MAGEL2 and VPS52

Number of citations of the paper that reports this interaction (PubMedID 28973533)
77

Data Source:
BioGRID (two hybrid)

		MAGEL2	VPS52
Description		MAGE family member L2	VPS52 subunit of GARP complex
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Endosome Early Endosome Cytosol Retromer Complex	GARP Complex Endosome Golgi Apparatus Cytosol Endosome Membrane Membrane Trans-Golgi Network Membrane Perinuclear Region Of Cytoplasm Recycling Endosome Presynapse Postsynapse EARP Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding	Protein Binding Syntaxin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Arp2/3 Complex-mediated Actin Nucleation Retrograde Transport, Endosome To Golgi Regulation Of Circadian Rhythm Negative Regulation Of DNA-templated Transcription Rhythmic Process Positive Regulation Of Actin Nucleation Protein K63-linked Ubiquitination	Protein Targeting Golgi To Vacuole Transport Lysosomal Transport Ectodermal Cell Differentiation Protein Transport Endocytic Recycling Retrograde Transport, Endosome To Golgi Embryonic Ectodermal Digestive Tract Development Vesicle-mediated Cholesterol Transport
Pathways			Retrograde transport at the Trans-Golgi-Network
Drugs
Diseases
GWAS		Menarche (age at onset) ( 25231870) Serum metabolite concentrations in chronic kidney disease ( 29545352)	Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 26426971)
Interacting Genes		6 interacting genes: FHL2 IRS4 PCGF6 RNF41 SUFU VPS52	101 interacting genes: AAMP AIRIM ARNT2 ATP6V1D BYSL C1orf216 CABP5 CACNA1A CATSPERT CCDC102B CCDC13 CCDC146 CCDC185 CCDC187 CCDC33 CCDC57 CCHCR1 CDC20B CDC5L CDK18 CEP19 CFAP206 CWF19L2 DCX DDX6 DNAJC11 DTNB EPM2AIP1 FAM110A FAM161A FAM161B FAM184A FAM50B GEM GFM2 GOLGA1 GORASP2 GPKOW HAUS1 HDAC4 HEATR1 HGS HOXB5 JAKMIP2 KANK2 KIAA1217 KIF5B KIF9 KIFC3 KLC3 KLHL42 LMO4 LNX1 MAGEL2 MAPK3 METTL13 MFAP1 MRPL1 MRPL11 NDC80 NFKBIB NOP2 NR2C2AP OTUD6A PIMREG PKN3 PPP1R18 PRKAA1 PRKAA2 RAB4A RAB4B RABEP2 RUNX1T1 SCNM1 SH2D4A SMARCE1 STX11 TAB2 TBC1D1 TBC1D22B TCEANC TCP11L1 TEAD4 THAP11 TPM3 TRAF4 TRAF6 TSSK3 TSTD2 TXLNB TXN2 USP2 VEZF1 VPS28 VPS53 WASHC3 WTAP ZC2HC1C ZMAT2 ZNF417 ZNF587
Entrez ID		54551	6293
HPRD ID		12008	09142
Ensembl ID		ENSG00000254585	ENSG00000223501
Uniprot IDs		Q9UJ55	A0A1U9X8S4 B3KMF7 B4DS44 Q4VXZ2 Q8N1B4
PDB IDs
Enriched GO Terms of Interacting Partners?		Atrial Cardiac Muscle Cell Development Embryonic Ectodermal Digestive Tract Development Interleukin-3 Receptor Binding Smoothened Signaling Pathway Involved In Spinal Cord Motor Neuron Cell Fate Specification Regulation Of Cellular Response To Drug Positive Regulation Of Cellular Response To Drug Positive Regulation Of Response To Drug Erythropoietin Receptor Binding Smoothened Signaling Pathway Involved In Ventral Spinal Cord Interneuron Specification GARP Complex EARP Complex Ectodermal Cell Differentiation GLI-SUFU Complex Transcription Corepressor Activity Vesicle-mediated Cholesterol Transport Regulation Of Response To Drug Spinal Cord Dorsal/ventral Patterning	Protein Binding Cytoskeleton Organelle Assembly Centrosome Microtubule Binding Microtubule-based Process Histone H2BS36 Kinase Activity [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Organelle Organization Organelle Disassembly Ciliary Basal Body Kinesin Complex Protein Localization To Lipid Droplet Protein Localization To Vacuole Microtubule Cytoskeleton Organization Protein Localization To Lysosome Negative Regulation Of Tubulin Deacetylation Negative Regulation Of Hepatocyte Apoptotic Process AMP-activated Protein Kinase Activity Insulin-responsive Compartment Centriole
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