membrane	Cytosol Intermediate Filament
	Molecular Function	Netrin Receptor Activity Protein Binding Peptidase Activity	Protein Binding
	Biological Process	Signal Transduction Netrin-activated Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of JNK Cascade	Keratinization
Pathways			Keratinization
Drugs
Diseases
GWAS		Alzheimer's disease or family history of Alzheimer's disease ( 33589840) Esophageal cancer ( 21642993) Gastric cancer ( 26129866) Non-cardia gastric cancer ( 26129866) Urate levels ( 31578528)
Interacting Genes		7 interacting genes: KRTAP13-2 KRTAP6-1 NFKB1 PGAM1 RELA TOX2 ZMYND12	91 interacting genes: ANAPC11 APOBEC1 ARID5A BAHD1 BHLHE40 C11orf16 CAMK2A CAMK2G CATSPER1 CCDC120 CCDC187 CCDC24 CDA CELF5 CREB5 CRYAB CYSRT1 DAZAP2 DTX2 EFEMP1 EVX2 FCHO1 GLIS2 GLIS3 GNE GPS2 GRN HELT HEY2 HHEX HOXA1 HOXC8 ITIH6 KPRP KRTAP11-1 KRTAP12-1 KRTAP12-3 KRTAP26-1 KRTAP3-1 KRTAP4-5 KRTAP6-2 KRTAP6-3 LONRF1 MAGED1 MAPK1IP1L MED25 MEIS2 MGAT5B MYOZ3 NAF1 NOTO NTAQ1 OLIG3 OSR2 OTX1 P4HA3 PATZ1 PDIA2 PITX1 PITX2 PLSCR3 PLSCR4 POU1F1 POU4F2 PRR13 PRR35 RBPMS2 RHOXF2 SMARCC1 SMN1 SMN2 SNRPB SPANXB1 TCF7L2 TEKT3 TENT5B TFAP2D TLX3 TNIP1 TOLLIP TRAPPC14 TRIP13 UNC5CL VAC14 VENTX VGLL3 VPS37C ZBTB32 ZC3H10 ZIC1 ZNF414
Entrez ID		222643	337966
HPRD ID		09844	11218
Ensembl ID		ENSG00000124602	ENSG00000184724
Uniprot IDs		H8YHX0 Q8IV45	Q3LI64
PDB IDs
Enriched GO Terms of Interacting Partners?		NF-kappaB P50/p65 Complex Cellular Response To Nicotine Cellular Response To Angiotensin Actinin Binding Cellular Response To Interleukin-6 Response To Interleukin-6 Response To Muscle Stretch Response To Angiotensin Non-canonical NF-kappaB Signal Transduction Signal Transduction Involved In Regulation Of Gene Expression Negative Regulation Of Cytokine Production Involved In Inflammatory Response Response To Nicotine Transcription Coactivator Binding Tumor Necrosis Factor-mediated Signaling Pathway Canonical NF-kappaB Signal Transduction Positive Regulation Of MiRNA Metabolic Process Regulation Of Interleukin-12 Production Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of MiRNA Metabolic Process Chromatin DNA Binding Cellular Response To Tumor Necrosis Factor Response To Tumor Necrosis Factor Positive Regulation Of Hyaluronan Biosynthetic Process Secretory Granule Lumen I-kappaB/NF-kappaB Complex Phosphoglycerate Mutase Activity Bisphosphoglycerate Mutase Activity Positive Regulation Of Schwann Cell Differentiation Response To Cobalamin Negative Regulation Of Vitamin D Biosynthetic Process Toll-like Receptor TLR6:TLR2 Signaling Pathway Regulation Of Schwann Cell Differentiation NF-kappaB Complex Prolactin Signaling Pathway Intermediate Filament Mammary Gland Involution Postsynapse To Nucleus Signaling Pathway Cellular Response To Peptide Hormone Stimulus Cellular Response To Lipopolysaccharide Cellular Response To Molecule Of Bacterial Origin Response To Mechanical Stimulus Regulation Of Hyaluronan Biosynthetic Process Ankyrin Repeat Binding Cellular Response To Peptidoglycan Cellular Response To Interleukin-17 Intramolecular Phosphotransferase Activity Transcription Regulator Complex Regulation Of Vitamin Metabolic Process Defense Response To Tumor Cell Negative Regulation Of Protein Sumoylation	Sequence-specific Double-stranded DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of RNA Metabolic Process Chromatin Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Positive Regulation Of RNA Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Nucleus Protein Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Intermediate Filament Regulation Of Gene Expression DNA Binding Positive Regulation Of Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Pattern Specification Process Keratin Filament Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Metabolic Process Sequence-specific DNA Binding Identical Protein Binding Transcription Regulator Complex Myoblast Fate Commitment Negative Regulation Of Macromolecule Metabolic Process Regionalization SMN-Sm Protein Complex Positive Regulation Of Metabolic Process Negative Regulation Of Metabolic Process Anterior/posterior Pattern Specification Calcium- And Calmodulin-dependent Protein Kinase Complex Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Atrioventricular Valve Development Embryonic Morphogenesis
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