ALG10 and KCNH1

Number of citations of the paper that reports this interaction (PMID 9722534)
6

Data Source:
HPRD (in vitro)

		ALG10	KCNH1
Gene Name		ALG10, alpha-1,2-glucosyltransferase	potassium channel, voltage gated eag related subfamily H, member 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Membrane Integral Component Of Membrane	Nuclear Inner Membrane Nucleoplasm Cytoplasm Plasma Membrane Voltage-gated Potassium Channel Complex
	Molecular Function	Transferase Activity, Transferring Hexosyl Groups	Phosphorelay Sensor Kinase Activity Delayed Rectifier Potassium Channel Activity Protein Binding Calmodulin Binding
	Biological Process	Dolichol-linked Oligosaccharide Biosynthetic Process Protein N-linked Glycosylation Via Asparagine Post-translational Protein Modification Cellular Protein Metabolic Process	Phosphorelay Signal Transduction System Potassium Ion Transport Synaptic Transmission Myoblast Fusion Signal Transduction By Phosphorylation Regulation Of Ion Transmembrane Transport Regulation Of Membrane Potential Potassium Ion Transmembrane Transport
Pathways		Defective ALG2 causes ALG2-CDG (CDG-1i) Diseases of glycosylation Defective ALG3 causes ALG3-CDG (CDG-1d) Post-translational protein modification Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective ALG1 causes ALG1-CDG (CDG-1k) Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective MOGS causes MOGS-CDG (CDG-2b) Defective ALG6 causes ALG6-CDG (CDG-1c) Defective RFT1 causes RFT1-CDG (CDG-1n) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) Defective ALG11 causes ALG11-CDG (CDG-1p) Diseases associated with N-glycosylation of proteins	Potassium Channels Voltage gated Potassium channels
Drugs
Diseases
GWAS			Circulating vasoactive peptide levels ( 23381795)
Protein-Protein Interactions		2 interactors: KCNH1 KCNH2	9 interactors: ALG10 CALM1 FASTKD5 KCNB1 KCNC1 KCNF1 KCNH5 SDCBP WDYHV1
Entrez ID		84920	3756
HPRD ID		10346	04492
Ensembl ID
Uniprot IDs		Q5BKT4	O95259
PDB IDs
Enriched GO Terms of Interacting Partners?		Peptidyl-histidine Phosphorylation Phosphorelay Signal Transduction System Potassium Ion Transmembrane Transport Negative Regulation Of Potassium Ion Export Potassium Ion Transport Regulation Of Membrane Potential Signal Transduction By Phosphorylation Regulation Of Heart Rate By Hormone Regulation Of Ion Transmembrane Transport Synaptic Transmission Regulation Of Ion Transport Regulation Of Heart Rate By Chemical Signal Monovalent Inorganic Cation Transport Membrane Repolarization During Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Potassium Ion Export Membrane Repolarization Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Negative Regulation Of Potassium Ion Transmembrane Transport Potassium Ion Homeostasis Metal Ion Transport Positive Regulation Of Potassium Ion Transmembrane Transport Cell-cell Signaling Cation Transmembrane Transport Peptidyl-amino Acid Modification Ventricular Cardiac Muscle Cell Action Potential Myoblast Fusion Negative Regulation Of Potassium Ion Transport Regulation Of Membrane Repolarization Regulation Of Heart Rate By Cardiac Conduction Cardiac Muscle Cell Action Potential Involved In Contraction Positive Regulation Of Potassium Ion Transport Cation Transport Syncytium Formation Membrane Depolarization During Action Potential Cardiac Muscle Cell Action Potential Ion Transmembrane Transport Protein Phosphorylation Regulation Of Potassium Ion Transmembrane Transport Regulation Of Cardiac Muscle Cell Contraction Cardiac Conduction Negative Regulation Of Ion Transmembrane Transport Cardiac Muscle Contraction Negative Regulation Of Transmembrane Transport Cellular Response To Drug Myotube Differentiation Regulation Of Potassium Ion Transport Heart Contraction Transmembrane Transport Ion Transport	Synaptic Transmission Regulation Of Ion Transmembrane Transport Cell-cell Signaling Potassium Ion Transmembrane Transport Potassium Ion Transport Regulation Of Ion Transport Monovalent Inorganic Cation Transport Protein Homooligomerization Energy Derivation By Oxidation Of Organic Compounds Metal Ion Transport Cation Transmembrane Transport Generation Of Precursor Metabolites And Energy Protein Oligomerization Cation Transport Ion Transmembrane Transport Energy Reserve Metabolic Process Positive Regulation Of Extracellular Vesicular Exosome Assembly Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Regulation Of High Voltage-gated Calcium Channel Activity Regulation Of Extracellular Vesicular Exosome Assembly Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Transmembrane Transport Ion Transport Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Cellular Component Assembly Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Peptidyl-histidine Phosphorylation Transport Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Detection Of Calcium Ion Substrate-dependent Cell Migration, Cell Extension Regulation Of Cell Communication By Electrical Coupling Positive Regulation Of Phosphoprotein Phosphatase Activity Protein Complex Assembly Regulation Of Cellular Localization Phosphorelay Signal Transduction System Positive Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Protein Autophosphorylation Positive Regulation Of Nitric-oxide Synthase Activity Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Glycogen Catabolic Process Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Negative Regulation Of Peptidyl-threonine Phosphorylation Signaling Regulation Of Voltage-gated Calcium Channel Activity Positive Regulation Of Protein Dephosphorylation Negative Regulation Of Cation Channel Activity Cell Communication Polysaccharide Catabolic Process
Tagcloud ?			1c currents eag eag1 elk erg erg1 governed heag1 herg imbalance immuno itim kcnh2 kv10 kv11 kv12 nothing phosphatases pp1 prototypes ptp ptpn6 qt shp src40 subfamilies superfamily underlie
Tagcloud (Difference) ?			1c currents eag eag1 elk erg erg1 governed heag1 herg imbalance immuno itim kcnh2 kv10 kv11 kv12 nothing phosphatases pp1 prototypes ptp ptpn6 qt shp src40 subfamilies superfamily underlie
Tagcloud (Intersection) ?