PHF5A and PRPF31

Number of citations of the paper that reports this interaction (PubMedID 22365833)
0

Data Source:
BioGRID (two hybrid, two hybrid)

		PHF5A	PRPF31
Description		PHD finger protein 5A	pre-mRNA processing factor 31
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex U2-type Spliceosomal Complex U2 SnRNP U12-type Spliceosomal Complex Nuclear Matrix Nuclear Speck U2-type Precatalytic Spliceosome Precatalytic Spliceosome	Nucleus Nucleoplasm Spliceosomal Complex U2-type Spliceosomal Complex U4 SnRNP U4atac SnRNP Cajal Body Nuclear Speck U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome Precatalytic Spliceosome MLL1 Complex Spliceosomal Tri-snRNP Complex Ribonucleoprotein Complex
	Molecular Function	DNA Binding RNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding	RNA Binding Protein Binding U4 SnRNA Binding U4atac SnRNA Binding Protein-macromolecule Adaptor Activity Identical Protein Binding Ribonucleoprotein Complex Binding SnRNP Binding
	Biological Process	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Positive Regulation Of DNA-templated Transcription Stem Cell Differentiation U2-type Prespliceosome Assembly	Spliceosomal Tri-snRNP Complex Assembly MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing SnoRNA Localization Ribonucleoprotein Complex Localization
Pathways		mRNA Splicing - Major Pathway	mRNA Splicing - Major Pathway
Drugs
Diseases			Retinitis pigmentosa (RP)
GWAS		Appendicular lean mass ( 33097823) Asthma ( 30929738 32296059) Asthma (childhood onset) ( 30929738) Chronotype ( 30696823) Experiencing mood swings ( 29500382) Feeling tense ( 29500382) Lamb consumption ( 32066663) Meat-related diet ( 32066663) Neuroticism ( 29255261) PR interval ( 32439900) Refractive error ( 32231278)	Change in HbA1c levels in response to metformin treatment in type 2 diabetes ( 29650774)
Interacting Genes		7 interacting genes: FOXB1 GTSE1 PRPF31 PRPF6 SUMO2 U2AF2 ZDHHC17	139 interacting genes: APOBEC3C ASB15 BICD2 C1QTNF1 CALCOCO2 CAPNS2 CARD14 CBY2 CCDC106 CCDC136 CCDC33 CCDC57 CCDC70 CCNDBP1 CDC23 CDCA7L CDR2L CEBPA CEP70 CYSRT1 DVL2 DVL3 EFEMP2 EIF3E EVI5 EXOSC8 FANCA FANCC FASTK FLACC1 FSD2 FXR1 GOLGA2 GOLGA6L9 GPRASP3 HAP1 HES7 HNRNPH2 HNRNPK HOOK2 HSF2BP JAKMIP2 KANK2 KCTD6 KHDRBS2 KHDRBS3 KIFC3 KRT15 KRT31 KRT34 KRT35 KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-1 KRTAP10-3 KRTAP10-8 KRTAP10-9 KRTAP19-5 KRTAP4-11 KRTAP6-3 LBX1 LDOC1 LHX8 LURAP1 LZTS2 MDFI MEIS3 MEOX2 MID2 MIPOL1 MKRN3 MTUS2 NCAPH2 NCKIPSD NOTCH2NLA OGT PAK5 PDE4DIP PHC2 PHF5A PICK1 PLEKHG4 PNMA1 PNMA2 PNMA3 PPIH PPP1R16A PPP2R3C PRDM14 PRICKLE1 PRPF3 PSTPIP1 RACK1 RBAK RBM25 RBM4 RBMX RBMY1A1 RBMY1F RBMY1J REL RINT1 RUNDC3A SIAH1 SLAIN1 SNRNP200 SRSF3 SSX2IP STX11 TADA2A TFIP11 TLE5 TMCC2 TP53BP2 TRIM14 TRIM23 TRIM27 TRIM41 TSGA10 UBXN11 USH1G USP15 VWC2 ZFP64 ZFP69B ZNF24 ZNF250 ZNF408 ZNF417 ZNF473 ZNF48 ZNF587 ZNF668 ZNF71 ZNF774 ZNF792 ZNF837 ZSCAN22
Entrez ID		84844	26121
HPRD ID		15126	05917
Ensembl ID		ENSG00000100410	ENSG00000105618
Uniprot IDs		Q7RTV0	Q8WWY3
PDB IDs		5IFE 5O9Z 5SYB 5Z56 5Z57 5Z58 5ZYA 6AH0 6AHD 6EN4 6FF4 6FF7 6QX9 6Y50 6Y5Q 7ABG 7ABH 7ABI 7B0I 7B91 7B92 7B9C 7DVQ 7EVN 7EVO 7OMF 7ONB 7OPI 7Q3L 7Q4O 7Q4P 7QTT 7VPX 8CH6 8H6E 8H6J 8H6K 8H6L 8HK1 8I0P 8I0R 8I0S 8I0T 8I0U 8I0V 8QO9 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8RM5 8Y7E	2OZB 3JCR 3SIU 3SIV 5O9Z 6AH0 6AHD 6QW6 6QX9 8H6E 8H6J 8H6K 8H6L 8Q7N 8QO9 8QOZ 8QP8 8QP9 8QPA 8QPB 8QPE 8QPK 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8RM5 8Y6O
Enriched GO Terms of Interacting Partners?		Spliceosomal Complex RNA Splicing, Via Transesterification Reactions Protein-RNA Complex Assembly MRNA Splicing, Via Spliceosome RNA Localization Spliceosomal Tri-snRNP Complex Assembly U4/U6 X U5 Tri-snRNP Complex Ribonucleoprotein Complex Binding Spliceosomal SnRNP Assembly Spliceosomal Complex Assembly U2-type Precatalytic Spliceosome Perforant Pathway To Dendrate Granule Cell Synapse Ribonucleoprotein Complex Localization Mammillothalamic Axonal Tract Development Cell Migration In Diencephalon Mammary Gland Lobule Development Mammillary Body Development RNA Splicing Poly-pyrimidine Tract Binding Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission U4atac SnRNP Inferior Colliculus Development Nuclear Speck MRNA Processing SnRNP Binding U4atac SnRNA Binding Axon Target Recognition Epithelial Cell Differentiation Involved In Mammary Gland Alveolus Development Basolateral Protein Secretion Commitment Complex Protein-cysteine S-myristoyltransferase Activity SnoRNA Localization U2AF Complex MRNA Metabolic Process Pre-mRNA 3'-splice Site Binding Protein-cysteine S-stearoyltransferase Activity Spliceosomal Tri-snRNP Complex Cytoplasmic Vesicle Membrane U4 SnRNA Binding Floor Plate Development Hypothalamus Cell Migration RNA Binding Protein-macromolecule Adaptor Activity Regulation Of Neurotrophin TRK Receptor Signaling Pathway U4 SnRNP Thalamus Development Clathrin Adaptor Complex AP-1 Adaptor Complex Nucleoplasm	Protein Binding Intermediate Filament Keratin Filament Identical Protein Binding Nucleus Regulation Of MRNA Splicing, Via Spliceosome Regulation Of RNA Splicing Regulation Of MRNA Processing MRNA Processing Regulation Of RNA Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Metabolic Process Spliceosomal Complex Regulation Of Nucleobase-containing Compound Metabolic Process Structural Constituent Of Skin Epidermis RNA Splicing Nucleic Acid Binding Regulation Of MRNA Metabolic Process Zinc Ion Binding Positive Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Primary Metabolic Process RNA Processing Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression MRNA Binding Negative Regulation Of Viral Transcription Cytoskeleton Intermediate Filament Organization Positive Regulation Of RNA Splicing Regulation Of RNA Biosynthetic Process Regulation Of Viral Transcription
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