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ALG10 and KCNH2
Number of citations of the paper that reports this interaction (PMID
14525949
)
11
Data Source:
HPRD
(in vivo)
ALG10
KCNH2
Gene Name
ALG10, alpha-1,2-glucosyltransferase
potassium channel, voltage gated eag related subfamily H, member 2
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Endoplasmic Reticulum Membrane
Integral Component Of Membrane
Nuclear Envelope
Cytoplasm
Plasma Membrane
Voltage-gated Potassium Channel Complex
Cell Surface
Molecular Function
Transferase Activity, Transferring Hexosyl Groups
Phosphorelay Sensor Kinase Activity
Inward Rectifier Potassium Channel Activity
Voltage-gated Potassium Channel Activity
Delayed Rectifier Potassium Channel Activity
Protein Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Protein Homodimerization Activity
Scaffold Protein Binding
Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization
Biological Process
Dolichol-linked Oligosaccharide Biosynthetic Process
Protein N-linked Glycosylation Via Asparagine
Post-translational Protein Modification
Cellular Protein Metabolic Process
Phosphorelay Signal Transduction System
Regulation Of Heart Rate By Hormone
Synaptic Transmission
Signal Transduction By Phosphorylation
Cellular Response To Drug
Regulation Of Membrane Potential
Potassium Ion Homeostasis
Cardiac Muscle Contraction
Regulation Of Membrane Repolarization
Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization
Potassium Ion Export
Potassium Ion Transmembrane Transport
Ventricular Cardiac Muscle Cell Action Potential
Membrane Depolarization During Action Potential
Membrane Repolarization During Action Potential
Membrane Repolarization During Cardiac Muscle Cell Action Potential
Regulation Of Heart Rate By Cardiac Conduction
Regulation Of Potassium Ion Transmembrane Transport
Negative Regulation Of Potassium Ion Transmembrane Transport
Positive Regulation Of Potassium Ion Transmembrane Transport
Negative Regulation Of Potassium Ion Export
Pathways
Defective ALG2 causes ALG2-CDG (CDG-1i)
Diseases of glycosylation
Defective ALG3 causes ALG3-CDG (CDG-1d)
Post-translational protein modification
Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2
Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS)
Defective ALG1 causes ALG1-CDG (CDG-1k)
Defective MGAT2 causes MGAT2-CDG (CDG-2a)
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
Defective MOGS causes MOGS-CDG (CDG-2b)
Defective ALG6 causes ALG6-CDG (CDG-1c)
Defective RFT1 causes RFT1-CDG (CDG-1n)
Asparagine N-linked glycosylation
Defective ALG8 causes ALG8-CDG (CDG-1h)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Defective ALG9 causes ALG9-CDG (CDG-1l)
Defective MAN1B1 causes MRT15
Defective MPDU1 causes MPDU1-CDG (CDG-1f)
Defective ALG12 causes ALG12-CDG (CDG-1g)
Defective ALG11 causes ALG11-CDG (CDG-1p)
Diseases associated with N-glycosylation of proteins
Potassium Channels
Voltage gated Potassium channels
Drugs
Dofetilide
Amsacrine
Ibutilide
Terfenadine
Prazosin
Sotalol
Doxazosin
Cisapride
Astemizole
Verapamil
Thioridazine
Quinidine
Pimozide
Miconazole
Amiodarone
Carvedilol
Terazosin
Propafenone
Halofantrine
Dronedarone
Sertindole
Diseases
GWAS
Electrocardiographic traits (
20062061
20062063
)
QT interval (
23166209
19305408
19305409
)
Protein-Protein Interactions
2 interactors:
KCNH1
KCNH2
10 interactors:
ALG10
ALG10B
CDC73
KCNE1
KCNE2
NDUFS6
PRKACA
RHOH
YWHAE
YWHAH
Entrez ID
84920
3757
HPRD ID
10346
01069
Ensembl ID
ENSG00000055118
Uniprot IDs
Q5BKT4
Q12809
Q15BH2
PDB IDs
1BYW
1UJL
2L0W
2L1M
2L4R
2LE7
4HP9
4HQA
Enriched GO Terms of Interacting Partners
?
Peptidyl-histidine Phosphorylation
Phosphorelay Signal Transduction System
Potassium Ion Transmembrane Transport
Negative Regulation Of Potassium Ion Export
Potassium Ion Transport
Regulation Of Membrane Potential
Signal Transduction By Phosphorylation
Regulation Of Heart Rate By Hormone
Regulation Of Ion Transmembrane Transport
Synaptic Transmission
Regulation Of Ion Transport
Regulation Of Heart Rate By Chemical Signal
Monovalent Inorganic Cation Transport
Membrane Repolarization During Cardiac Muscle Cell Action Potential
Membrane Repolarization During Action Potential
Potassium Ion Export
Membrane Repolarization
Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization
Negative Regulation Of Potassium Ion Transmembrane Transport
Potassium Ion Homeostasis
Metal Ion Transport
Positive Regulation Of Potassium Ion Transmembrane Transport
Cell-cell Signaling
Cation Transmembrane Transport
Peptidyl-amino Acid Modification
Ventricular Cardiac Muscle Cell Action Potential
Myoblast Fusion
Negative Regulation Of Potassium Ion Transport
Regulation Of Membrane Repolarization
Regulation Of Heart Rate By Cardiac Conduction
Cardiac Muscle Cell Action Potential Involved In Contraction
Positive Regulation Of Potassium Ion Transport
Cation Transport
Syncytium Formation
Membrane Depolarization During Action Potential
Cardiac Muscle Cell Action Potential
Ion Transmembrane Transport
Protein Phosphorylation
Regulation Of Potassium Ion Transmembrane Transport
Regulation Of Cardiac Muscle Cell Contraction
Cardiac Conduction
Negative Regulation Of Ion Transmembrane Transport
Cardiac Muscle Contraction
Negative Regulation Of Transmembrane Transport
Cellular Response To Drug
Myotube Differentiation
Regulation Of Potassium Ion Transport
Heart Contraction
Transmembrane Transport
Ion Transport
Regulation Of Ion Transmembrane Transporter Activity
Regulation Of Transmembrane Transporter Activity
Cardiac Conduction
Membrane Repolarization During Cardiac Muscle Cell Action Potential
Membrane Repolarization During Action Potential
Membrane Repolarization
Regulation Of Heart Rate
Action Potential
Regulation Of Membrane Repolarization
Regulation Of Heart Rate By Cardiac Conduction
Regulation Of Potassium Ion Transmembrane Transporter Activity
Regulation Of Ion Transmembrane Transport
Cardiac Muscle Cell Action Potential
Regulation Of Heart Contraction
Regulation Of Potassium Ion Transmembrane Transport
Regulation Of Potassium Ion Transport
Regulation Of Ion Transport
Regulation Of Membrane Potential
Regulation Of Cardiac Muscle Contraction
Regulation Of Cation Channel Activity
Regulation Of Delayed Rectifier Potassium Channel Activity
Regulation Of Striated Muscle Contraction
Potassium Ion Export
Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization
Protein N-linked Glycosylation
Ventricular Cardiac Muscle Cell Action Potential
Regulation Of Muscle Contraction
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Intrinsic Apoptotic Signaling Pathway
Cardiac Muscle Cell Action Potential Involved In Contraction
Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Substantia Nigra Development
Positive Regulation Of Intracellular Transport
Regulation Of Cardiac Muscle Cell Contraction
Positive Regulation Of Transport
Dolichol-linked Oligosaccharide Biosynthetic Process
Neural Nucleus Development
Positive Regulation Of Mitochondrion Organization
Protein Glycosylation
Macromolecule Glycosylation
Glycosylation
Apoptotic Signaling Pathway
Glucocorticoid Catabolic Process
Positive Regulation Of Dense Core Granule Biogenesis
Regulation Of Cyclic Nucleotide-gated Ion Channel Activity
Glycoprotein Biosynthetic Process
Midbrain Development
Carbohydrate Metabolic Process
Regulation Of Intracellular Transport
Tagcloud
?
1c
currents
eag
eag1
elk
erg
erg1
governed
heag1
herg
imbalance
immuno
itim
kcnh1
kv10
kv11
kv12
nothing
phosphatases
pp1
prototypes
ptp
ptpn6
qt
shp
src40
subfamilies
superfamily
underlie
Tagcloud (Difference)
?
1c
currents
eag
eag1
elk
erg
erg1
governed
heag1
herg
imbalance
immuno
itim
kcnh1
kv10
kv11
kv12
nothing
phosphatases
pp1
prototypes
ptp
ptpn6
qt
shp
src40
subfamilies
superfamily
underlie
Tagcloud (Intersection)
?